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Bone marrow-derived dedifferentiated fat cells exhibit similar phenotype as bone marrow mesenchymal stem cells with high osteogenic differentiation and bone regeneration ability
BackgroundMesenchymal stem cells (MSCs) are known to have different differentiation potential depending on the tissue of origin. Dedifferentiated fat...
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MicroRNAs mediated interaction of tumor microenvironment cells with breast cancer cells during bone metastasis
Breast cancer (BC) bone metastasis is primarily osteolytic and has limited therapeutic options. Metastasized BC cells prime the secondary environment...
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Myeloid-like tumor hybrid cells in bone marrow promote progression of prostate cancer bone metastasis
BackgroundBone metastasis is the leading cause of death in patients with prostate cancer (PCa) and currently has no effective treatment. Disseminated...
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Exosomes from bone marrow mesenchymal stem cells ameliorate glucocorticoid-induced osteonecrosis of femoral head by transferring microRNA-210 into bone microvascular endothelial cells
ObjectivesBone microvascular endothelial cells (BMECs) played an important role in the pathogenesis of glucocorticoid-induced osteonecrosis of...
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Bone-metastatic lung adenocarcinoma cells bearing CD74-ROS1 fusion interact with macrophages to promote their dissemination
Approximately 40% of patients with lung adenocarcinoma (LUAD) often develop bone metastases during the course of their disease. However, scarcely any...
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The Role of Breast Cancer Cells in Bone Metastasis: Suitable Seeds for Nourishing Soil
Purpose of ReviewThe purpose of this review was to describe the characteristics of breast cancer cells prone to develo** bone metastasis and...
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Bone marrow cells contribute to seven different endothelial cell populations in the heart
Understanding the mechanisms underlying vascular regeneration in the heart is crucial for develo** novel therapeutic strategies for myocardial...
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Bone marrow stromal cells dictate lanosterol biosynthesis and ferroptosis of multiple myeloma
Ferroptosis has been demonstrated a promising way to counteract chemoresistance of multiple myeloma (MM), however, roles and mechanism of bone marrow...
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Metabolic abnormalities in the bone marrow cells of young offspring born to mothers with obesity
Background/ObjectivesIntrauterine metabolic reprogramming occurs in mothers with obesity during gestation, putting the offspring at high risk of...
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Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading...
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The density of bone marrow mononuclear cells and CD34+ cells in patients with three neurologic conditions
BackgroundThis study aimed to identify the density of mononuclear cells (MNCs) and CD34+ cells in the bone marrow of patients with three neurologic...
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Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation
A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is indispensable for the maintenance and remodeling of the...
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Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells
Myeloid-derived suppressor cells (MDSCs) are bone marrow (BM)-derived immunosuppressive cells in the tumor microenvironment, but the mechanism of...
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Sertoli Cell–Conditioned Medium Induces Differentiation of Bone Marrow–Derived Mesenchymal Stem Cells to Male Germ-Like Cells in Busulfan-Induced Azoospermic Mouse Model
Non-obstructive azoospermia is a severe form of male infertility, with limited effective treatments. Bone marrow mesenchymal stem cells (BMSCs) can...
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Lupus erythematosus cells in a bone marrow aspirate
A teenage girl presented with fevers of unknown origin and pancytopenia. Complete blood count showed anemia (hemoglobin, 9.0 g/dL), neutropenia...
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SDF-1α promotes subchondral bone sclerosis and aggravates osteoarthritis by regulating the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells
BackgroundSubchondral bone sclerosis is a major feature of osteoarthritis (OA), and bone marrow mesenchymal stem cells (BMSCs) are presumed to play...
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Exosomal miR-182 derived from bone marrow mesenchymal stem cells drives carfilzomib resistance of multiple myeloma cells by targeting SOX6
BackgroundMultiple myeloma (MM) is a common hematological malignancy. Drug resistance remains to be a major clinical challenge in MM therapy. In this...
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MiR-210 promotes bone formation in ovariectomized rats by regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells through downregulation of EPHA2
PurposeIn osteoporosis, the balance between osteogenic and adipogenic differentiation of mesenchymal stem cells (MSCs) is disrupted. The osteogenic...
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Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration
Purpose of ReviewThis review aims to summarize (i) the latest evidence on cranial neural crest cells (CNCC) contribution to craniofacial development...
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Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis
Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, and bone....
