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Benfotiamine reduced collagen IV contents of sciatic nerve in hyperglycemic rats
BackgroundNeuropathy as a common complication of hyperglycemia in diabetic patients is probably caused by metabolic and structural changes in...
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Thiamine and diabetes: back to the future?
The first reports of a link between thiamine and diabetes date back to the 1940s. Some years later, a role for thiamine deficiency in diabetic...
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Multimodal treatment, including extracorporeal shock wave therapy, for refractory chronic tension-type headache: a case report
BackgroundFew reports have described multidisciplinary treatment, including extracorporeal shock wave therapy, for patients with refractory chronic...
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Network-based drug repurposing for schizophrenia
Despite recent progress, the challenges in drug discovery for schizophrenia persist. However, computational drug repurposing has gained popularity as...
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Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options
Purpose of the ReviewAlcohol abuse causes a wide range of disorders that affect the nervous system. These include confusion, cerebellar ataxia,...
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Drug-induced interstitial lung disease due to over-the-counter cold medicine taken daily for 25 years: a case report
IntroductionWe report a rare case of drug-induced interstitial lung disease due to over-the-counter cold medicine taken daily for 25 years to clear...
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Iron overload may be critical for liver dysfunction in anorexia nervosa, and the role of haematocrit-adjusted albumin in assessing nutritional status: a case report
BackgroundAnorexia nervosa (AN) is frequently associated with liver dysfunction, but the precise mechanism remains undefined. Since the nutritional...
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CVOT Summit Report 2023: new cardiovascular, kidney, and metabolic outcomes
The 9th Cardiovascular Outcome Trial (CVOT) Summit: Congress on Cardiovascular, Kidney, and Metabolic Outcomes was held virtually on November...
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Nuclear Tkt promotes ischemic heart failure via the cleaved Parp1/Aif axis
Transketolase (Tkt), an enzyme in pentose phosphate pathway, has been reported to regulate genome instability and cell survival in cancers. Yet, the...
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Role of Glucose Metabolism and Mitochondrial Function in Diabetic Kidney Disease
Purpose of ReviewDiabetic kidney disease (DKD) continues to be the primary cause of chronic kidney disease in the USA and around the world. The...
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Modulation of Mitochondrial Function as a Therapeutic Strategy for Neurodegenerative Diseases
Despite recent FDA approval of anti-amyloid antibodies for Alzheimer’s Disease, strategies that target early molecular mechanisms and could delay or...
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Neuroinflammation, Its Role in Alzheimer’s Disease and Therapeutic Strategies
Neuroinflammation precedes the clinical onset of various neurodegenerative diseases, including Alzheimer’s disease (AD), by years or frequently even...
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Blood thiamine pyrophosphate concentration and its correlation with the stage of diabetic retinopathy
PurposeTo assess the possible relationship between blood thiamine pyrophosphate (TPP) concentration and stage of diabetic retinopathy (DR).
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