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Correlation between sKL and Nrf2 plasma levels and calcium oxalate urolithiasis
ObjectiveTo investigate the relationship between plasma levels of sKL and Nrf2 and calcium oxalate calculi.
MethodsThe clinical data of 135 patients...
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Osteopontin phosphopeptide mitigates calcium oxalate stone formation in a Drosophila melanogaster model
Kidney stone disease affects nearly one in ten individuals and places a significant economic strain on global healthcare systems. Despite the high...
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Vinegar reduced renal calcium oxalate stones by regulating acetate metabolism in gut microbiota and crystal adhesion in rats
PurposeUrolithiasis is a common urologic disease. Higher consumption of vinegar was associated with a lower risk of urolithiasis. Recent studies...
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Potential role of glutathione S‑transferase M1 gene polymorphism in kidney calcium oxalate stone formation
BackgroundThe purpose of this study was to look into the effects of glutathione S-transferase M1 ( GSTM1 ) gene polymorphism on the formation of...
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Antioxidant activity and Inhibitory effects of Cydonia oblonga Miller. leaves extracts against calcium oxalate stones
Urinary stone disease is a widespread health problem in both adults and children, and its prevalence has been increasing worldwide. Various plants...
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Puerarin prevents calcium oxalate crystal-induced renal epithelial cell autophagy by activating the SIRT1-mediated signaling pathway
Calcium oxalate (CaOx) crystals can activate autophagy, causing damage to renal tubular epithelial cells (TECs). Puerarin has been shown to have...
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Calcium oxalate crystal-induced secretome derived from proximal tubular cells, not that from distal tubular cells, induces renal fibroblast activation
BackgroundKidney stone disease (KSD) is commonly accompanied with renal fibrosis, characterized by accumulation and reorganization of extracellular...
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Acute oxalate nephropathy: exploring the role of excess dietary oxalate intake
Acute oxalate nephropathy is a rare but important cause of severe acute kidney injury. We report here two cases presenting as unexplained AKI which...
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Effect of calcium content of diet on crystal formation in urine of patients with calcium oxalate stones: a randomized crossover clinical trial
BackgroundPatients with idiopathic calcium oxalate stones are advised to consume a low-oxalate diet to prevent recurrence. In this study, on patients...
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Comparison of cat and human calcium oxalate monohydrate kidney stone matrix proteomes
Despite its critical nature, the role of matrix in calcium oxalate stone formation is poorly understood. The wide diversity of proteins comprising...
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Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages
Macrophages play a role in nephrolithiasis, offering the possibility of develo** macrophage-mediated preventive therapies. To establish a system...
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STUB1 exacerbates calcium oxalate-induced kidney injury by modulating reactive oxygen species-mediated cellular autophagy via regulating CFTR ubiquitination
The formation of calcium oxalate (CaOx) crystals in the kidneys leads to renal epithelial damage and the progression of crystalline nephropathy. This...
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Calcium oxalate crystals as a cause of multiple punctate echogenic foci in benign thyroid lesions
PurposeMultiple punctate echogenic foci (MPEF) on thyroid ultrasonography reflects psammoma bodies in papillary thyroid carcinomas. However, MPEF is...
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Hormonal and molecular characterization of calcium oxalate stone formers predicting occurrence and recurrence
The purpose of the study is to investigate the role of sex hormones, androgen receptors (ARs) and miRNA/CSF-1 in occurrence and recurrence of calcium...
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Purslane-induced oxalate nephropathy: case report and literature review
BackgroundThe kidney is particularly vulnerable to toxins due to its abundant blood supply, active tubular reabsorption, and medullary interstitial...
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The altered composition of gut microbiota and biochemical features as well as dietary patterns in a southern Chinese population with recurrent renal calcium oxalate stones
The correlation among gut microbiota, biochemical features, and dietary patterns in recurrent stone formers has been inadequately investigated in the...
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Epitranscriptomic profiling of m6A RNA methylation in renal epithelial tubular cells stimulated with calcium oxalate crystals through microarray analysis
The aim of this study was to investigate the relationship of m6A RNA methylation to CaOX-induced renal tubular injury. Microarray analysis was...
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Oxalate nephropathy after pancreaticoduodenectomy: a case report
A 75-year-old male developed acute kidney injury KDIGO stage 3 a few weeks after Whipple surgery was performed for a distal cholangiocarcinoma....
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Klotho inhibits the formation of calcium oxalate stones by regulating the Keap1-Nrf2-ARE signaling pathway
PurposeOxidative damage is important in calcium oxalate (CaOx) stone development but occurs via multiple pathways. Studies have shown that klotho...
