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Neurofibromatose Typ 1
BackgroundNeurofibromatosis type 1 (NF1) is a tumor predisposition syndrome and is one of the most common genetic diseases. It is therefore a...
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Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Current management of chronic kidney disease (CKD) in type 1 diabetes centres on glycaemic control, renin–angiotensin system inhibition and...
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Urinary dipeptidase 1 and trefoil factor 1 are promising biomarkers for early diagnosis of colorectal cancer
BackgroundCurrently utilized serum tumor markers and fecal immunochemical tests do not have sufficient diagnostic power for colorectal cancer (CRC)...
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Association of TNF-α, IGF-1, and IGFBP-1 levels with the severity of osteopenia in mice with nonalcoholic fatty liver disease
BackgroundsNonalcoholic fatty liver disease (NAFLD) exhibits a close association with osteoporosis. This work aims to assess the potential effects of...
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New diagnostic criteria (2023) for slowly progressive type 1 diabetes (SPIDDM): Report from Committee on Type 1 Diabetes in Japan Diabetes Society (English version)
The diagnostic criteria for slowly progressive type 1 diabetes (slowly progressive insulin-dependent diabetes mellitus; SPIDDM) have been revised by...
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Can signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) be used as an indicator of endothelial dysfunction in acromegaly patients?
PurposeAcromegaly is closely related to increased oxidative stress and endothelial dysfunction (ED). This study aimed to evaluate, for the first time...
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Glucagon-Like Peptide 1 (GLP-1) Receptor Variants and Glycemic Response to Liraglutide: A Pharmacogenetics Study in Iranian People with Type 2 Diabetes Mellitus
IntroductionPharmacogenetics studies suggest that genetic variants have a possible influence on the inter-individual differences in therapeutic...
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Kardiovaskuläre Protektion durch Rezeptoragonisten des glukagonähnlichen Peptids 1
The incidence of type 2 diabetes mellitus is increasing worldwide with serious cardiovascular consequences. Glucagon-like peptide 1 (GLP-1) is an...
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Survival benefits of postoperative radiotherapy in patients with cT1 − 2N1M0 breast cancer after neoadjuvant chemotherapy: a SEER-based population study
BackgroundWhether patients with cT 1 − 2 N 1 M 0 breast cancer can benefit from postoperative radiotherapy (RT) after receiving neoadjuvant chemotherapy...
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The relationship between islet autoantibody status and the genetic risk of type 1 diabetes in adult-onset type 1 diabetes
Aims/hypothesisThe reason for the observed lower rate of islet autoantibody positivity in clinician-diagnosed adult-onset vs childhood-onset type 1...
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A methodological review of randomised n-of-1 trials
Backgroundn-of-1 trials are a type of crossover trial designed to optimise the evaluation of health technologies in individual patients. This trial...
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Efficacy and safety of anti-PD-1/PD-L1-based dual immunotherapies versus PD-1/PD-L1 inhibitor alone in patients with advanced solid tumor: a systematic review and meta-analysis
IntroductionNumerous randomized controlled trials (RCTs) have investigated PD-1/PD-L1 inhibitor-based combination therapies. The debate surrounding...
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Beyond glycemia: Comparing tirzepatide to GLP-1 analogues
Glucagon-like peptide-1 receptor analogs (GLP-1 RAs) have been an innovative and instrumental drug class in the management of both type 2 diabetes...
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Alpha-1-Antitrypsin-Mangel – neue therapeutische Optionen bei hepatischer Manifestation
Alpha‑1 antitrypsin (AAT) is one of the most important protease inhibitors. It is primarily synthesized in the liver and released into the...
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Metabolic profiling of galectin-1 and galectin-3: a cross-sectional, multi-omics, association study
ObjectivesExperimental studies indicate a role for galectin-1 and galectin-3 in metabolic disease, but clinical evidence from larger populations is...
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Lumasiran: A Review in Primary Hyperoxaluria Type 1
Lumasiran (Oxlumo ® ), a first-in-class synthetic, double-stranded, ribonucleic acid (RNA) interference molecule targeting glycolate oxidase through...
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High plasma concentrations of vanin-1 in patients with coronary artery disease
Vanin-1 is a pantetheinase that hydrolyzes pantetheine to pantothenic acid and cysteamine. Vanin-1 has become recognized to be associated with...
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An ecological resilience model for adolescents with type 1 diabetes: a cross-sectional study
BackgroundHighly resilient adolescents with type 1 diabetes have been proved to achieve within-target glycemic outcomes and experience high quality...
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1 plus 1 is more than 2: mental health problems, financial difficulties, and social exclusion in a cross-sectional study of 28,047 general-population adults
BackgroundMental health problems and financial difficulties each increase the risk of social exclusion. However, few large studies representing a...
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Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women
BackgroundPolycystic ovary syndrome (PCOS) presents clinical symptoms of menstrual abnormalities, excessive hair growth (hirsutism), scalp hair loss,...
