Search
Search Results
-
Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients
BackgroundThe defective clearance of apoptotic bodies in juvenile-onset systemic lupus erythematosus (jSLE) potentially leads to the persistence of...
-
From risk to chronicity: evolution of autoreactive B cell and antibody responses in rheumatoid arthritis
The presence of disease-specific autoantibody responses and the efficacy of B cell-targeting therapies in rheumatoid arthritis (RA) indicate a...
-
Circulating lymphocyte subpopulations in patients with systemic lupus erythematosus and their correlation with disease activity
The aim of the present study was to evaluate the overall alterations of peripheral blood lymphocyte subsets in patients with systemic lupus...
-
Characteristics and clustering analysis of peripheral blood lymphocyte subsets in children with systemic lupus erythematosus complicated with clinical infection
ObjectivesClinical infection is a common complication in children with systemic lupus erythematosus (SLE). However, few studies have investigated...
-
The pathophysiologic significance of lymphocyte subset determination in children with infectious mononucleosis, mycoplasma pneumonia and Henoch–Schönlein purpura
ObjectiveThis study aimed to explore lymphocyte subset determinations as an aid to understanding the pathophysiology of infectious mononucleosis...
-
Noninvasive approach to indicate risk factors of nonalcoholic steatohepatitis overlap** autoimmune hepatitis based on peripheral lymphocyte pattern
BackgroundNonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) clinically includes autoimmunity as indicated by antinuclear...
-
B-lymphocyte-activating factor is a potential biomarker associated with susceptibility to Graves’ disease in Iraqi women
BackgroundB-lymphocyte-activating factor (BAFF) is a cytokine involved in regulating the development and maturation of B lymphocyte and has been...
-
miR-142-3p encapsulated in T lymphocyte-derived tissue small extracellular vesicles induces Treg function defect and thyrocyte destruction in Hashimoto’s thyroiditis
BackgroundHashimoto’s thyroiditis (HT) is an organ-specific autoimmune disease characterized by lymphocyte infiltration that destroys thyrocyte...
-
Regulatory T-lymphocyte subsets in children with chronic immune thrombocytopenia after high-dose of dexamethasone
BackgroundImmune thrombocytopenia (ITP) is an acquired autoimmune disease. This study’s objective was to estimate the variations in the population of...
-
Importance of lymphocyte–stromal cell interactions in autoimmune and inflammatory rheumatic diseases
Interactions between lymphocytes and stromal cells have an important role in immune cell development and responses. During inflammation, stromal...
-
Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice
Aims/hypothesisStimulator of IFN genes (STING) is a central hub for cytosolic nucleic acid sensing and its activation results in upregulation of type...
-
Mechanisms and biomarkers of immune-related adverse events in gastric cancer
Immune-checkpoint inhibitors (ICIs), different from traditional cancer treatment models, have shown unprecedented anti-tumor effects in the past...
-
tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice
Aims/hypothesistRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA...
-
Targeted Small Molecules for Systemic Lupus Erythematosus: Drugs in the Pipeline
Despite the uncertainty of the pathogenesis of systemic lupus erythematosus, novel small molecules targeting specific intracellular mechanisms of...
-
Lymphocyte subset abnormalities in early diffuse cutaneous systemic sclerosis
BackgroundAbnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound,...
-
Mitochondria in the Pathogenesis of Systemic Lupus Erythematosus
Purpose of ReviewSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and inflammation in multiple...
-
Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children
Aims/hypothesisType 1 diabetes is an autoimmune disorder that is characterised by destruction of pancreatic beta cells by autoreactive T lymphocytes....
-
IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis
The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management....
-
Patients with systemic sclerosis and low CD4 numbers after autologous stem cell transplantation have a favorable outcome
BackgroundTreatment with high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (aHSCT) is an intensive treatment...
-
Lymphocyte subpopulations in Sjögren’s syndrome are distinct in anti-SSA-positive patients and related to disease activity
ObjectivesSjögren’s syndrome (SjS) patients exhibit great phenotypical heterogeneity, reinforced by the positiveness of anti-SSA antibody. We aimed...
