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Neopentyl glycol-based radiohalogen-labeled amino acid derivatives for cancer radiotheranostics
BackgroundL-type amino acid transporter 1 (LAT1) is overexpressed in various cancers; therefore, radiohalogen-labeled amino acid derivatives...
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L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
Oncometabolites, such as D/L-2-hydroxyglutarate (2HG), have directly been implicated in carcinogenesis; however, the underlying molecular mechanisms...
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Protein content and amino acid composition in the diet of Danish vegans: a cross-sectional study
BackgroundA growing proportion of the population are replacing their dietary animal protein with plant protein. A particular example of this trend is...
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Prognostic value of amino acid metabolism-related gene expression in invasive breast carcinoma
BackgroundAn increasing number of studies indicated that metabolic reprogramming of amino acid metabolism may either promote or inhibit tumor...
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Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
ObjectivesDietary restriction of methionine (Met) and cysteine (Cys) delays the aging process and aging-related diseases, improves glucose and fat...
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Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients
PurposeThe changes in serum amino acid profiles are evaluated in different types of cancers and screening tests were developed for estimating the...
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Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs
BackgroundAs a nutritive feed additive, guanidine acetic acid (GAA) participates in the metabolism of energy and proteins. This study aimed to...
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Repeated amino acid PET imaging for longitudinal monitoring of brain tumors
PurposeAmino acid PET is a useful complement to MRI in a number of clinical settings for the evaluation of brain tumors. However, amino acid PET is...
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Amino acid availability enhanced through glucose coadministration of amino acid supplementation during hemodiafiltration: two case reports
BackgroundIntravenous administration of amino acid (AA) formulation (IVAA) as intradialytic parenteral nutrition is widely used for malnourished...
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Prospective investigation of amino acid transport and PSMA-targeted positron emission tomography for metastatic lobular breast carcinoma
PurposeTo explore the feasibility of imaging amino-acid transport and PSMA molecular pathways in the detection of metastatic breast invasive lobular...
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HIV-1 Tat amino acid residues that influence Tat-TAR binding affinity: a sco** review
HIV-1 remains a global health concern and to date, nearly 38 million people are living with HIV. The complexity of HIV-1 pathogenesis and its...
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Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Aim/hypothesisHyperglycaemia is associated with alpha cell dysfunction, leading to dysregulated glucagon secretion in type 1 and type 2 diabetes;...
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Carrier frequency and incidence of aromatic L-amino acid decarboxylase deficiency: a gnomAD-based study
BackgroundAromatic L-amino acid decarboxylase (AADC) deficiency is an autosomal recessive neurotransmitter metabolism disorder and is clinically...
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Depression promotes breast cancer progression by regulating amino acid neurotransmitter metabolism and gut microbial disturbance
IntroductionBreast cancer (BC) is the most prevalent type of cancer and has the highest mortality among women worldwide. BC patients have a high risk...
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Differences in branched-chain amino acid to tyrosine ratio (BTR) among etiologies of chronic liver disease progression compared to healthy adults.
BackgroundThe branched-chain amino acids (BCAAs) to tyrosine (Tyr) ratio (BTR) test is used to evaluate the progression of chronic liver disease...
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Dietary amino acid intake and sleep duration are additively involved in future cognitive decline in Japanese adults aged 60 years or over: a community-based longitudinal study
BackgroundSleep duration and amino acid intake are independently associated with cognitive decline. This study aimed to determine the longitudinal...
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Maternal glycemic status during pregnancy and mid-childhood plasma amino acid profiles: findings from a multi-ethnic Asian birth cohort
BackgroundIncreasing maternal glycaemia across the continuum during pregnancy may predispose offspring to subsequent cardiometabolic risk later in...
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Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
BackgroundAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids...
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Effects of amino acid supplementation on muscle mass, muscle performance and functional capacity in subjects undergoing total knee arthroplasty: a systematic review of randomized clinical trials
The aim of the present study was to summarize the effectiveness of amino acid supplementation on muscle strength, muscle volume, and functional...
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Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography
BackgroundOverexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic...
