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Targeting DNA polymerase β elicits synthetic lethality with mismatch repair deficiency in acute lymphoblastic leukemia
Mismatch repair (MMR) deficiency has been linked to thiopurine resistance and hypermutation in relapsed acute lymphoblastic leukemia (ALL). However,...
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Lethality risk markers by sex and age-group for COVID-19 in Mexico: a cross-sectional study based on machine learning approach
BackgroundMexico ranks fifth worldwide in the number of deaths due to COVID-19. Identifying risk markers through easily accessible clinical data...
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A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency
E7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA splicing by degrading the splicing factor RBM39 via ternary complex...
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Early embryonic lethality in complex I associated p.L104P Nubpl mutant mice
BackgroundVariants in the mitochondrial complex I assembly factor, NUBPL are associated with a rare cause of complex I deficiency mitochondrial...
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Aurora kinase A inhibition induces synthetic lethality in SMAD4-deficient colorectal cancer cells via spindle assembly checkpoint activation
SMAD4 loss-of-function mutations have been frequently observed in colorectal cancer (CRC) and are recognized as a drug target for therapeutic...
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Genetic animal modeling for idiopathic scoliosis research: history and considerations
PurposeIdiopathic scoliosis (IS) is defined as a structural lateral spinal curvature ≥ 10° in otherwise healthy children and is the most common...
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Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
The molecular features that define clear cell renal cell carcinoma (ccRCC) initiation and progression are being increasingly defined. The TRACERx...
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Hydrocortisone decreases lethality and inflammatory cytokine and nitric oxide production in rats challenged with B. anthracis cell wall peptidoglycan
BackgroundLethal B. anthracis infection produces high proinflammatory peptidoglycan (PGN) burdens in hosts. We investigated whether the lethality...
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Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy
Influenza-associated encephalopathy (IAE) is extremely acute in onset, with high lethality and morbidity within a few days, while the direct...
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p53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain)
Recurrent cytogenetic abnormalities are the main hallmark of multiple myeloma (MM) and patients having 2 or more high-risk prognostic events are...
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Effect of Abelmoschus ficulneus (L.) Wight & Arn. on immunomodulation: in vivo experimental animal models
BackgroundAbelmoschus ficulneus (L.) Wight & Arn. (Malvaceae) commonly known as herb in the Ayurveda, Indian traditional medicine system. Herb is...
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RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia
Despite recent advances in acute myeloid leukemia (AML) molecular characterization and targeted therapies, a majority of AML cases still lack...
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CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas
Somatic mutations affecting CREBBP and EP300 are a hallmark of diffuse large B-cell lymphoma (DLBCL). These mutations are frequently monoallelic,...
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Synthetic lethality between MyD88 loss and mutations in Wnt/β-catenin pathway in intestinal tumor epithelial cells
Although the Wnt/β-catenin pathway plays a central role in the carcinogenesis and maintenance of colorectal cancer (CRC), attempts to target the...
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Acute and sub-chronic toxicity assessment and evaluation of the gastro-protective activity of polyherbal formulation “Mystomate4®” against gastric ulcer in experimental laboratory animal
BackgroundUlcer remains a health challenge worldwide with antibiotics and proton pump inhibitors as major management therapy. The study investigated...
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Synergistic lethality between PARP-trap** and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells
PARP1 and PARP2 play critical roles in regulating DNA repair and PARP inhibitors have been approved for the treatment of BRCA1/2-mutated ovarian and...
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SEC31A may be associated with pituitary hormone deficiency and gonadal dysgenesis
PurposeDisorders/differences of sex development (DSD) result from variants in many different human genes but, frequently, have no detectable...
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Antioxidant property, haematinic and biosafety effect of Ipomoea batatas lam. leaf extract in animal model
BackgroundPlant medicine was dated back for decades and has immensely contributed to the health care system in several countries. This present study...
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The in vivo toxicity evaluation of leaf and root methanolic extracts of Tephrosia vogelii Hook.f using animal model
BackgroundTraditionally, herbal medicines are commonly used to cure several diseases since immemorial of human life. Nevertheless, the safety of some...
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Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review
BackgroundAnimal models of COVID-19 have been rapidly reported after the start of the pandemic. We aimed to assess whether the newly created models...
