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Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid
BackgroundLate gadolinium enhancement (LGE) is a valuable part of cardiac magnetic resonance imaging (CMR). In particular, inversion-recovery imaging...
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Incidental scan findings in cardiac amyloid scintigraphy
When interpreting amyloid scintigraphy the nuclear cardiology physician should be aware of incidental image findings that may interfere with scan...
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Molecular mechanisms and emerging therapies in wild-type transthyretin amyloid cardiomyopathy
Wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) is an underrecognized cause of heart failure due to misfolded wild-type transthyretin...
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A case of disappearing amyloid on technetium pyrophosphate scan
Technetium-99mm pyrophosphate (Tc-PYP) scintigraphy is a highly accurate non-invasive method for the diagnosis of transthyretin (ATTR) cardiac...
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Amyloid seeding as a disease mechanism and treatment target in transthyretin cardiac amyloidosis
Transthyretin (TTR) is a tetrameric transport protein mainly synthesized by the liver and choroid plexus. ATTR amyloidosis is characterized by the...
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Cardiac Amyloidosis Diagnosis and Treatment
Cardiac amyloidosis (CA) is caused by the accumulation of amyloid fibrils in the extracellular space of the myocardium, with clinical manifestations...
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Inverse correlation between age of onset and myocardial amyloid deposition quantified by 99mTc-PYP scintigraphy in patients with wild-type transthyretin amyloid cardiomyopathy
ObjectiveWild-type transthyretin amyloidosis cardiomyopathy (ATTRwt-CM) is increasingly recognized as a contributing factor to cardiac insufficiency...
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Update on Amyloid Polyneuropathy and Treatment
Purpose of ReviewThe purpose of this review is to summarize currently available and develo** diagnostic and treatment options for hereditary...
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Amyloid deposit corresponds to technetium-99m-pyrophosphate accumulation in abdominal fat of patients with transthyretin cardiac amyloidosis
BackgroundRadionuclide imaging using bone-avid tracers plays a critical role in diagnosing transthyretin cardiac amyloidosis (ATTR-CA), but...
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Is postoperative cognitive decline after cardiac surgery associated with plasma beta amyloid 1–42 levels?
BackgroundPostoperative cognitive decline following cardiac surgery is one of the frequently reported complications affecting postoperative outcome,...
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Transthyretin derived amyloid deposits in the atrium and the aortic valve: insights from multimodality evaluations and mid-term follow up
BackgroundRecent studies have reported atrial involvement and coexistence of aortic stenosis in transthyretin (ATTR) cardiac amyloidosis (CA)....
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Attacking the Achilles heel of cardiac amyloid nuclear scintigraphy: How to reduce equivocal and false positive studies
BackgroundPlanar and single-photon emission computed tomography (SPECT) nuclear imaging techniques with bone seeking radiotracers have been...
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Valvular heart disease in patients with cardiac amyloidosis
Cardiac amyloidosis (CA) is an underdiagnosed condition caused by the deposition of misfolded proteins, namely immunoglobulin light chains and...
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Tafamidis therapy in transthyretin amyloid cardiomyopathy: a narrative review from clinical trials and real-world evidence
BackgroundAmyloidosis is a heterogeneous group of disorders caused by the extracellular deposition of insoluble misfolded proteins, leading to...
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Detection and Diagnosis of Cardiac Amyloidosis in Egypt
Cardiac amyloidosis is a life-threatening disease that occurs when amyloid proteins, most commonly immunoglobulin light chain or transthyretin,...
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Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study
BackgroundIn a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP...
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Current Therapies and Future Horizons in Cardiac Amyloidosis Treatment
Purpose of ReviewCardiac amyloidosis (CA) is a condition characterized by misfolding and extracellular deposition of proteins, leading to organ...
