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Saturated fat, the estimated absolute risk and certainty of risk for mortality and major cancer and cardiometabolic outcomes: an overview of systematic reviews
ObjectiveTo assess the impact of reducing saturated fat or fatty foods, or replacing saturated fat with unsaturated fat, carbohydrate or protein, on...
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Interpreting Absolute and Relative Risk Reduction in the Context of Recent Cardiovascular Outcome Trials in Patients with Type 2 Diabetes
Purpose of ReviewThe cardiovascular benefits of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide 1 receptor agonists...
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Absolute and relative GFR and contrast medium dose/GFR ratio: cornerstones when predicting the risk of acute kidney injury
AbstractGlomerular filtration rate (GFR) is considered the best overall index of kidney function in health and disease and its use is recommended to...
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Risk Factors for Breast Cancer-Related Lymphedema, Risk Reduction, and Myths about Precautionary Behaviors
Purpose of ReviewIdentifying and treating long-term complications of cancer treatment, including breast cancer-related lymphedema (BCRL), is...
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A Critical Review of Icosapent Ethyl in Cardiovascular Risk Reduction
Icosapent ethyl (IPE) was the first fish oil product the US Food and Drug Administration (FDA) approved to reduce the risk of atherosclerotic...
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Association of absolute and relative hand grip strength with all-cause mortality among middle-aged and old-aged people
ObjectivesThis study aimed to examine the association of absolute and relative hand grip strength (HGS) with the risk of all-cause mortality among...
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Unexplained Residual Risk In Type 2 Diabetes: How Big Is The Problem?
Purpose of ReviewWhat is new? Cardiovascular disease (CVD) is the leading cause of mortality in type 2 diabetes (T2D) individuals. Of the major risk...
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Comparison of patient demographics and patient-specific risk factors for readmissions following open reduction and internal fixation for acetabular fractures
PurposeAcetabular fractures are highly complex injuries often resulting from high-energy trauma. The gold standard treatment for these injuries has...
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Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count
Clozapine is effective at reducing symptoms of treatment-resistant schizophrenia, but it can also induce several adverse outcomes including...
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Implications of ACC/AHA Versus ESC/EAS LDL-C Recommendations for Residual Risk Reduction in ASCVD: A Simulation Study From DA VINCI
PurposeLow-density lipoprotein cholesterol (LDL-C) recommendations differ between the 2018 American College of Cardiology/American Heart Association...
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Impact of Immunosenescence in Older Kidney Transplant Recipients: Associated Clinical Outcomes and Possible Risk Stratification for Immunosuppression Reduction
The number of older individuals receiving a kidney transplant as replacement therapy has significantly increased in the past decades and this...
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High-risk pooling for mitigating risk selection incentives in health insurance markets with sophisticated risk equalization: an application based on health survey information
BackgroundDespite sophisticated risk equalization, insurers in regulated health insurance markets still face incentives to attract healthy people and...
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Achieving the “Ending the HIV Epidemic in the U.S.” incidence reduction goals among at-risk populations in the South
IntroductionAntiretroviral medication coverage remains sub-optimal in much of the United States, particularly the Sothern region, and Non-Hispanic...
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Potential Predictors of Cardiovascular Risk Improvement in Patients with Hidradenitis Suppurativa Treated with Adalimumab: A Pivotal Study of Factors Associated with Carotid Intima–Media Thickness Reduction
IntroductionHidradenitis suppurativa (HS) has been linked to higher cardiovascular risk (CVR) due to its inflammatory burden. There is little...
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Improving cardiovascular health in patients with an abdominal aortic aneurysm: development of the cardiovascular risk reduction in patients with aneurysms (CRISP) behaviour change intervention
BackgroundAbdominal aortic aneurysm (AAA) is an important cardiovascular health problem. Ultrasound screening is proven to reduce AAA mortality and...
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Benefit of Combination Ezetimibe/Simvastatin Among High-Risk Populations: Lessons from the IMPROVE-IT Trial
Purpose of ReviewThe Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) demonstrated the clinical benefit of the...
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Can absolute arterial phase hyperenhancement improve sensitivity of detection of hepatocellular carcinoma in indeterminate nodules on CT?
ObjectivesTo determine if quantitative assessment of relative (R) and absolute (A) arterial phase hyperenhancement (APHE) and washout (WO) applied to...
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Absolute treatment effects of novel antidiabetic drugs on a composite renal outcome: meta-analysis of digitalized individual patient data
BackgroundAbsolute treatment benefits—expressed as numbers needed to treat—of the glucose lowering and cardiovascular drugs, glucagon-like peptide-1...
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Competing risk analysis of cardiovascular disease risk in breast cancer patients receiving a radiation boost
BackgroundThoracic radiotherapy may damage the myocardium and arteries, increasing cardiovascular disease (CVD) risk. Women with a high local breast...
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Anticoagulant use in older persons at risk for falls: therapeutic dilemmas—a clinical review
PurposeThe aim of this clinical narrative review was to summarise the existing knowledge on the use of anticoagulants and potential adverse events in...
