Search
Search Results
-
Neonatal 6-hydroxydopamine lesioning of rats and dopaminergic neurotoxicity: proposed animal model of Parkinson’s disease
The neurotoxin 6-hydroxydopamine (6-OHDA), following pretreatment with the norepinephrine transport inhibitor desipramine, selectively destroys...
-
Thymol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson’s disease via inhibiting oxidative stress
BackgroundParkinson’s disease (PD) is a multifactorial movement disorder with the progressive degeneration of the nigrostriatal system that impairs...
-
Preclinical evaluation of [18F]FP-CIT, the radiotracer targeting dopamine transporter for diagnosing Parkinson’s disease: pharmacokinetic and efficacy analysis
BackgroundN -(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine...
-
Generation of human A9 dopaminergic pacemakers from induced pluripotent stem cells
The degeneration of nigral (A9) dopaminergic (DA) neurons causes motor symptoms in Parkinson’s disease (PD). We use small-molecule compounds to...
-
Peripheral benzodiazepine receptor/18 kDa translocator protein positron emission tomography imaging in a rat model of acute brain injury
ObjectiveThe activation of microglia in various brain pathologies is accompanied by an increase in the expression of peripheral benzodiazepine...
-
Neuroprotective effects of Shende’an tablet in the Parkinson’s disease model
BackgroundShende’an tablet (SDA) is a newly capsuled Chinese herbal formula derived from the Chinese traditional medicine Zhengan **feng Decoction...
-
Neuroprotective effect of regular swimming exercise on calretinin-positive striatal neurons of Parkinsonian rats
In Parkinson’s disease (PD), physical therapy is one of the mainstays of supportive treatment modalities. This study focused on the neuroprotective...
-
6-Hydroxydopamine: a far from simple neurotoxin
6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been...
-
Fear Memory in Experimental Models of Parkinson’s Disease
AbstractParkinson’s disease (PD) is a neurodegenerative disease, the main predisposing factor of which is aging. Today, the majority of people...
-
Blood oxygen regulation via P2Y12R expressed in the carotid body
BackgroundPeripheral blood oxygen monitoring via chemoreceptors in the carotid body (CB) is an integral function of the autonomic cardiorespiratory...
-
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing
Traumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism remains largely unknown. Accumulating evidence indicates that...
-
Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine
The catecholamine neuromodulators dopamine and norepinephrine are implicated in motor function, motivation, and cognition. Although roles for...
-
From lab bench to hope: a review of gene therapies in clinical trials for Parkinson’s disease and challenges
Parkinson's disease (PD) is a chronic neurological disorder that is identified by a characteristic combination of symptoms such as bradykinesia,...
-
Unraveling the role of glial cell line–derived neurotrophic factor in the treatment of Parkinson’s disease
Parkinson’s disease is the second most common neurodegenerative condition with its prevalence projected to 8.9 million individuals globally in the...
-
The effects of regular swimming exercise and melatonin on the neurons localized in the striatum of hemiparkinsonian rats
Parkinson’s disease is a progressive neurodegenerative movement disorder. We aimed to investigate the effects of regular swimming exercise and...
-
From Bench to Bedside: Unveiling the Effects of Phloroglucinol as a Promising Neuroprotective Agent in the Battle Against Neurodegenerative Disorders
Purpose of ReviewPhloroglucinol (PG) is a potent secondary metabolite found in various organisms, with extensive applications in medicine since its...
-
The specific NQO2 inhibitor, S29434, only marginally improves the survival of dopamine neurons in MPTP-intoxicated mice
Over the years, evidence has accumulated on a possible contributive role of the cytosolic quinone reductase NQO2 in models of dopamine neuron...
-
The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson’s disease
Parkinson’s disease (PD) is a chronic, progressive, neurodegenerative disease. The predominant pathology of PD is the loss of dopaminergic cells in...
-
Dysphagia in Parkinson Disease: Part II—Current Treatment Options and Insights from Animal Research
Purpose of ReviewDysphagia is highly prevalent in Parkinson disease (PD) but is not typically identified nor treated until later in the disease...
-
Neuroprotective compounds from marine invertebrates
BackgroundNeuroinflammation is a key pathological feature of a wide variety of neurological disorders, including Parkinson’s, multiple sclerosis,...
