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Acute graft-versus-host disease
Acute graft-versus-host disease (GVHD) is a common immune complication that can occur after allogeneic haematopoietic cell transplantation (alloHCT)....
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Acute Graft-versus-Host Disease: An Update on New Treatment Options
Acute graft-versus-host disease (GVHD) occurs in approximately 50% of patients and remains a primary driver of non-relapse and transplant-related...
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The diagnostic conundrum of acute cutaneous graft-versus-host disease: biomarkers remain elusive
Hematopoietic stem cell transplantation is increasing in frequency with graft-versus-host disease affecting many recipients. When the skin is...
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Real-world experience with ruxolitinib therapy for steroid-refractory acute graft versus host disease
Acute graft versus host disease (aGVHD) is a complication of allogeneic hematopoietic stem cell transplant (HCT) and is associated with significant...
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Ruxolitinib for the treatment of acute graft-versus-host disease: a retrospective analysis
Steroid-refractory acute graft-versus-host disease (aGvHD) is a serious complication after allogeneic hematopoietic stem cell transplantation,...
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Ruxolitinib versus basiliximab for steroid-refractory acute graft-versus-host disease: a retrospective study
Acute graft-versus-host disease (aGVHD) remains a major limitation of allogeneic hematopoietic stem cell transplantation; not all patients respond to...
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Understanding and treatment of cutaneous graft-versus-host-disease
The skin is the outermost mechanical barrier where dynamic immune reactions take place and is the most commonly affected site in both acute and...
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The effect of danger-associated molecular patterns on survival in acute graft versus host disease
Danger-associated molecular patterns (DAMPs) are molecules that can initiate and maintain robust inflammatory responses and were investigated in the...
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PET assessment of acute gastrointestinal graft versus host disease
Acute gastrointestinal graft versus host disease (GI-GVHD) is a common complication following allogeneic haematopoietic cell transplantation (HCT),...
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Acute exacerbation of ocular graft-versus-host disease and anterior uveitis after COVID-19 vaccination
BackgroundTo report a case of simultaneous occurrence of acute exacerbation of ocular graft-versus-host disease (GVHD) and anterior uveitis following...
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Low incidence of severe acute and chronic graft-versus-host disease in a long-term retrospective study with ATG Grafalon routine use
Since 2006, combined graft-versus-host disease (GVHD) prophylaxis with ATG Grafalon has been our department’s base of peri-transplant supportive...
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Thrombin receptor activating peptide-6 decreases acute graft-versus-host disease through activating GPR15
G-protein coupled receptor 15 (GPR15) is expressed on T-cells. We previously reported knockout of GPR15 increased acute graft- versus -host disease (G v H...
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Ruxolitinib for the treatment of acute and chronic graft-versus-host disease in children: a systematic review and individual patient data meta-analysis
Steroid-refractory graft-versus-host disease (SR-GvHD) represents a major complication of pediatric allogenic hematopoietic stem cell...
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A convolutional neural network-based model that predicts acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
BackgroundForecasting acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) is highly challenging...
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Ruxolitinib in patients with graft versus host disease (GvHD): findings from a compassionate use program
The ruxolitinib compassionate use (CU) program offered ruxolitinib to patients ≥2 years of age with confirmed steroid-resistant acute or chronic...
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Graft-versus-host disease and impact on relapse in myelofibrosis undergoing hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only curative treatment for myelofibrosis (MF). Relapse occurs in 10–30%...
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Leveraging machine learning for predicting acute graft-versus-host disease grades in allogeneic hematopoietic cell transplantation for T-cell prolymphocytic leukaemia
Orphan diseases, exemplified by T-cell prolymphocytic leukemia, present inherent challenges due to limited data availability and complexities in...
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Extracorporeal photopheresis in acute and chronic steroid‑refractory graft-versus-host disease: an evolving treatment landscape
Patients with steroid-refractory graft-versus-host disease (GvHD) are known to have a poor prognosis and for decades no approved drug has been...
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Immunopathological mechanisms and clinical manifestations of ocular graft-versus-host disease following hematopoietic stem cell transplantation
Graft-versus-host disease is among the most common clinical complications following allogeneic hematopoietic stem cell transplantation. It causes...
