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Mouse models of immune dysfunction: their neuroanatomical differences reflect their anxiety-behavioural phenotype
Extensive evidence supports the role of the immune system in modulating brain function and behaviour. However, past studies have revealed striking...
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Natural language processing diagnosed behavioural disturbance phenotypes in the intensive care unit: characteristics, prevalence, trajectory, treatment, and outcomes
BackgroundNatural language processing (NLP) may help evaluate the characteristics, prevalence, trajectory, treatment, and outcomes of behavioural...
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Applying psycho-behavioural phenoty** in obesity characterization
Individual differences in obesity, beyond being explained by metabolic and medical complications, are understood by alterations in eating behaviour...
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Relationship between cerebrospinal fluid/serum albumin quotient and phenotype in amyotrophic lateral sclerosis: a retrospective study on 328 patients
BackgroundWe analysed the relationship between cerebrospinal fluid (CSF)/serum albumin quotient (Q-Alb) and phenotype in a large cohort of patients...
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Motor, cognitive and behavioural profiles of C9orf72 expansion-related amyotrophic lateral sclerosis
IntroductionAmyotrophic lateral sclerosis (ALS) individuals carrying the hexanucleotide repeat expansion (HRE) in the C9orf72 gene (C9Pos) have been...
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Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis
ObjectiveHalf of ALS patients are cognitively and/or behaviourally impaired. As cognition/behaviour and cerebral glucose metabolism can be correlated...
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‘A lightbulb moment’: carers’ experiences of behavioural symptoms in motor neurone disease before and after MiNDToolkit
BackgroundTo explore carers’ experiences of behavioural symptoms in Motor Neurone Disease (MND), before and after using the MiNDToolkit, a novel...
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The phenotypic spectrum and genotype-phenotype correlations in 106 patients with variants in major autism gene CHD8
CHD8 , a major autism gene, functions in chromatin remodelling and has various roles involving several biological pathways. Therefore, unsurprisingly,...
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Language impairment in the genetic forms of behavioural variant frontotemporal dementia
BackgroundBehavioural variant fronto-temporal dementia (bvFTD) is characterised by a progressive change in personality in association with atrophy of...
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Addressing co-occurring conditions in behavioural therapy for tic disorders: a review and guideline
Co-occurring psychiatric conditions are very common in tic disorders and Tourette syndrome. These additional symptoms are often detrimental to...
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Maternal oxidative stress during pregnancy associated with emotional and behavioural problems in early childhood: implications for foetal programming
Childhood mental disorders, including emotional and behavioural problems (EBP) are increasingly prevalent. Higher maternal oxidative stress (OS)...
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Delineating the autistic phenotype in children with neurofibromatosis type 1
BackgroundExisting research has demonstrated elevated autistic behaviours in children with neurofibromatosis type 1 (NF1), but the autistic phenotype...
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The influence of culture and cognitive reserve on the clinical presentation of behavioural-variant frontotemporal dementia
Characterisation of the clinical profile of behavioural-variant frontotemporal dementia (bvFTD) has predominantly been based on Western samples. Some...
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Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses
Clinical epidemiological studies have found high co-occurrence between suicide attempts (SA) and opioid use disorder (OUD). However, the patterns of...
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The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside...
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Parent-reported phenotype data on chromosome 6 aberrations collected via an online questionnaire: data consistency and data availability
BackgroundEven with the introduction of new genetic techniques that enable accurate genomic characterization, knowledge about the phenotypic spectrum...
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Diagnostic Value of MRI Features in Dual-phenotype Hepatocellular Carcinoma: A Preliminary Study
This study aimed to explore the magnetic resonance imaging (MRI) features of dual-phenotype hepatocellular carcinoma (DPHCC) and their diagnostic...
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Experiences of people with multiple sclerosis and clinicians in using cognitive behavioural therapies for hidden symptoms: a systematic review and meta-aggregation
PurposeCognitive behavioural therapies (CBTs) are a standard of care for treatment of many ‘hidden symptoms’ in people with MS (PwMS), such as...
