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The association and prediction value of acylcarnitine on diabetic nephropathy in Chinese patients with type 2 diabetes mellitus
BackgroundAcylcarnitines play a role in type 2 diabetes mellitus (T2DM), but the relationship between acylcarnitine and diabetic nephropathy was...
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Instability of acylcarnitine and amino acids in dried blood spots preserved at various temperatures: the impact on retrospective analysis of inborn errors of metabolism biomarkers
Stored dried blood spots (DBSs) give significant specimens for retrospective detection of inborn errors of metabolisms (IEM) including for validation...
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Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia
BackgroundSarcopenia is defined as the disease of muscle loss and dysfunction. The prevalence of sarcopenia is strongly age-dependent. It could bring...
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Specific lysophosphatidylcholine and acylcarnitine related to sarcopenia and its components in older men
BackgroundMetabolic profiling may provide insights into the pathogenesis and identification of sarcopenia; however, data on the metabolic basis of...
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Exploring the prognostic significance of blood carnitine and acylcarnitines in hepatitis C virus-induced hepatocellular carcinoma
BackgroundHepatic energy metabolism is intricately linked with the metabolic changes associated with HCV infection and hepatocellular carcinoma...
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Adult-onset carnitine palmitoyl transferase II (CPT II) deficiency presenting with rhabdomyolysis and acute kidney injury
Metabolic myopathies are among the treatable causes of rhabdomyolysis and myoglobinuria. Carnitine palmitoyl transferase 2 (CPT II) deficiency is one...
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Longitudinal associations of pre-pregnancy BMI and gestational weight gain with maternal urinary metabolites: an NYU CHES study
Background/ObjectivesExcessive gestational weight gain (GWG) and pre-pregnancy obesity affect a significant portion of the US pregnant population and...
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Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry
BackgroundThe circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with...
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Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease
BackgroundDiabetes mellitus (DM) and coronary artery disease (CAD) constitute inter-related clinical entities. Biomarker profiling emerges as a...
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Inflammation, mitochondrial dysfunction and physical performance: a possible association in older patients with persistent atrial fibrillation—the results of a preliminary study
BackgroundAtrial fibrillation (AF) is associated with chronic inflammation, a hallmark of ageing process. The aim of this study was to determine...
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Ethylmalonic Encephalopathy: a literature review and two new cases of mild phenotype
BackgroundEthylmalonic encephalopathy (EE) is a rare intoxication-type metabolic disorder with multisystem involvement. It is caused by mutations in ETHE1...
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Associations of maternal plasma and umbilical cord plasma metabolomics profiles with birth anthropometric measures
BackgroundThe metabolomics profiles of maternal plasma during pregnancy and cord plasma at birth might influence fetal growth and birth...
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Metabolic factors associated with incident fracture among older adults with type 2 diabetes mellitus: a nested case–control study
SummaryOlder adults with type 2 diabetes mellitus have an increased risk of fracture despite a paradoxically higher average bone mineral density....
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Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome
BackgroundFatty acid oxidation (FAO) defects have been implicated in experimental models of acute lung injury and associated with poor outcomes in...
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Retrospective analysis of reference intervals for dried blood spot based ms/ms newborn screening programs in Chinese preterm neonates: a nationwide study
ObjectivesAlthough recent discoveries regarding the biomarkers of newborn screening (NBS) programs by tandem mass spectrometry (MS/MS) highlight the...
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Effects of short-term moderate intensity exercise on the serum metabolome in older adults: a pilot randomized controlled trial
BackgroundWe previously reported changes in the serum metabolome associated with impaired myocardial relaxation in an asymptomatic older community...
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Severity estimation of very-long-chain acyl-CoA dehydrogenase deficiency via 13C-fatty acid loading test
BackgroundThe clinical severity of very-long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is difficult to predict using conventional diagnostic...
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Clinical and Genetic Spectrum of 50 Children with Inborn Errors of Metabolism from Central India
This is a single-center, retrospective analysis of children confirmed to have an inborn error of metabolism in the pediatric department of a teaching...
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Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study
BackgroundCell stress promotes degradation of mitochondria which release danger-associated molecular patterns that are catabolized to N -formylmethion...
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Circulating amino acids and acylcarnitines correlated with different CAC score ranges in diabetic postmenopausal women using LC–MS/MS based metabolomics approach
BackgroundDiabetes mellitus (DM) and its cardiovascular disease (CVD) complication are among the most frequent causes of death worldwide. However,...
