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A study protocol for a randomised controlled trial to evaluate the effectiveness of a dog-facilitated physical activity minimal intervention on young children’s physical activity, health and development: the PLAYCE PAWS trial
BackgroundPet ownership brings many health benefits to individuals. In children developmental benefits can extend to improved self-esteem, better...
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Cognitive household labor: gender disparities and consequences for maternal mental health and wellbeing
PurposeAlthough the division of unpaid household labor has been studied as a driver of global gender inequity, the cognitive dimension of household...
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The development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials
BackgroundA failure of clinical trials to retain participants can influence the trial findings and significantly impact the potential of the trial to...
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Factors Associated with Weight Loss Maintenance and Weight Regain Among African American and White Adults Initially Successful at Weight Loss
BackgroundProviding ongoing treatment through extended care programs can improve weight loss maintenance (WLM), but the effectiveness of these...
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Development of a co-designed behaviour change intervention aimed at healthcare professionals recruiting to clinical trials in maternity care
BackgroundThe evidence on what strategies can improve recruitment to clinical trials in maternity care is lacking. As trial recruiters, maternity...
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A 12-month study of dialectical behavioral therapy for bοrderline patients suffering from eating disorders
PurposeIndividuals with eating disorders (ED) and comorbid borderline personality disorder (BPD) may benefit from therapies focusing on emotion...
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Dialectical Behavior Therapy and Acceptance and Commitment Therapy: Areas of Overlap and Distinction
Dialectical Behavior Therapy (DBT) and Acceptance and Commitment Therapy (ACT) are often grouped together as “third-wave” cognitive behavioral...
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A natural experiment to assess how urban interventions in lower socioeconomic areas influence health behaviors: the UrbASanté study
BackgroundMechanisms underlying the associations between changes in the urban environment and changes in health-related outcomes are complex and...
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A pilot study of the mistletoe and breast cancer (MAB) trial: a protocol for a randomised double-blind controlled trial
BackgroundA Cochrane review of mistletoe therapy concludes that there is some evidence that mistletoe extracts may offer benefits on measures of...
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Parkinson’s disease therapy: what lies ahead?
The worldwide prevalence of Parkinson’s disease (PD) has been constantly increasing in the last decades. With rising life expectancy, a longer...
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A resource-oriented intervention addressing balance in everyday activities and quality of life in people with advanced cancer: protocol for a feasibility study
BackgroundPeople with advanced cancer need to balance their resources and energy in order to experience enjoyment and quality of life in the time...
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Domiciliary monitoring of exhaled nitric oxide in the management of asthma: a pilot study
BackgroundWhether asthma patients could benefit from home monitoring for fractional exhaled nitric oxide (flow of 50 mL/s, Fe NO50 ) is unknown. We...
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Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine Versus Nimenrix in Healthy Adolescents: A Randomized Phase IIIb Multicenter Study
IntroductionMany immunization programs in Europe recommend quadrivalent meningococcal vaccinations, which are often administered concomitantly with...
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Endometriosis: patient–doctor communication and psychological counselling
The fact that endometriosis is one of the most frequent gynaecological disorders in women and girls is gradually attracting greater public and...
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The effect of an online acceptance and commitment intervention on the meaning-making process in cancer patients following hematopoietic cell transplantation: study protocol for a randomized controlled trial enhanced with single-case experimental design
BackgroundHematopoietic cell transplantation (HCT) is a highly invasive and life-threatening treatment for hematological neoplasms and some types of...
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Genicular Artery Embolisation in Patients with Osteoarthritis of the Knee (GENESIS 2): Protocol for a Double-Blind Randomised Sham-Controlled Trial
Knee osteoarthritis is a leading cause of chronic disability and economic burden. In many patients who are not surgical candidates, existing...
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Traditional Chinese medicine based on Tongjiang methodology combined with proton pump inhibitor (PPI) step-down in treating non-erosive reflux disease: a study protocol for a multicentered, randomized controlled clinical trial
BackgroundNon-erosive reflux disease (NERD) is characterized by typical gastroesophageal reflux symptoms, such as heartburn and regurgitation but an...
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based randomised controlled trial
BackgroundCombining short-acting nicotine replacement therapy with varenicline increases smoking cessation rates compared with varenicline alone, but...
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Cardiovascular risk and kidney function profiling using conventional and novel biomarkers in young adults: the African-PREDICT study
BackgroundLow- and middle-income countries experience an increasing burden of chronic kidney disease. Cardiovascular risk factors, including...
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Electronic Monitoring Devices to Support Inhalation Technique in Patients with Asthma: a Narrative Review
Purpose of ReviewImproper inhaling technique is common and is associated with poor patient outcomes. However, digital e-health devices may offer...
