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Should We Use bDMARDs as an Induction Therapy in Early and Severe Rheumatoid Arthritis? Results at 5 years from the ERA UCLouvain Brussels Cohort
IntroductionThis study sought to analyze the benefit of an early induction therapy with a biological disease-modifying anti-rheumatic drugs (bDMARD)...
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Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and sco** review
BackgroundTo determine the prevalence of sustained remission/low disease activity (LDA) in patients with rheumatoid arthritis (RA) after...
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Increased gut permeability and intestinal inflammation precede arthritis onset in the adjuvant-induced model of arthritis
BackgroundIntestinal inflammation, dysbiosis, intestinal permeability (IP), and bacterial translocation (BT) have been identified in patients with...
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Inhibitory effects of Acanthopanax sessiliflorus Harms extract on the etiology of rheumatoid arthritis in a collagen-induced arthritis mouse model
BackgroundThe biological function of Acanthopanax sessiliflorus Harm (ASH) has been investigated on various diseases; however, the effects of ASH on...
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Immune mechanisms of depression in rheumatoid arthritis
Depression is a common and disabling comorbidity in rheumatoid arthritis that not only decreases the likelihood of remission and treatment adherence...
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Some Drugs Have Two Faces: Paradoxical Colitis in a Patient with Psoriatic Arthritis Previously Treated with Etanercept and IL-17 Inhibitors
Tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) inhibitors are among the most potent treatments for inflammatory arthropathies...
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Treatment of systemic juvenile idiopathic arthritis
Systemic juvenile idiopathic arthritis (sJIA) is an inflammatory disease with hallmarks of severe systemic inflammation, which can be accompanied by...
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Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention
Rheumatoid arthritis (RA) is a worldwide public health problem. Interventions to delay or prevent the onset of RA have attracted much attention in...
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Immunologic derangement caused by intestinal dysbiosis and stress is the intrinsic basis of reactive arthritis
Reactive arthritis (ReA) is defined as arthritis resulting from infections in other body parts, such as the gastrointestinal and urogenital tracts....
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Differences between psoriatic arthritis and psoriasis in multi-omics
We aim to systemically review the genomics, transcriptomics, epigenetics, proteomics, metabonomics and microbiota of psoriatic arthritis and...
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Innate immune memory in inflammatory arthritis
The concept of immunological memory was demonstrated in antiquity when protection against re-exposure to pathogens was observed during the plague of...
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Dupilumab-Associated Arthritis: A Dermatology-Rheumatology Perspective
Dupilumab is an interleukin (IL)-4/13 inhibitor approved by the US FDA for multiple atopic indications. It is well-known to have favorable efficacy...
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Microbial Mechanisms of Rheumatoid Arthritis Pathogenesis
Purpose of ReviewHost-microbiome interactions have been implicated in the pathophysiology of rheumatoid arthritis (RA), but the data linking specific...
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Joint-specific memory, resident memory T cells and the rolling window of opportunity in arthritis
In rheumatoid arthritis, juvenile idiopathic arthritis and other forms of inflammatory arthritis, the immune system targets certain joints but not...
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Influenza Adverse Events in Patients with Rheumatoid Arthritis, Ulcerative Colitis, or Psoriatic Arthritis in the Tofacitinib Clinical Development Programs
IntroductionThis post hoc analysis evaluated influenza adverse events (AEs) across rheumatoid arthritis (RA), ulcerative colitis (UC), and psoriatic...
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Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis
BackgroundSynovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological aberration of glycolysis and glutaminolysis. Henceforth, we...
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Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis
ObjectiveFibroblast-like synoviocytes (FLS) play a critical role on the exacerbation and deterioration of rheumatoid arthritis (RA). Aberrant...
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Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons
BackgroundJanus kinase (JAK) inhibitors, such as baricitinib, are widely used to treat rheumatoid arthritis (RA). Clinical studies show that...
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Matrix metalloproteinases in arthritis: towards precision medicine
Proteolysis of structural molecules of the extracellular matrix (ECM) is an irreversible post-translational modification in all arthropathies. Common...
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Drug- or Vaccine-Induced/Aggravated Psoriatic Arthritis: A Systematic Review
IntroductionDrugs and vaccines have been less studied as inducing or aggravating factors for psoriatic arthritis (PsA) compared with psoriasis. Thus,...
