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Exploring CCL11 in breast cancer: unraveling its anticancer potential and immune modulatory effects involving the Akt-S6 signaling
BackgroundCCL11, a chemokine known for recruiting immune cells to the tumor microenvironment (TME), has an unclear role in the context of its...
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BAG3 as a novel prognostic biomarker in kidney renal clear cell carcinoma correlating with immune infiltrates
PurposeBCL-2-associated athanogene 3 (BAG3) is an anti-apoptotic protein that plays an essential role in the onset and progression of multiple cancer...
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Associations between immune cell phenotypes and lung cancer subtypes: insights from mendelian randomization analysis
IntroductionLung cancer is a common malignant tumor, and different types of immune cells may have different effects on the occurrence and development...
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Genetic alterations shape innate immune cells to foster immunosuppression and cancer immunotherapy resistance
Cancer immunotherapy, particularly immune checkpoint inhibitors, has opened a new avenue for cancer treatment following the durable clinical...
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Bioinformatics-based screening and analysis of the key genes involved in the influence of antiangiogenesis on myeloid-derived suppressor cells and their effects on the immune microenvironment
This study aimed to screen differentially expressed genes (DEGs) involved in the influence of antiangiogenic therapy on myeloid-derived suppressor...
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Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer
PurposeCD226 (DNAM-1) is an activating receptor mainly expressed in CD8 + and NK cells. CD226 deficiency and blockade have been shown to impair tumor...
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Effects of tumor-infiltrating CD8+ T cells, PD1/PD-L1 axis, and expression patterns of HLA class I on the prognosis of patients with malignant pleural mesothelioma who underwent extra-pleural pneumonectomy
Programmed cell death protein-1 (PD1), PD1 ligand 1 (PD-L1), and human leukocyte antigen (HLA) class I molecule play pivotal roles in T cell-induced...
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The S100 family is a prognostic biomarker and correlated with immune cell infiltration in pan-cancer
BackgroundThe S100 protein family is a group of small molecular EF-hand calcium-binding proteins that play critical roles in various biological...
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Higher inflammatory response in hepatocellular carcinoma is associated with immune cell infiltration and a better outcome
Background and aimsHepatocellular carcinoma (HCC) often develops from chronic liver inflammation. Inflammation within a tumor can either promote...
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Diagnostic Value of GDF10 for the Tumorigenesis and Immune Infiltration in Lung Squamous Cell Carcinoma
ObjectiveLung squamous cell carcinoma (LUSC) is associated with a low survival rate. Evidence suggests that bone morphogenetic proteins (BMPs) and...
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Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma
Lymph node metastases are strongly associated with unfavorable prognosis in papillary thyroid carcinoma (PTC) patients. However, there are few...
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High-dimensional map** of human CEACAM1 expression on immune cells and association with melanoma drug resistance
BackgroundHuman carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) is an inhibitory cell surface protein that functions through homophilic...
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CD2-negative lymphoma-associated T-cells: a potential mechanism of immune-evasion in diffuse large B-cell lymphoma
CD2 is a costimulatory protein expressed in all mature T/NK-cells, in particular memory T-cells. CD58 (or LFA-3) is the receptor for CD2 and is...
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Tumor microenvironment in triple-negative breast cancer: the correlation of tumor-associated macrophages and tumor-infiltrating lymphocytes
PurposeImmune cells such as cytotoxic T cells, helper T cells, B cells or tumor-associated macrophages (TAMs) contribute to the anti-tumor response...
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A modified immune cell infiltration score achieves ideal stratification for CD8+ T cell efficacy and immunotherapy benefit in hepatocellular carcinoma
Immunotherapy, which aims to enhance the function of T cells, has emerged as a novel therapeutic approach for hepatocellular carcinoma (HCC)....
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Prognostic impact of an integrative analysis of [18F]FDG PET parameters and infiltrating immune cell scores in lung adenocarcinoma
BackgroundHigh levels of 18 F-fluorodeoxyglucose ( 18 F-FDG) tumor uptake are associated with worse prognosis in patients with non-small cell lung...
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Distribution of tumor-infiltrating-T-lymphocytes and possible tumor-escape mechanisms avoiding immune cell attack in locally advanced adenocarcinomas of the esophagus
IntroductionThe inflammatory microenvironment has emerged as one of the focuses of cancer research. Little is known about the immune environment in...
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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic...
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TREM-1 as a potential prognostic biomarker associated with immune infiltration in clear cell renal cell carcinoma
BackgroundThe tumor immune microenvironment plays a crucial role in the efficacy of various therapeutics. However, their correlation is not yet...
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Comprehensive analysis of anoikis-related genes in prognosis and immune infiltration of gastric cancer based on bulk and single-cell RNA sequencing data
BackgroundAccumulating evidence suggests that anoikis resistance is a key process in cancer cell metastasis, making it an attractive therapeutic...
