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Association between hyperCKemia and axonal degeneration in Guillain–Barré syndrome
BackgroundElevated serum creatine kinase (CK) levels have been reported in patients with Guillain–Barré syndrome (GBS), more frequently in patients...
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Chenodeoxycholic acid rescues axonal degeneration in induced pluripotent stem cell-derived neurons from spastic paraplegia type 5 and cerebrotendinous xanthomatosis patients
BackgroundBiallelic mutations in CYP27A1 and CYP7B1 , two critical genes regulating cholesterol and bile acid metabolism, cause cerebrotendinous...
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Axonal protection by combination of ripasudil and brimonidine with upregulation of p-AMPK in TNF-induced optic nerve degeneration
PurposeThe ROCK inhibitor ripasudil hydrochloride hydrate was shown to have axonal protective effects in TNF-induced optic nerve degeneration. The...
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Sex differences in the extent of acute axonal pathologies after experimental concussion
Although human females appear be at a higher risk of concussion and suffer worse outcomes than males, underlying mechanisms remain unclear. With...
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Chronic Demyelination and Axonal Degeneration in Multiple Sclerosis: Pathogenesis and Therapeutic Implications
Purpose of ReviewMultiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). Inflammatory attacks in MS...
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Inhibitory effect of parthenolide on peripheral nerve degeneration
Traumatic axonal damage disrupts connections between neurons, leading to the loss of motor and sensory functions. Although damaged peripheral nerves...
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Maculopapillary Bundle Degeneration in Optic Neuropathies
Purpose of ReviewDegeneration of the maculopapillary bundle (MPB) is a prominent feature in a spectrum of optic neuropathies. MPB-selective...
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Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice
Central nervous system axons have minimal capacity to regenerate in adult brains, hindering memory recovery in Alzheimer’s disease (AD). Although...
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Axonal degeneration in Guillain–Barré syndrome: a reappraisal
The aim of this review was to analyse the pathophysiology of axonal degeneration in Guillain–Barré syndrome (GBS) with emphasis on early stages...
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Myelin degradation, axonal changes and expression trajectories of glial cells stimulated by rapid head insult in humans to estimate approximate time elapsed since trauma
BackgroundPost severe traumatic brain injury (sTBI), axonal alterations lead to myelin loss and its degeneration. In the recovery phase, numerous...
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Neurofilament light chain levels indicate acute axonal damage under bortezomib treatment
IntroductionBortezomib (BTZ) is a selective and reversible proteasome inhibitor and first line treatment for multiple myeloma (MM). One of the side...
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Loss of function of FIP200 in human pluripotent stem cell-derived neurons leads to axonal pathology and hyperactivity
FIP200 plays important roles in homeostatic processes such as autophagy and signaling pathways such as focal adhesion kinase (FAK) signaling....
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Mucoid Degeneration of the Ulnar Nerve
Peripheral nerve mucoid degeneration is a rare, non-neoplastic, localised degenerative condition of the peripheral nerve, characterised by endoneural...
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Hypertrophic olivary degeneration following head injury: a case report
BackgroundHypertrophic olivary degeneration (HOD) is a unique type of neuronal degeneration presenting as hypertrophy, in contrast to atrophy as seen...
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Activating cannabinoid receptor 2 preserves axonal health through GSK-3β/NRF2 axis in adrenoleukodystrophy
Aberrant endocannabinoid signaling accompanies several neurodegenerative disorders, including multiple sclerosis. Here, we report altered...
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Occurrence of corneal sub-epithelial microneuromas and axonal swelling in people with diabetes with and without (painful) diabetic neuropathy
Aims/hypothesisNon-invasive in vivo corneal confocal microscopy is gaining ground as an alternative to skin punch biopsy to evaluate small-diameter...
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Subacute Degeneration of Fibers After Vertical Parasagittal Hemispherotomy
PurposeAfter vertical parasagittal hemispherotomy a restricted diffusion is often seen ipsilaterally and even distant from the adjacent resection...
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Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies
Traumatic brain injury (TBI) has high morbidity and poor prognosis and imposes a serious socioeconomic burden. Traumatic axonal injury (TAI), which...
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Neurofilament light chains in serum as biomarkers of axonal damage in early MS lesions: a histological–serological correlative study
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease associated with axonal injury, and neurofilament light chains in serum (sNfL)...
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Clinical, imaging and histopathological characterization of a series of three cats with cerebellar cortical degeneration
BackgroundNeurological inherited disorders are rare in domestic animals. Cerebellar cortical degeneration remains amongst the most common of these...
