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Bile acid profile associated with CSF and PET biomarkers in Alzheimer’s disease
BackgroundRecent studies have shown that gut microbiota can affect the development of Alzheimer’s disease (AD) through various mechanisms. Bile acids...
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Bile acids profile and redox status in healthy infants
BackgroundAt birth, human neonates are more likely to develop cholestasis and oxidative stress due to immaturity or other causes. We aimed to search...
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Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets
Bile acids, once considered mere dietary surfactants, now emerge as critical modulators of macronutrient (lipid, carbohydrate, protein) metabolism...
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Bile Acid Overload Induced by Bile Duct and Portal Vein Ligation Improves Survival after Staged Hepatectomy in Rats
ObjectiveCompared to portal vein ligation (PVL), simultaneous bile duct and portal vein ligation (BPL) can significantly enhance hypertrophy of the...
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Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy
BackgroundICP pregnant women have a unique profile of serum bile acid metabolism, thus the early and accurate identification of ICP patients is...
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Altered gut microbiota–host bile acid metabolism in IBS-D patients with liver depression and spleen deficiency pattern
BackgroundDysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical pathogenic factor of diarrhea-predominant irritable bowel...
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The changing metabolic landscape of bile acids – keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community composition and mediate...
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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk
BackgroundSepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better...
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Vertical Sleeve Gastrectomy Reduces Gut Luminal Deoxycholic Acid Concentrations in Mice
BackgroundBariatric surgery alters bile acid metabolism, which contributes to post-operative improvements in metabolic health. However, the...
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Abnormal bile acid-microbiota crosstalk promotes the development of hepatocellular carcinoma
BackgroundGut microbiota and microbe-derived metabolites are involved in the development of HCC. Bile acids (BAs) are the most important gut...
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Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids
BackgroundBiliary atresia (BA) is a rare fatal liver disease in children, and the aim of this study was to develop a method to diagnose BA early.
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l-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice
BackgroundHypercholesterolemia is closely associated with an increased risk of cardiovascular diseases. l -Arabinose exhibited hypocholesterolemia...
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Effect of Primary Versus Revisional One Anastomosis Gastric Bypass (OAGB) on Fatty Acid Profile
IntroductionOne anastomosis gastric bypass (OAGB) is one option of a revisional procedure for failed sleeve gastrectomy. Moreover, it can be used as...
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Design of the Building Research in CRC prevention (BRIDGE-CRC) trial: a 6-month, parallel group Mediterranean diet and weight loss randomized controlled lifestyle intervention targeting the bile acid-gut microbiome axis to reduce colorectal cancer risk among African American/Black adults with obesity
BackgroundAmong all racial/ethnic groups, people who identify as African American/Blacks have the second highest colorectal cancer (CRC) incidence in...
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Dietary acid load and its interaction with CETP TaqB1 polymorphisms on lipid profile among patients with Type 2 diabetes mellitus
ObjectiveGene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular...
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Bile acid, glucose, lipid profile, and liver enzyme changes in prediabetic patients 1 year after sleeve gastrectomy
BackgroundFew articles have studied individuals with prediabetes after sleeve gastrectomy. Bile acid and lipid levels remain inconsistent in...
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Improvement of vanishing bile duct syndrome with hyperlipidemia
A 75-year-old man was admitted to our hospital with acute onset of marked jaundice, elevated liver enzymes, and hyperlipidemia. He had been taking...
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The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease
Bile acids (BA) are amphipathic molecules originating from cholesterol in the liver and from microbiota-driven biotransformation in the colon. In the...
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Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation
BackgroundDrunkenness and alcoholic liver disease (ALD) are critical public health issues associated with significant morbidity and mortality due to...
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Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis
BackgroundAcute cholangitis is a severe, life-threatening infection of the biliary system that requires early diagnosis and treatment. The Tokyo...
