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A review on cell damage, viability, and functionality during 3D bioprinting
Three-dimensional (3D) bioprinting fabricates 3D functional tissues/organs by accurately depositing the bioink composed of the biological materials...
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PD1 ligand functionality a biomarker of response to anti PD1 treatment in patients with HNSCC
Therapies targeting the PD-1/PD-L1 pathway have transformed head and neck squamous cell carcinoma (HNSCC) treatment. However, predicting the response...
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Effect of superficial adipose tissue mitochondrial and cellular functionality induced by extracorporeal shock wave therapy (ESWT)
Due to its regenerative action, extracorporeal shock wave therapy (ESWT) is applied in treating integumentary and musculoskeletal diseases. However,...
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Central sensitization significantly deteriorates functionality and the interpretation of self-reported disease activity in primary Sjögren’s syndrome
BackgroundCentral sensitization has a major role in health-related parameters in musculoskeletal conditions. There is still a lack of understanding...
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Selective depletion of Campylobacter jejuni via T6SS dependent functionality: an approach for improving chickens gut health
The targeted depletion of potential gut pathogens is often challenging because of their intrinsic ability to thrive in harsh gut environments....
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T-cell Cholesterol Accumulation, Aging, and Atherosclerosis
Purpose of ReviewThe majority of leukocytes in advanced human atherosclerotic plaques are T-cells. T-cell subsets exert pro- or anti-atherogenic...
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Blockade of the TIGIT-CD155/CD112 axis enhances functionality of NK-92 but not cytokine-induced memory-like NK cells toward CD155-expressing acute myeloid leukemia
TIGIT is an alternative checkpoint receptor (CR) whose inhibition promotes Graft-versus-Leukemia effects of NK cells. Given the significant...
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Phase angle, muscle mass, and functionality in patients with Parkinson’s disease
ObjectiveTo evaluate the association of phase angle (PA) with clinical and nutritional aspects in patients with Parkinson’s disease (PD) treated in...
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Human placental extract suppresses mast cell activation and induces mast cell apoptosis
BackgroundHuman placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of...
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Immunophenoty** with (phospho)protein profiling and fluorescent cell barcoding for single-cell signaling analysis and biomarker discovery
The microenvironment of hematologic cancers contributes to tumor cell survival and proliferation, as well as treatment resistance. Understanding...
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Physical and autonomic functionality in women with breast cancer pre and post chemotherapy: a case control study
BackgroundBreast cancer (BC) is one of the most incident types of cancer among women in the world. Although chemotherapy is an effective way to treat...
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The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges
In recent years, the potential of stem cells (SCs) to differentiate into various types of cells, including β-cells, has led to a significant boost in...
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Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
T cell differentiation is a highly regulated, multi-step process necessary for the progressive establishment of effector functions, immunological...
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Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of develo** autism spectrum disorder
Evidence from cross-sectional human studies, and preliminary microbial-based intervention studies, have implicated the microbiota-gut-brain axis in...
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Phenotypic and functional analysis in HER2+ targeted therapy of human NK cell subpopulation according to the expression of FcεRIγ and NKG2C in breast cancer patients
Adaptive NK cells constitute an NK cell subpopulation, which expands after human cytomegalovirus (HCMV) infection. This subpopulation has stronger...
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Pilot prospective study of Frailty and Functionality in routine clinical assessment in allogeneic hematopoietic cell transplantation
A Frailty and Functionality evaluation for alloHCT was implemented using existing resources. We describe the implementation of this evaluation across...
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Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Hotspot driver mutations presented by human leukocyte antigens might be recognized by anti-tumor T cells. Based on their advantages of...
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Unraveling T cell exhaustion in the immune microenvironment of osteosarcoma via single-cell RNA transcriptome
AbstractOsteosarcoma (OS) represents a profoundly invasive malignancy of the skeletal system. T cell exhaustion (Tex) is known to facilitate...
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B cell response after SARS-CoV-2 mRNA vaccination in people living with HIV
BackgroundLimited longitudinal data are available on immune response to mRNA SARS-CoV-2 vaccination in people living with HIV (PLWHIV); therefore,...
