Search
Search Results
-
Advances in brain epitranscriptomics research and translational opportunities
Various chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged as crucial regulators of RNA metabolism, attracting...
-
Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors
It is essential to identify the neuronal mechanisms of Alzheimer’s Disease (AD)-associated neuropsychiatric symptoms, e.g., apathy, before improving...
-
Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis
Crosstalk between gut and brain has long been appreciated in health and disease, and the gut microbiota is a key player in communication between...
-
Ca2+-permeable AMPA receptors set the threshold for retrieval of drug memories
Frequent relapse prevents the successful treatment of substance use disorders and is triggered in part by retrieval of drug-associated memories....
-
Biology of breast cancer brain metastases and novel therapies targeting the blood brain barrier: an updated review
Brain metastasis (BM) is a critical cause of morbidity and mortality in patients with breast cancer (BC). Compared with other cancer cells, BC cells...
-
The insulin resistant brain: impact on whole-body metabolism and body fat distribution
Insulin exerts its actions not only on peripheral organs but is also transported into the brain where it performs distinct functions in various brain...
-
Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood–Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study
BackgroundEarly posttraumatic brain injury (TBI) tranexamic acid (TXA) may reduce blood–brain barrier (BBB) permeability, but it is unclear if this...
-
Systemic Therapy Approaches for Breast Cancer Brain and Leptomeningeal Metastases
Brain metastasis arising from breast cancer is associated with a poor prognosis. Various systemic chemotherapy and targeted therapies which are...
-
Whole-brain tracking of cocaine and sugar rewards processing
Natural rewards, such as food, and sex are appetitive stimuli available for animals in their natural environment. Similarly, addictive rewards such...
-
The blood–brain barrier: structure, regulation, and drug delivery
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However,...
-
Radiosynthesis and Evaluation of a C-11 Radiotracer for Transient Receptor Potential Canonical 5 in the Brain
PurposeTRPC5 belongs to the mammalian superfamily of transient receptor potential (TRP) Ca 2+ -permeable cationic channels and it has been implicated...
-
MET receptor serves as a promising target in melanoma brain metastases
The development of brain metastases hallmarks disease progression in 20–40% of melanoma patients and is a serious obstacle to therapy. Understanding...
-
Advanced brain MRI may help understand the link between migraine and multiple sclerosis
BackgroundThere is a clinical association between migraine and multiple sclerosis.
Main bodyMigraine and MS patients share similar demographics,...
-
Cerebroprotective actions of hydrogen sulfide in the epileptic brain in newborn pigs
BackgroundNeonatal epileptic seizures cause postictal dysregulation of cerebral blood flow. Hydrogen sulfide (H 2 S), a mediator with vasodilator and...
-
Advances in NK cell therapy for brain tumors
Despite advances in treatment regimens that comprise surgery, chemotherapy, and radiation, outcome of many brain tumors remains dismal, more so when...
-
Towards machine learning-based quantitative hyperspectral image guidance for brain tumor resection
BackgroundComplete resection of malignant gliomas is hampered by the difficulty in distinguishing tumor cells at the infiltration zone. Fluorescence...
-
Sniffing oxytocin: Nose to brain or nose to blood?
In recent years ample studies have reported that intranasal administration of the neuropeptide oxytocin can facilitate social motivation and...
-
Available Systemic Treatments and Emerging Therapies for Breast Cancer Brain Metastases
In 2023, breast cancer brain metastases (BCBrM) remain a major clinical challenge gaining well-deserved attention. Historically managed with local...
-
Understanding the activity of antibody–drug conjugates in primary and secondary brain tumours
Antibody–drug conjugates (ADCs), a class of targeted cancer therapeutics combining monoclonal antibodies with a cytotoxic payload via a chemical...
-
Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders
Mood and anxiety disorders typically begin in adolescence and have overlap** clinical features but marked inter-individual variation in clinical...
