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Clinical and diagnostic utility of genomic sequencing for children referred to a Kidney Genomics Clinic with microscopic haematuria
BackgroundMicroscopic haematuria in children is associated with the risk of progression to chronic kidney disease. Genetic disease is an important...
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Use of the VerifyNow point of care assay to assess the pharmacodynamic effects of loading and maintenance dose regimens of prasugrel and ticagrelor
Prasugrel and ticagrelor are potent oral platelet P2Y 12 inhibitors and are recommended over clopidogrel in patients with acute coronary syndrome...
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Development and validation of multiplex real-time PCR for simultaneous detection of six bacterial pathogens causing lower respiratory tract infections and antimicrobial resistance genes
BackgroundKlebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa , Escherichia coli, Streptococcus pneumoniae and Staphylococcus aureus ...
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Artificial intelligent tools: evidence-map** on the perceived positive effects on patient-care and confidentiality
BackgroundGlobally, healthcare systems have always contended with well-known and seemingly intractable challenges like safety, quality, efficient and...
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Acceptability and feasibility of testing for HIV infection at birth and linkage to care in rural and urban Zambia: a cross-sectional study
BackgroundEarly infant diagnosis is important for timely identification of HIV-infected infants and linkage to care. Testing at birth has been...
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Optimizing the nucleic acid screening strategy to mitigate regional outbreaks of SARS-CoV-2 Omicron variant in China: a modeling study
BackgroundThe Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads rapidly and insidiously. Coronavirus disease...
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Improved Utilization of Serial Testing Without Increased Admissions after Implementation of High-Sensitivity Troponin I: a Controlled Retrospective Cohort Study
BackgroundGuidelines recommend high-sensitivity cardiac troponin (hs-cTn) for diagnosis of myocardial infarction. Use of hs-cTn is increasing across...
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Risk factors for diagnosis and treatment delay among patients with multidrug-resistant tuberculosis in Hunan Province, China
BackgroundMultidrug-resistant tuberculosis (MDR-TB) is a global health threat associated with high morbidity and mortality rates. Diagnosis and...
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Daytime, evening, and overnight: the 24-h radiology cycle and impact on interpretative accuracy
PurposeTo assess the influence of time of day when a study is interpreted on discrepancy rates for common and advanced studies performed in the acute...
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Gastrointestinal Endoscopy-Associated Infections: Update on an Emerging Issue
Over 17.7 million gastrointestinal (GI) endoscopic procedures are performed annually, contributing to 68% of all endoscopic procedures in the United...
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Assessing the impact of trained Radiologist Assistants in a busy emergency teleradiology practice: a comprehensive evaluation
PurposeThis study aims to study the feasibility and usefulness of trained Radiologist Assistants in a busy emergency teleradiology practice.
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Task shifting for point-of-care early infant diagnosis: a comparison of the quality of testing between nurses and laboratory personnel in Zimbabwe
BackgroundTo decentralize point-of-care early infant diagnosis (POC EID), task shifting to cadres such as nurses is important. However, this should...
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Hematologic Parameters of Acute Dengue Fever Versus Other Febrile Illnesses in Ambulatory Returned Travelers
Purpose of ReviewPoint-of-care dengue diagnostics are unavailable in most settings; thus, diagnosis is clinical until more definitive microbiological...
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Rapid and highly sensitive approach for multiplexed somatic fusion detection
Somatic gene translocations are key to making an accurate diagnosis in many cancers including many pediatric sarcomas. Currently available molecular...
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Assessment of Patient Satisfaction with On-Site Point-of-Care Hemoglobin A1c Testing: An Observational Study
IntroductionPoor glycemic control is a serious challenge in successful diabetes management. Given the low adherence and compliance with HbA1c testing...
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Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection
AbstractCytomegalovirus is the most common cause of congenital infectious disease and the leading nongenetic etiology of sensorineural hearing loss....
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Nanopore-Based Metagenomic Sequencing in Respiratory Tract Infection: A Develo** Diagnostic Platform
Respiratory tract infection (RTI) remains a significant cause of morbidity and mortality across the globe. The optimal management of RTI relies upon...
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The impact of COVID-19 on myocardial infarctions, strokes and out-of-hospital cardiopulmonary arrests: an observational retrospective study on time-sensitive disorders in the Friuli Venezia Giulia region (Italy)
The COVID-19 global pandemic has changed considerably the way time-sensitive disorders are treated. Home isolation, people’s fear of contracting the...
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A Lightweight and Robust Framework for Circulating Genetically Abnormal Cells (CACs) Identification Using 4-Color Fluorescence In Situ Hybridization (FISH) Image and Deep Refined Learning
Circulating genetically abnormal cells (CACs) constitute an important biomarker for cancer diagnosis and prognosis. This biomarker offers high...
