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BAP1-defficient breast cancer in a patient with BAP1 cancer syndrome
BAP1 cancer syndrome is a rare and highly penetrant hereditary cancer predisposition. Uveal melanoma, mesothelioma, renal cell carcinoma (RCC) and...
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MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis
Septic cardiomyopathy is one of the most severe and common complications in patients with sepsis and poses a great threat to their prognosis....
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The BAP1 nuclear deubiquitinase is involved in the nonhomologous end-joining pathway of double-strand DNA repair through interaction with DNA-PK
BRCA1-associated protein 1 (BAP1) has emerged as a major tumor suppressor gene in diverse cancer types, notably in malignant pleural mesothelioma...
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BAP1 in cancer: epigenetic stability and genome integrity
Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and in sporadic tumours. Individuals carrying familiar BAP1...
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BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms
The tumour suppressor BRCA1-associated protein 1 (BAP1) is the most frequently mutated cancer gene in mesothelioma. Here we report novel functions...
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Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis
BackgroundEmerging research has validated that circular RNAs (circRNAs) have indispensable regulatory functions in tumorigenesis, including...
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BAP1, Wilms’ tumor 1, and calretinin in predicting survival and response to first-line chemotherapy in patients with pleural mesothelioma
PurposeThere are currently no methods to predict response to chemotherapy in pleural mesothelioma (PM). The aim of this study is to investigate the...
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Peritoneal papillary mesothelioma in situ: BAP1 mutation with indolent behavior for 15 years
Papillary mesothelioma in situ (PMIS) is a rare and enigmatic disease. Most instances manifest as lesions of the peritoneal serosa. The pathogenesis...
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Loss of BAP1 Protein Expression by Immunohistochemistry in the Salivary Duct Carcinoma Component of an Intracapsular Carcinoma ex Pleomorphic Adenoma of the Parotid Gland
BackgroundBRCA1-associated protein 1 ( BAP1 ) is a tumor suppressor gene that is altered in a variety of neoplasms as well as in BAP1 tumor...
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PBRM1 and BAP1: novel genetic mutations in malignant transformation of craniopharyngioma—a case report
Malignant craniopharyngioma is especially rare, so the causes and genetic mutations associated with the malignant transformation have not been...
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BAP1-related signature predicts benefits from immunotherapy over VEGFR/mTOR inhibitors in ccRCC: a retrospective analysis of JAVELIN Renal 101 and checkmate-009/010/025 trials
BackgroundIn patients with advanced clear cell renal cell carcinoma, despite the undoubted benefits from immune checkpoint inhibitor (ICI)-based...
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Clinical and molecular validation of BAP1, MTAP, P53, and Merlin immunohistochemistry in diagnosis of pleural mesothelioma
BAP1 and MTAP immunostains play an important role in diagnosis of mesothelioma, but additional markers are needed to increase sensitivity. We...
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Mullerian adenosarcoma: clinicopathologic and molecular characterization highlighting recurrent BAP1 loss and distinctive features of high-grade tumors
Mullerian adenosarcoma is an uncommon mesenchymal tumor of the gynecologic tract. Most cases are low-grade, while high-grade adenosarcomas are rare...
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Therapeutic targeting of BAP1/ASXL3 sub-complex in ASCL1-dependent small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive disease, with patients diagnosed with either early-stage, limited stage, or extensive stage of SCLC...
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Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma
Effective therapeutic options are still lacking for uveal melanoma (UM) patients who develop metastasis. Metastatic traits of UM are linked to...
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Novel insights into the BAP1-inactivated melanocytic tumor
BAP1 -inactivated melanocytic tumor (BIMT) is a group of melanocytic neoplasms with epithelioid cell morphology molecularly characterized by the loss...
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PBRM1, SETD2 and BAP1 — the trinity of 3p in clear cell renal cell carcinoma
Biallelic inactivation of the tumour suppressor gene Von Hippel–Lindau ( VHL ) occurs in the vast majority of clear cell renal cell carcinoma (ccRCC)...
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BAP1 and PTEN mutations shape the immunological landscape of clear cell renal cell carcinoma and reveal the intertumoral heterogeneity of T cell suppression: a proof-of-concept study
Clear cell renal cell carcinoma (ccRCC) is an immunologically vulnerable tumor entity, and immune checkpoint inhibitors are now widely used to treat...
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BAP1 methylation: a prognostic marker of uveal melanoma metastasis
Uveal melanoma, the most common intraocular primary cancer in adults, is characterized by striking variability in metastatic tendencies . BAP1 ...
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5-hmC loss is another useful tool in addition to BAP1 and MTAP immunostains to distinguish diffuse malignant peritoneal mesothelioma from reactive mesothelial hyperplasia in peritoneal cytology cell-blocks and biopsies
The differentiation between reactive mesothelial hyperplasia (RMH) and diffuse malignant peritoneal mesothelioma (DMPM) is challenging especially...
