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Inhibitors of apolipoprotein C3, triglyceride levels, and risk of pancreatitis: a systematic review and meta-analysis
In recent years, novel apoC3 inhibitor therapies for the treatment of hypertriglyceridemia have been developed and assessed through phase II and III...
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The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis
BackgroundModulators of triglyceride metabolism include lipoprotein lipase (LPL), angiopoietin-like protein 4 (ANGPTL4), and apolipoprotein C-3...
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Ipragliflozin and sitagliptin differentially affect lipid and apolipoprotein profiles in type 2 diabetes: the SUCRE study
BackgroundSGLT2 inhibitors and DPP4 inhibitors have been suggested to affect lipid metabolism. However, there are few randomized controlled trials...
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Role of apolipoprotein C1 in lipoprotein metabolism, atherosclerosis and diabetes: a systematic review
Apolipoprotein C1 (apoC1) is a small size apolipoprotein whose exact role is not totally clarified but which seems to modulate significantly the...
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Effects of belimumab on the lipid profile in systemic lupus erythematosus patients: an observational study
This study is asked to investigate the effects of belimumab on the lipid profile in systemic lupus erythematosus (SLE) patients. Forty-one SLE...
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Evaluating the Effectiveness and Safety of Evinacumab in Treating Hypercholesterolemia and Hypertriglyceridemia: A Systematic Review and Meta-analysis of Randomized Controlled Trials
BackgroundCardiovascular disease remains a significant global health concern, with high low-density lipoprotein cholesterol (LDL-C) levels...
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Effect of dapagliflozin on proteomics and metabolomics of serum from patients with type 2 diabetes
BackgroundSodium-glucose co-transporter 2 (SGLT2) inhibitors reduced the risk of cardiovascular and renal outcomes in patients with type 2 diabetes...
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Multiplexed MRM-based proteomics for identification of circulating proteins as biomarkers of cardiovascular damage progression associated with diabetes mellitus
BackgroundType 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial...
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Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies
Purpose of ReviewFibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria....
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Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?
Numerous genetic and epidemiologic studies have demonstrated an association between elevated levels of lipoprotein(a) (Lp[a]) and cardiovascular...
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The Role of RNA-Targeted Therapeutics to Reduce ASCVD Risk: What Have We Learned Recently?
Purpose of ReviewTo discuss advances on the RNA-targeted therapies to treat dyslipidemia with the aim of reducing atherosclerotic cardiovascular...
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Childhood Hypertriglyceridemia: Is It Time for a New Approach?
Purpose of ReviewHypertriglyceridemia (HTG) is widely prevalent in youth. There is an unmet need for effective medications in the management of HTG...
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A case report of youth-onset lipoprotein glomerulopathy with APOE Chicago mutation
BackgroundThis article reports an extremely rare case of lipoprotein glomerulopathy (LPG) with apolipoprotein E gene ( APOE ) Chicago mutation in a...
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Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study
IntroductionMigraine, a prevalent headache disorder with unclear mechanisms and limited treatments, may be influenced by dyslipidemia and genetic...
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Do Triglyceride-Rich Lipoproteins Equal Low-Density Lipoproteins in Risk of ASCVD?
Purpose of ReviewRecent large clinical trials have failed to show that triglyceride-rich lipoprotein-lowering therapies decrease the risk of...
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Highlights of Cardiovascular Disease Prevention Studies Presented at the 2024 American College of Cardiology Conference
Purpose of ReviewTo summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2024 Scientific Session of...
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Structure-based mechanism and inhibition of cholesteryl ester transfer protein
Purpose of ReviewCholesteryl ester transfer proteins (CETP) regulate plasma cholesterol levels by transferring cholesteryl esters (CEs) among...
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APOC-III: a Gatekeeper in Controlling Triglyceride Metabolism
Purpose of ReviewApolipoprotein C-III (ApoC-III) is a widely known player in triglyceride metabolism, and it has been recently recognized as a...
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Proteomics of high-density lipoprotein subfractions and subclinical atherosclerosis in type 1 diabetes mellitus: a case–control study
BackgroundSubclinical atherosclerosis is frequently observed in type 1 diabetes (T1D) although the mechanisms and markers involved in the evolution...
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Fibrates, Hypertriglyceridemia, and CVD Risk: Where Do We Stand After the PROMINENT Trial for Triglyceride Lowering?
Purpose of ReviewTo evaluate recent clinical trials focusing on patients with hypertriglyceridemia.
Recent FindingsRandomized clinical trials have...
