Search
Search Results
-
WNT/β-catenin regulatory roles on PD-(L)1 and immunotherapy responses
Dysregulation of WNT/β-catenin is a hallmark of many cancer types and a key mediator of metastasis in solid tumors. Overactive β-catenin signaling...
-
EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors
β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the...
-
Urolithin C alleviates pancreatic β-cell dysfunction in type 1 diabetes by activating Nrf2 signaling
AimsType 1 diabetes (T1D) is an autoimmune disorder that destroys insulin-generating pancreatic β-cells. Preserving pancreatic β-cell function is...
-
The correlation between serum 1, 5-anhydroglucitol and β-cell function in Chinese adults with different glucose metabolism statuses
ObjectiveSerum 1, 5-AG is a glycaemic marker reflecting control and fluctuations of short-term glucose. To reveal the relationship between 1, 5-AG...
-
Curcumin Interferes with TGF- β 1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation
ObjectiveTo explore the molecular mechanism by which curcumin affects renal interstitial fibrosis (RIF) progression by regulating ADAM...
-
Synergistic efficacy of simultaneous anti-TGF-β/VEGF bispecific antibody and PD-1 blockade in cancer therapy
BackgroundRecently, therapeutic antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1) have exerted potent anticancer effect in a...
-
Parathyroid hormone (1–34) retards the lumbar facet joint degeneration and activates Wnt/β-catenin signaling pathway in ovariectomized rats
PurposeFacet joint degeneration (FJD) is a major cause of low back pain. Parathyroid hormone (PTH) (1–34) is commonly used to treat osteoporosis....
-
Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis
BackgroundHuman T-cell lymphotropic virus type 1 (HTLV-1), also denominated Human T-cell leukemia virus-1, induces immune activation and secretion of...
-
β-adrenergic modulation of IL-6/gp130 and SOCS-1 in multiple myeloma: therapeutic strategy for stress induced-inflammatory response
PurposeMultiple Myeloma (MM) is considered an incurable, biologically heterogeneous disease of the plasma cells. The clinical data on the association...
-
Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?
A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic β-cells but not neighbouring α-cells, even though both...
-
Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of p21
Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and cancer recurrence. CSCs growth and progression are regulated...
-
Involvement of Interleukin-1 β/Insulin-Like Growth Factor 1 in Ameliorating Effects of Electroacupuncture on Myocardial Fibrosis Induced by Essential Hypertension
ObjectiveTo investigate the effect of electroacupuncture (EA) at Neiguan (PC 6) on myocardial fibrosis in spontaneously hypertensive rats (SHRs), and...
-
Association of serum transforming growth factor β1 with left ventricular hypertrophy in children with primary hypertension
The current study was designed to assess the association of serum transforming growth factor β 1 (TGF-β 1 ) with left ventricular hypertrophy (LVH) in...
-
Specificity protein 1/3 regulate T-cell acute lymphoblastic leukemia cell proliferation and apoptosis through β-catenin by acting as targets of miR-495-3p
T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic heterogeneous disease. This study explored the mechanism of specificity protein 1/3...
-
Association between osteocalcin and residual β-cell function in children and adolescents newly diagnosed with type 1 diabetes: a pivotal study
PurposeThis pivotal study aimed to evaluate circulating levels of bone remodeling markers in children and adolescents at the onset of type 1 diabetes...
-
Anlotinib Attenuates Liver Fibrosis by Regulating the Transforming Growth Factor β1/Smad3 Signaling Pathway
BackgroundHepatic stellate cell hyperactivation is a central link in liver fibrosis development, transforming growth factor β 1 (TGF- β 1) is a key...
-
P1NP and β-CTX-1 Responses to a Prolonged, Continuous Running Bout in Young Healthy Adult Males: A Systematic Review with Individual Participant Data Meta-analysis
BackgroundCirculating biomarkers of bone formation and resorption are widely used in exercise metabolism research, but their responses to exercise...
-
Value of 3D ultrasound flow imaging combined with serum AFP, β-hCG, sFlt-1 and CK in the diagnosis of placenta accreta
PurposeTo analyze the diagnostic value of placenta three-dimensional (3D) energy blood flow parameters combined with maternal serum AFP, β-hCG,...
-
Cai’s herbal tea enhances mitochondrial autophagy of type 1 diabetic mellitus β cells through the AMPK/mTOR pathway and alleviates inflammatory response
BackgroundThis study investigates the therapeutic mechanisms of Cai’s Herbal Tea in Type 1 Diabetes Mellitus (T1DM) mice, focusing on its effects on...
