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Eosinophils promote CD8+ T cell memory generation to potentiate anti-bacterial immunity
Memory CD8 + T cell generation is crucial for pathogen elimination and effective vaccination against infection. The cellular and molecular circuitry...
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Characteristics of premanufacture CD8+ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma
Although chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies,...
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CD8 T cell-derived perforin regulates macrophage-mediated inflammation in a murine model of gout
ObjectivesGout is characterized by hyperuricemia and recurrent inflammatory episodes caused by intra-articular crystal deposition of monosodium urate...
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Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity
CD8 + T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane...
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Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion
PurposeThe research endeavors to explore the implications of CD47 in cancer immunotherapy effectiveness. Specifically, there is a gap in...
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Evaluation of vital genes correlated with CD8 + T cell infiltration as prognostic biomarkers in stomach adenocarcinoma
BackgroundInfiltration of CD8 + T cells in the tumor microenvironment is correlated with better prognosis in various malignancies. Our study aimed to...
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Single-cell combined bioinformatics analysis: construction of immune cluster and risk prognostic model in kidney renal clear cells based on CD8+ T cell-associated genes
BackgroundKidney cancer is an immunogenic solid tumor, characterized by high tumor burden and infiltration of CD8 + T cells. Although immunotherapy...
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CD57-positive CD8 + T cells define the response to anti-programmed cell death protein-1 immunotherapy in patients with advanced non-small cell lung cancer
Immune checkpoint inhibitors have transformed the treatment landscape of non-small cell lung cancer (NSCLC). However, accurately identifying patients...
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A novel EIF3C-related CD8+ T-cell signature in predicting prognosis and immunotherapy response of nasopharyngeal carcinoma
PurposeAt present, dysfunctional CD8 + T-cells in the nasopharyngeal carcinoma (NPC) tumor immune microenvironment (TIME) have caused unsatisfactory...
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A modified immune cell infiltration score achieves ideal stratification for CD8+ T cell efficacy and immunotherapy benefit in hepatocellular carcinoma
Immunotherapy, which aims to enhance the function of T cells, has emerged as a novel therapeutic approach for hepatocellular carcinoma (HCC)....
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A unique case of a fulminant clonal CD8-positive T-cell lymphoproliferative disorder with CNS involvement
BackgroundThis is a unique case that describes the presentation, investigations, and disease trajectory of a fatal, clonal CD8-positive T-cell...
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Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however, elevated CD8 + T cell infiltration level indicates poor prognosis in...
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PGRN inhibits CD8+T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM
BackgroundTumor microenvironment actually reduces antitumor effect against the immune attack by exclusion of CD8 + T cells. Progranulin (PGRN) is a...
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SIGLEC10+ macrophages drive gastric cancer progression by suppressing CD8+ T cell function
Existing immune checkpoint inhibitors focus on activating T cells and show limited effectiveness in gastric cancer (GC). SIGLEC10 is identified as a...
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METTL14 regulates CD8+T-cell activation and immune responses to anti‐PD‐1 therapy in lung cancer
BackgroundN6-methyladenosine (m6A) modification plays an important role in lung cancer. However, methyltransferase-like 14 (METTL14), which serves as...
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Human γδ T cells induce CD8+ T cell antitumor responses via antigen-presenting effect through HSP90-MyD88-mediated activation of JNK
Human Vγ9Vδ2 T cells have attracted considerable attention as novel alternative antigen-presenting cells (APCs) with the potential to replace...
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Cholesterol induction in CD8+ T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites
BackgroundHypercholesterolemia is one of the risk factors for colorectal cancer (CRC). Cholesterol can participate in the regulation of human T cell...
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Establishment and validation of a novel CD8+ T cell-associated prognostic signature for predicting clinical outcomes and immunotherapy response in hepatocellular carcinoma via integrating single-cell RNA-seq and bulk RNA-seq
CD8+ T lymphocytes are critical in the immune response against neoplasms, yet the prognostic relevance of CD8+ T cell-associated genes in...
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Eribulin promotes proliferation of CD8+ T cells and potentiates T cell-mediated anti-tumor activity against triple-negative breast cancer cells
PurposeChemotherapeutic agents exert immunomodulatory effects on triple-negative breast cancer (TNBC) cells and immune cells. Eribulin favorably...
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High TOX expression on CD8+ T cells in pure red cell aplasia
Thymocyte selection-associated high-mobility group box protein (TOX) is an important molecule regulating the development and exhaustion of T...
