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Autoregulation: mediators and renin–angiotensin system in diseases and treatments
BackgroundHemodynamic regulation is a substantial part of the physiological integrity of the human body. It is based on the delivery of proper blood...
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Ang-(1-7) treatment attenuates lipopolysaccharide-induced early pulmonary fibrosis
Early pulmonary fibrosis is the leading cause of poor prognosis in patients with acute respiratory distress syndrome (ARDS). However, whether the...
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Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice—
Angiotensin converting enzyme 2 (ACE2) functions as an enzyme that produces angiotensin 1-7 (A1-7) from angiotensin II (AII) in the renin-angiotensin...
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Emerging Therapeutic Targets for Portal Hypertension
Purpose of ReviewPortal hypertension is responsible of the main complications of cirrhosis, which carries a high mortality. Recent treatments have...
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2020 update on the renin–angiotensin–aldosterone system in pediatric kidney disease and its interactions with coronavirus
The last decade was crucial for our understanding of the renin–angiotensin–aldosterone system (RAAS) as a two-axis, counter-regulatory system,...
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125I-Angiotensin 1–7 binds to a different site than angiotensin 1–7 in tissue membrane preparations
PurposeTo study the receptor for Angiotensin (Ang) 1–7 using a radioligand ( 125 I-Ang 1–7)-binding assay. For more than a decade, Mas has been viewed...
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Emerging Therapy in Hypertension
Purpose of the ReviewPharmacology remains the mainstay of treatment for hypertension across the globe. In what may seem like a well-trodden field,...
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Counter-regulatory renin–angiotensin system in cardiovascular disease
The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of...
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Novel Targets and Drug Development in Portal Hypertension
Purpose of the ReviewThis review aims to introduce animal models of portal hypertension in which targets and drugs can be tested and presents current...
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New Molecules for Treating Resistant Hypertension: a Clinical Perspective
Purpose of ReviewTo review the findings of trials evaluating pharmacological treatment approaches for hypertension in general, and resistant...
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Angiotensin-(1–7) and Alamandine on Experimental Models of Hypertension and Atherosclerosis
Purpose of ReviewThe purpose of this review was to summarize the current knowledge on the role of angiotensin-(1–7) [Ang-(1–7)] and alamandine in...
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Dimerization of AT2 and Mas Receptors in Control of Blood Pressure
Purpose of ReviewAngiotensin type 2 receptor (AT 2 R) and receptor Mas (MasR) are part of the “protective arm” of the renin angiotensin system. Gene...
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The renin–angiotensin system in cardiovascular autonomic control: recent developments and clinical implications
Complex and bidirectional interactions between the renin–angiotensin system (RAS) and autonomic nervous system have been well established for...
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Novel Medical Treatments for Hypertension and Related Comorbidities
Purpose of ReviewThe purpose of this review is to summarize the most recent data available on advances in development of novel medical treatments for...
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The role of ACE2, angiotensin-(1–7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction
BackgroundPlasma and urine levels of the potent vasodilator Ang-(1–7) are elevated in mid and late pregnancy and are correlated with elevated...
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Novelties in the pathophysiology and management of portal hypertension: new treatments on the horizon
Portal hypertension (PH) is responsible for the most severe complications of cirrhosis and leading cause of death and liver transplantation. The...
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Possible Treatment Strategies for Portal Hypertension in Liver Cirrhosis
Purpose of the ReviewChronic liver injury leading to fibrosis and complicated by portal hypertension is an emerging burden for health systems...
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Angiotensin-Converting Enzyme 2 as a Therapeutic Target for Heart Failure
The renin-angiotensin system (RAS) plays a major role in the pathophysiology of cardiovascular disorders. Angiotensin II (Ang-II), the final product...
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Current perspectives in genetic cardiovascular disorders: from basic to clinical aspects
We summarize recent advances in the clinical genetics of hypercholesterolemia, hypertrophic cardiomyopathy (HCM), and lethal arrhythmia, all of which...
