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Alternative splicing in prostate cancer progression and therapeutic resistance
Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men. CaP mortality results from diverse molecular mechanisms that...
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The role of alternative splicing in lung cancer
Aberrant alternative splicing (AS) events are frequently observed in lung cancer, which can be attributed to aberrant gene AS, alterations in...
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Targeting alternative splicing as a new cancer immunotherapy-phosphorylation of serine arginine-rich splicing factor (SRSF1) by SR protein kinase 1 (SRPK1) regulates alternative splicing of PD1 to generate a soluble antagonistic isoform that prevents T cell exhaustion
BackgroundRegulation of alternative splicing is a new therapeutic approach in cancer. The programmed cell death receptor 1 (PD-1) is an...
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Alternative splicing and related RNA binding proteins in human health and disease
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein...
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RNA alternative splicing impacts the risk for alcohol use disorder
Alcohol use disorder (AUD) is a complex genetic disorder characterized by problems arising from excessive alcohol consumption. Identifying functional...
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Decoding the role of aberrant RNA alternative splicing in hepatocellular carcinoma: a comprehensive review
During eukaryotic gene expression, alternative splicing of messenger RNA precursors is critical in increasing protein diversity and regulatory...
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METTL3 regulates breast cancer-associated alternative splicing switches
Alternative splicing (AS) enables differential inclusion of exons from a given transcript, thereby contributing to the transcriptome and proteome...
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MYCN and SNRPD3 cooperate to maintain a balance of alternative splicing events that drives neuroblastoma progression
Many of the pro-tumorigenic functions of the oncogene MYCN are attributed to its regulation of global gene expression programs. Alternative splicing...
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Alternative splicing variants involved in pyroptosis and cuproptosis contribute to phenotypic remodeling of the tumor microenvironment in cervical cancer
Cervical cancer (CC) remains a prevalent gynecological malignancy, posing a significant health burden among women worldwide. With the remarkable...
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LncRNA CACClnc promotes chemoresistance of colorectal cancer by modulating alternative splicing of RAD51
Long non-coding RNAs (lncRNAs) play important roles in carcinogenesis. However, the effect of lncRNA on chemoresistance and RNA alternative splicing...
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BCAS2 regulates granulosa cell survival by participating in mRNA alternative splicing
BackgroundGranulosa cell proliferation and differentiation are essential for follicle development. Breast cancer amplified sequence 2 (BCAS2) is...
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Role of the histone variant H2A.Z.1 in memory, transcription, and alternative splicing is mediated by lysine modification
Creating long-lasting memories requires learning-induced changes in gene expression, which are impacted by epigenetic modifications of DNA and...
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Candidate genes and their alternative splicing may be potential biomarkers of acute myocardial infarction: a study of mouse model
BackgroundAcute myocardial infarction (AMI) is one of the leading causes of death in human being, and an effective diagnostic biomarker is still...
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Alternative splicing in mouse brains affected by psychological stress is enriched in the signaling, neural transmission and blood-brain barrier pathways
Psychological stress increases the risk of major psychiatric disorders. Psychological stress on mice was reported to induce differential gene...
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Identification of prognostic alternative splicing signature in gastric cancer
BackgroundAberrant alternative splicing (AS) events could be viewed as prognostic indicators in a large number of malignancies. This study aims to...
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A pan-cancer analysis of alternative splicing of splicing factors in 6904 patients
Great progress has been made in the investigation on mutation and expression of splicing factor. However, little is known on the role of alternative...
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Regulatory roles of alternative splicing at Ezh2 gene in mouse oocytes
BackgroundEnhancer of zeste homologue 2 (EZH2), the core member of polycomb repressive complex 2 (PRC2), has multiple splicing modes and performs...
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Alternative splicing patterns reveal prognostic indicator in muscle-invasive bladder cancer
BackgroundBladder cancer is one of the most lethal malignancy in urological system, and 20–25% of bladder cancer patients are muscle invasive with...
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Effects of alternative splicing events and transcriptome changes on kidney stone formation
During the development of urinary stone disease, the formation of tiny crystals that adhere to the renal tubular epithelium induces epithelial cell...
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β-Arrestin2 promotes docetaxel resistance of castration-resistant prostate cancer via promoting hnRNP A1-mediated PKM2 alternative splicing
PurposeTo investigate the influence of β-arrestin2 on the docetaxel resistance in castration-resistant prostate cancer (CRPC) and elucidate the...
