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RNA N6-methyladenosine-modified-binding protein YTHDF1 promotes prostate cancer progression by regulating androgen function-related gene TRIM68
PurposeThere is no report about the direct relationship between m6A modification and androgen receptor (AR)-related genes in prostate cancer (PC). We...
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Selective targeting of the androgen receptor-DNA binding domain by the novel antiandrogen SBF-1 and inhibition of the growth of prostate cancer cells
Prostate cancers are reliant on androgens for growth and survival. Clinicians and researchers are looking for potent treatments for the resistant...
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Dietary fat quality and serum androgen concentrations in middle-aged men
Background/ObjectivesAverage testosterone concentrations in men have declined over the last few decades. The reasons for this are not fully known,...
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SC912 inhibits AR-V7 activity in castration-resistant prostate cancer by targeting the androgen receptor N-terminal domain
Androgen deprivation therapies (ADT) are the mainstay treatments for castration-resistant prostate cancer (CRPC). ADT suppresses the androgen...
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Protein degraders enter the clinic ā a new approach to cancer therapy
Heterobifunctional protein degraders, such as PROteolysis TArgeting Chimera (PROTAC) protein degraders, constitute a novel therapeutic modality that...
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Protective effects of Allium cepa-fortified feed on testicular function alterations by potassium bromate-induced oxidative damage: an in vivo and in silico approach
Human infertility can arise from various factors including oxidative stress and endocrine disruptors. This study evaluated the protective effects of Al...
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The androgen receptor-targeted proteolysis targeting chimera and other alternative therapeutic choices in overcoming the resistance to androgen deprivation treatment in prostate cancer
Androgen receptor (AR) plays a vital role in prostate cancer (PCa), including castration-resistant PCa, by retaining AR signalling. Androgen...
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Protein translation: biological processes and therapeutic strategies for human diseases
Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. The deregulation of this...
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Fundamental concepts of protein therapeutics and spacing in oncology: an updated comprehensive review
Current treatment regimens in cancer cases cause significant side effects and cannot effectively eradicate the advanced disease. Hence, much effort...
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Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019ā2023
Open access to three-dimensional atomic-level biostructure information from the Protein Data Bank (PDB) facilitated discovery/development of 100% of...
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Targeted protein degradation: mechanisms, strategies and application
Traditional drug discovery mainly focuses on direct regulation of protein activity. The development and application of protein activity modulators,...
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Retinol and retinol binding protein 4 levels and COVID-19: a Mendelian randomization study
BackgroundThe Corona Virus Disease 2019 (COVID-19) pandemic has struck globally. Whether the related proteins of retinoic acid (RA) signaling pathway...
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Interleukin-22/Interleukin-22 binding protein axis and oral contraceptive use in polycystic ovary syndrome
PurposePolycystic ovary syndrome (PCOS) is associated with alterations in gut microbiota. The cytokine interleukin-22 (IL-22) is produced by immune...
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A new role of GRP75-USP1-SIX1 protein complex in driving prostate cancer progression and castration resistance
Prostate cancer (PC) is the second most common cancer with limited treatment option in males. Although the reactivation of embryonic signals in adult...
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AKT1 regulates UHRF1 protein stability and promotes the resistance to abiraterone in prostate cancer
Oncogenic activation of PI3K/AKT signaling pathway, together with epigenetic aberrations are the characters of castration-resistant prostate cancer...
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Protein acylation: mechanisms, biological functions and therapeutic targets
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and...
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Targeting a splicing-mediated drug resistance mechanism in prostate cancer by inhibiting transcriptional regulation by PKCĪ²1
The androgen receptor (AR) is a central driver of aggressive prostate cancer. After initial treatment with androgen receptor signaling inhibitors...
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Effects of high-protein diets on the cardiometabolic factors and reproductive hormones of women with polycystic ovary syndrome: a systematic review and meta-analysis
The optimal dietary regimen for polycystic ovary syndrome (PCOS) has not been identified. High-protein diets (HPDs) are effective for weight control...
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Sex-related differences of fatty acid-binding protein 4 and leptin levels in atrial fibrillation: an updated review
Atrial fibrillation (AF) is a prevalent cardiac arrhythmia affecting millions of individuals worldwide and posing significant challenges to...
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Alterations in the balance of sex hormones may affect rat prostatic inflammation and fibrosis, and osteopontin might be involved in this process
ObjectiveThis study aimed to investigate the effects of sex hormone imbalance on rat prostatic inflammation and fibrosis and identify the key...
