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New insights in the genetic variant spectrum of SLC34A2 in pulmonary alveolar microlithiasis; a systematic review
Pulmonary alveolar microlithiasis (PAM) is a rare autosomal recessive lung disease caused by variants in the SLC34A2 gene encoding the...
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Evaluating pathogenicity of SLC34A3-Ser192Leu, a frequent European missense variant in disorders of renal phosphate wasting
Loss-of-function mutations of SLC34A3 represent an established cause of a distinct renal phosphate wasting disorder termed hereditary...
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Inherited Arterial Calcification Syndromes: Etiologies and Treatment Concepts
Purpose of ReviewWe give an update on the etiology and potential treatment options of rare inherited monogenic disorders associated with arterial...
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Loss of function of NaPiIIa causes nephrocalcinosis and possibly kidney insufficiency
BackgroundInherited metabolic disorders associated with nephrocalcinosis are rare conditions. The aim of this study was to identify the genetic cause...
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Exercise training restores the cardiac microRNA-1 and −214 levels regulating Ca2+ handling after myocardial infarction
BackgroundImpaired cardiomyocyte contractility and calcium handling are hallmarks of left ventricular contractile dysfunction. Exercise training has...
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Primary familial brain calcification: update on molecular genetics
Primary familial brain calcification is a neuropsychiatric disorder with calcium deposits in the brain, especially in basal ganglia, cerebellum and...
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Phosphate enhances reactive oxygen species production and suppresses osteoblastic differentiation
Phosphate has been shown to work as a signaling molecule in several cells including endothelial cells and chondrocytes. However, it is largely...
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Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis
Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion and metastasis. ATX converts extracellular lysophosphatidylcholine (LPC)...
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Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level
Protein kinase CK2 is an ubiquitous and constitutively active kinase, which phosphorylates many cellular proteins and is implicated in the regulation...
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Parathormone sensitivity and responses to protein kinases in subclones of opossum kidney cells
Parathyroid hormone (PTH) inhibits sodium-dependent phosphate (Na + -Pi) transport in the renal proximal tubule and opossum kidney (OK) cells by...
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Ontogeny of renal phosphate transport and the process of growth
The kidneys of infants and children reabsorb a high fraction of the filtered phosphate (Pi), as appropriate to the needs of a growing organism. This...
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Evidence for a role of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in thapsigargin and Bcl-2 induced changes in
Xenopus laevis oocyte maturationThapsigargin (Tg), a selective inhibitor of sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase (SERCA), causes depletion of intracellular Ca 2+ stores,...
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Fencamfamine modulates sodium, potassium-ATPase through cyclic AMP and cyclic AMP-dependent protein kinase in rat striatum
Dopamine (DA) and fencamfamine (FCF) modulatory action on Na,K-ATPase and Mg-ATPase activity were evaluated in rat striatum. DA and FCF induced a...
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Age dependence of tolerance to anoxia and changes in cytosolic calcium in rabbit renal proximal tubules
Calcium(Ca 2+ )-dependent processes mediate, in part, anoxic cell injury. These may account for the difference in sensitivity to anoxia between certain...
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Noncollagenous matrix protein-enhanced mineral deposition in osteoblast-like cell culture
Osteoblasts responsible for bone formation have been reported to synthesize and secrete type I collagen and other matrix proteins in the process of...