Search
Search Results
-
The role of Pcdh10 in neurological disease and cancer
BackgroundProtocadherin 10 (PCDH 10), a member of the superfamily of protocadherins, is a Ca2 + -dependent homophilic cell-cell adhesion molecule...
-
Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts
Cardiac fibrosis is closely associated with multiple heart diseases, which are a prominent health issue in the global world. Neurohormones and...
-
Single-cell RNA sequencing to identify cellular heterogeneity and targets in cardiovascular diseases: from bench to bedside
The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-cell RNA sequencing (scRNA-seq) has enabled the profiling of...
-
Genotype–phenotype relationship and comparison between eastern and western patients with osteogenesis imperfecta
PurposeTo evaluate the genotypic and phenotypic relationship in a large cohort of OI patients and to compare the differences between eastern and...
-
Pleiotropic effects of cell competition between normal and transformed cells in mammalian cancers
PurposeIn the course of tumor progression, cancer clones interact with host normal cells, and these interactions make them under selection pressure...
-
Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis
BackgroundCircular RNAs have shown important regulatory roles in cardiovascular diseases, containing atherosclerosis (AS). We intended to explore the...
-
Recombinant human endostatin as a potential anti-angiogenic agent: therapeutic perspective and current status
Angiogenesis is the physiological process that results in the formation of new blood vessels develop from pre-existing vasculature and plays a...
-
Protein glycosylation in cardiovascular health and disease
Protein glycosylation, which involves the attachment of carbohydrates to proteins, is one of the most abundant protein co-translational and...
-
Astrocytes in the adult dentate gyrus—balance between adult and developmental tasks
Astrocytes, a major glial cell type in the brain, are indispensable for the integration, maintenance and survival of neurons during development and...
-
ISSLS Prize in Basic science 2019: Physical activity attenuates fibrotic alterations to the multifidus muscle associated with intervertebral disc degeneration
PurposeChronic low back pain causes structural remodelling and inflammation in the multifidus muscle. Collagen expression is increased in the...
-
Single-cell sequencing: a promising approach for uncovering the mechanisms of tumor metastasis
Single-cell sequencing (SCS) is an emerging high-throughput technology that can be used to study the genomics, transcriptomics, and epigenetics at a...
-
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This is mostly due to highly...
-
Dynamic tumor microenvironment, molecular heterogeneity, and distinct immunologic portrait of triple-negative breast cancer: an impact on classification and treatment approaches
Heterogeneity of the tumor microenvironment (TME) and the lack of a definite targetable receptor in triple-negative breast cancer (TNBC) has carved a...
-
Supporting strategic health purchasing: a case study of annual health budgets from general tax revenue and social health insurance in Abia state, Nigeria
BackgroundTracking general trends in strategic purchasing of health financing mechanisms will highlight where country demands may exist for technical...
-
Identification of the potential biological target molecules related to primary open-angle glaucoma
BackgroundTo identify the potential biological target molecules and the corresponding interaction networks in primary open-angle glaucoma (POAG)...
-
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
Opioid use disorder (OUD) among pregnant women has become an epidemic in the United States. Pharmacological interventions for maternal OUD most...
-
Novel partners of USP6 gene in a spectrum of bone and soft tissue lesions
Nodular fasciitis, primary aneurysmal bone cyst, myositis ossificans, and their related lesions are benign tumors that share common histological...
-
Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy
Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells...
-
Genetic-driven biomarkers for liver fibrosis through bioinformatic approach
BackgroundLiver fibrosis is a widespread chronic liver ailment linked to substantial mortality and limited therapeutic options. An in-depth...
-
