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Can artificial intelligence overtake human intelligence on the bumpy road towards glioma therapy?
Gliomas are one of the most devastating primary brain tumors which impose significant management challenges to the clinicians. The aggressive...
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Successful pregnancy after prenatal diagnosis by NGS for a carrier of complex chromosome rearrangements
BackgroundThe study is aimed to provide prediction for fertility risk in the setting of assisted reproduction for a woman with complex chromosomal...
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Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review
Oral squamous cell carcinoma (OSCC), one of the most common types of cancers worldwide, is diagnosed mainly through tissue biopsy. However, owing to...
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Multidisciplinary treatment for infective endocarditis complicated with systemic multiple abscess due to Panton-Valentine leukocidin producing community-acquired methicillin-resistant Staphylococcus aureus and Candida albicans: a case report
BackgroundInfective endocarditis resulting from community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is a rare, but often fatal...
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Proteomic identification and quantification of Clostridium perfringens enterotoxin using a stable isotope-labelled peptide via liquid chromatography–tandem mass spectrometry
PurposeDetection of Clostridium perfringens enterotoxin (CPE) in human stool is critical evidence of food poisoning. However, processing...
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SCN1A overexpression, associated with a genomic region marked by a risk variant for a common epilepsy, raises seizure susceptibility
Mesial temporal lobe epilepsy with hippocampal sclerosis and a history of febrile seizures is associated with common variation at rs7587026, located...
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Chromosomal Copy Number Variation Analysis in Pregnancy Products from Recurrent and Sporadic Miscarriage Using Next-Generation Sequencing
Chromosomal abnormality is one of the causes of fetal miscarriage. The potential differences of fetal chromosomal abnormalities in sporadic...
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Emerging applications of phage therapy and fecal virome transplantation for treatment of Clostridioides difficile infection: challenges and perspectives
Clostridioides difficile , which causes life-threatening diarrheal disease, is considered an urgent threat to healthcare setting worldwide. The...
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The application of high-throughput sequencing technology in corneal diseases
High-throughput sequencing technology, also known as next-generation sequencing technology, can explore new biomarkers and specific gene mutations....
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Identification of rs2736099 as a novel cis-regulatory variation for TERT and implications for tumorigenesis and cell proliferation
PurposeLung cancer is a malignant tumor with obvious genetic predisposition. Association studies have proposed that rs2853677, a SNP localizing at...
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Patient centered guidelines for the laboratory diagnosis of Gaucher disease type 1
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder due to the deficient activity of the acid beta-glucosidase (GCase) enzyme,...
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Multiplex ligation-dependent probe amplification identifies copy number changes in normal and undetectable karyotype MDS patients
Chromosomal abnormalities play an important role in classification and prognostication of myelodysplastic syndrome (MDS) patients. However, more than...
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Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
Bacteria can evolve rapidly by acquiring new traits such as virulence, metabolic properties, and most importantly, antimicrobial resistance, through...
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Implication of gut microbes and its metabolites in colorectal cancer
BackgroundColorectal cancer (CRC) is the third most common cancer with a significant impact on loss of life. In 2020, nearly 1.9 million new cases...
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Molecular mechanisms augmenting resistance to current therapies in clinics among cervical cancer patients
Cervical cancer (CC) is the fourth leading cause of cancer death (~ 324,000 deaths annually) among women internationally, with 85% of these deaths...
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Applications of synthetic biology in medical and pharmaceutical fields
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have...
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Lorlatinib and capmatinib in a ROS1-rearranged NSCLC with MET-driven resistance: tumor response and evolution
Acquired drug resistance remains a major problem across oncogene-addicted cancers. Elucidation of mechanisms of resistance can inform rational...
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Biphenotypic Cells and α-Synuclein Accumulation in Enteric Neurons of Leucine-Rich Repeat Kinase 2 Knockout Mice
BackgroundLeucine-rich repeat kinase 2 is a molecule that is responsible for familial Parkinson’s disease. Our previous findings revealed that...
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Insights and implications of sexual dimorphism in osteoporosis
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and deterioration of bone microarchitecture, has led to a high risk...
