Search
Search Results
-
Limiting systemic endocrine overtreatment in postmenopausal breast cancer patients with an ultralow classification of the 70-gene signature
PurposeGuidelines recommend endocrine treatment for estrogen receptor-positive (ER+) breast cancers for up to 10 years. Earlier data suggest that the...
-
The 70-gene signature test as a prognostic and predictive biomarker in patients with invasive lobular breast cancer
PurposeGenomic expression assays provide prognostic information and guide adjuvant chemotherapy decisions for patients with estrogen receptor...
-
Combining method of detection and 70-gene signature for enhanced prognostication of breast cancer
PurposeStudies have shown that screen detection by national screening programs is independently associated with better prognosis of breast cancer....
-
Age-Independent Preoperative Chemosensitivity and 5-Year Outcome Determined by Combined 70- and 80-Gene Signature in a Prospective Trial in Early-Stage Breast Cancer
BackgroundThe Neoadjuvant Breast Symphony Trial (NBRST) demonstrated the 70-gene risk of distant recurrence signature, MammaPrint, and the 80-gene...
-
Validation of a methylation-based signature for subventricular zone involvement in glioblastoma
PurposeGlioblastomas (GBM) with subventricular zone (SVZ) contact have previously been associated with a specific epigenetic fingerprint. We aim to...
-
PTK2-associated gene signature could predict the prognosis of IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have...
-
A novel pyroptosis-related gene signature exhibits distinct immune cells infiltration landscape in Wilms’ tumor
BackgroundWilms’ tumor (WT) is the most common renal tumor in childhood. Pyroptosis, a type of inflammation-characterized and immune-related...
-
Novel prognostic gene signature for pancreatic ductal adenocarcinoma based on hypoxia
BackgroundCurrently, there is lack of marker to accurately assess the prognosis of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC)....
-
A novel 5-gene prognostic signature to improve risk stratification of cytogenetically normal acute myeloid leukemia
PurposePrognostic prediction is a challenging task in cytogenetically normal acute myeloid leukemia (CN-AML) patients. In this study, we aimed at...
-
A Novel Eight-Gene Signature for Lipid Metabolism Predicts the Progression of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma
Recently, studies on the mechanisms underlying lipid metabolic reprogramming in cancer have increased. However, its significance in cervical cancer...
-
A Novel pyroptosis-related signature for predicting prognosis and evaluating tumor immune microenvironment in ovarian cancer
Ovarian cancer (OV) is the most fatal gynecological malignant tumor worldwide, with high recurrence rates and great heterogeneity. Pyroptosis is a...
-
RUNX3 pathway signature predicts clinical benefits of immune checkpoint inhibition plus tyrosine kinase inhibition in advanced renal cell carcinoma
BackgroundCheckpoint inhibitor immunotherapy plus tyrosine kinase inhibitor (IO/TKI) have been recently recommended as standard first-line therapy...
-
Utility of UV Signature Mutations in the Diagnostic Assessment of Metastatic Head and Neck Carcinomas of Unknown Primary
BackgroundMetastatic carcinoma of unknown primary origin to the head and neck lymph nodes (HNCUP) engenders unique diagnostic considerations. In many...
-
Identification of a gene expression signature associated with brain metastasis in colorectal cancer
PurposeBrain metastasis (BM) in colorectal cancer (CRC) is a rare event with poor prognosis. Apart from (K)RAS status and lung and bone metastasis no...
-
Characterization of stem cell subtypes and prognostic signature in hepatocellular carcinoma
BackgroundCancer stem cells (CSCs) were linked to cancer aggressiveness and poor prognosis in patients with hepatocellular carcinoma (HCC).
...
-
Identification of immune-related signature with prognosis in children with stage 4 and 4S neuroblastoma
ObjectiveSpontaneous regression of tumors is an attractive phenomenon that most commonly occurs in stage 4S neuroblastoma (NB). However, the...
-
A novel endoplasmic reticulum stress-related lncRNA signature for prognosis prediction and immune response evaluation in Stomach adenocarcinoma
backgroundStomach adenocarcinoma (STAD) is a significant contributor to cancer-related mortality worldwide. Although previous research has identified...
-
T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia
Background and ObjectiveAcute myeloid leukemia (AML) is an aggressive, heterogenous hematopoetic malignancies with poor long-term prognosis. T-cell...
