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The effect of selinexor on prostaglandin synthesis in virus-positive Merkel cell carcinoma cell lines
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer with high rates of metastasis and mortality. In vitro studies suggest that...
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Establishment of canine mammary gland tumor cell lines harboring PI3K/Akt activation as a therapeutic target
Canine mammary gland tumors (MGT) have a poor prognosis in intact female canines, posing a clinical challenge. This study aimed to establish novel...
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HAMLET effect on cell death and mitochondrial respiration in colorectal cancer cell lines with KRAS/BRAF mutations
PurposeTreatment of advanced colorectal cancer (CRC) depends on the correct selection of personalized strategies. HAMLET (Human Alpha-lactalbumin...
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Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines
Acute myeloid leukemia is one of the most commonly identified hematological malignancies with poor prognosis. This research was planned to identify...
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Multi-omics analyses of choroid plexus carcinoma cell lines reveal potential targetable pathways and alterations
PurposeChoroid plexus carcinomas (CPCs) are extremely rare brain tumors and carry a dismal prognosis. Treatment options are limited and there is an...
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Intrinsic Resistance to Osimertinib in EGFR Mutated NSCLC Cell Lines Induced by Alteration in Cell-Cycle Regulators
BackgroundCell-cycle regulators are mutated in approximately 40% of all cancer types and have already been linked to worse outcomes in non-small cell...
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Evaluation of chlorophyll-loaded mesoporous silica nanoparticles for photodynamic therapy on cancer cell lines
Chlorophyll (Chl) is a promising natural photosensitizer (PS) in photodynamic treatment (PDT). Mesoporous silica nanoparticles (MSNs) were chosen to...
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Altered mitochondrial function in fibroblast cell lines derived from disease carriers of spinal muscular atrophy
BackgroundSpinal muscular atrophy (SMA) is an autosomal recessive childhood-onset neuromuscular disease with a carrier frequency of ~1:50....
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The ATR inhibitor berzosertib acts as a radio- and chemosensitizer in head and neck squamous cell carcinoma cell lines
Alterations in the DNA damage response play a crucial role in radio- and chemoresistance of neoplastic cells. Activation of the Ataxia telangiectasia...
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Anticancer potential of four triterpenoids against NCI-60 human tumor cell lines
BackgroundThe burden of cancer incidences and mortality is rapidly increasing worldwide resulting in an increased demand for new therapies. Secondary...
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Monalizumab efficacy correlates with HLA-E surface expression and NK cell activity in head and neck squamous carcinoma cell lines
PurposeNKG2A, an inhibitory receptor expressed on NK cells and T cells, leads to immune evasion by binding to HLA-E expressed on cancer cells. Here,...
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Anticancer effect of zanubrutinib in HER2-positive breast cancer cell lines
Small molecule Bruton’s tyrosine kinase (BTK) inhibitors have been developed for the treatment of various haemato-oncological diseases, and ibrutinib...
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Toxicity evaluation of synthetic glucocorticoids against breast cancer cell lines MDA-MB-231, MCF-7 and human embryonic kidney HEK293
In this study, we conducted a comprehensive assessment of the cytotoxicity of three glucocorticoids, namely Hydrocortisone, Dexamethasone, and...
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The development of radioresistant oral squamous carcinoma cell lines and identification of radiotherapy-related biomarkers
BackgroundIn the treatment of oral squamous cell carcinoma (OSCC), radiation resistance remains an important obstacle to patient outcomes. Progress...
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Fisetin-induced cell death in human ovarian cancer cell lines via zbp1-mediated necroptosis
BackgroundAmong reproductive cancers, ovarian cancer leads to the highest female mortality rate. Fisetin, a natural flavonoid, exerts pharmacological...
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Anticancer properties of red beetroot hydro-alcoholic extract and its main constituent; betanin on colorectal cancer cell lines
Colorectal cancer (CRC) is the third most common type of cancer worldwide. Red beetroot ( Beta vulgaris ) contains Betanin as its major betacyanin,...
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Anticancer properties and metabolomic profiling of Shorea roxburghii extracts toward gastrointestinal cancer cell lines
BackgroundGastrointestinal cancer (GIC) ranks as the highest cause of cancer-related deaths globally. GIC patients are often diagnosed at advanced...
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Radiation modulates expression and related activities of c-Met protein in oral tongue squamous cell carcinoma cell lines
Objectivesc-Met, a receptor tyrosine kinase, is involved in the growth, invasion and metastasis of a variety of cancers. In a set of cell lines from...
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Cytotoxicity of poly-guanidine in medulloblastoma cell lines
Medulloblastoma (MB) is the most common pediatric brain tumor. The therapy frequently causes serious side effects, and new selective therapies are...
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Modelling reoxygenation effects in non-small cell lung cancer cell lines and showing epithelial-mesenchymal transition
PurposeCirculating tumour cells (CTCs) are a rare cell subpopulation regulated by the tumour microenvironment. In hypoxic conditions, CTCs are able...
