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Current Approaches in Cardiac Repair: Somatic and Stem Cell Exosomes
Purpose of ReviewMyocardial infarction, which is the most important clinical sign of coronary artery disease, is one of the leading causes of global...
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Kdm6a-CNN1 axis orchestrates epigenetic control of trauma-induced spinal cord microvascular endothelial cell senescence to balance neuroinflammation for improved neurological repair
Cellular senescence assumes pivotal roles in various diseases through the secretion of proinflammatory factors. Despite extensive investigations into...
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Fance deficiency inhibits primordial germ cell proliferation associated with transcription–replication conflicts accumulate and DNA repair defects
Fanconi anemia (FA) gene mutations are critical components in the genetic etiology of premature ovarian insufficiency (POI). Fance −/− mice detected...
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Identification of a novel GR-ARID1a-P53BP1 protein complex involved in DNA damage repair and cell cycle regulation
ARID1a (BAF250), a component of human SWI/SNF chromatin remodeling complexes, is frequently mutated across numerous cancers, and its loss of function...
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Mesenchymal Stem Cell-Derived Exosomes and Their MicroRNAs in Heart Repair and Regeneration
Mesenchymal stem cells (MSCs) can be differentiated into cardiac, endothelial, and smooth muscle cells. Therefore, MSC-based therapeutic approaches...
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Expression of Programmed Death Ligand 1 [PD-L1] and Mismatch Repair Status in Squamous Cell Carcinomas of Cervix
Background and ObjectivesTo assess mismatch repair (MMR) status and programmed death-ligand 1 (PD-L1) expression in squamous cell carcinomas of the...
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Corneal injury repair and the potential involvement of ZEB1
The cornea, consisting of three cellular and two non-cellular layers, is the outermost part of the eyeball and frequently injured by external...
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Combined with the first dorsal (plantar) metatarsal artery pedicle free bilobed flap with a cell scaffold for the repair of a mid-distal adjacent finger defect: a retrospective study
PurposeAssessing the clinical effectiveness of combining with the first dorsal (plantar) metatarsal artery pedicle free bilobed flap with a cell...
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Mesenchymal Stromal Cell Exosomes in Cardiac Repair
Purpose of the ReviewMesenchymal stromal cells (MSCs) are considered an attractive option for cell-based therapy because of their immune-privileged...
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Constitutional mismatch repair deficiency mimicking Lynch syndrome is associated with hypomorphic mismatch repair gene variants
Lynch syndrome (LS) and constitutional mismatch repair deficiency (CMMRD) are distinct cancer syndromes caused, respectively, by mono- and bi-allelic...
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MiRNA-363-3p/DUSP10/JNK axis mediates chemoresistance by enhancing DNA damage repair in diffuse large B-cell lymphoma
Anthracycline-based chemotherapy resistance represents a major challenge in diffuse large B-cell lymphoma (DLBCL). MiRNA and gene expression profiles...
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Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting
Homologous recombination (HR) and nucleotide excision repair (NER) are the two most frequently disabled DNA repair pathways in cancer. HR-deficient...
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Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function
BackgroundNumerous biological interventions and small molecules are used to treat Crohn’s disease; however, the effectiveness of these treatments...
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Cellular therapies for bone repair: current insights
Mesenchymal stem cells are core to bone homeostasis and repair. They both provide the progenitor cells from which bone cells are formed and regulate...
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Osteopontin promotes infarct repair
Understanding how macrophages promote myocardial repair can help create new therapies for infarct repair. We aimed to determine what mechanisms...
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Biologic Augmentation of Isolated Meniscal Repair
Purpose of ReviewThe limited blood supply and intrinsic healing capacity of the meniscus contributes to suboptimal tissue regeneration following...
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Emerging biologic augmentation strategies for meniscal repair: a systematic review
BackgroundMeniscal repair should be the gold standard. However, the meniscus is poorly vascularized and even an excellent meniscus repair may not...
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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization
HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the...
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A Novel Method to Repair Thin Endometrium and Restore Fertility Based on Menstruation-Derived Stem Cell
Thin endometrium (TE), which mainly occurs as a result of severe damage to the endometrial basalis, is one of the prominent etiologies of menstrual...
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Phase III clinical trial of autologous CD34 + cell transplantation to accelerate fracture nonunion repair
BackgroundWe previously demonstrated that CD34 + cell transplantation in animals healed intractable fractures via osteogenesis and vasculogenesis; we...
