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Green synthesis of nanohydroxyapatite trough Elaeagnus angustifolia L. extract and evaluating its anti-tumor properties in MCF7 breast cancer cell line
BackgroundOne of the most common types of cancer in women is breast cancer. There are numerous natural plant-based products, which exert anti-tumoral...
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Advanced nano-therapeutic delivery of metformin: potential anti-cancer effect against human colon cancer cells through inhibition of GPR75 expression
The high incidence rate coupled with significant mortality makes colorectal cancer one of the most prevalent and devastating cancers worldwide....
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Probucol attenuates high glucose-induced Müller cell damage through enhancing the Nrf2/p62 signaling pathway
PurposeThis study investigated the protective effect of probucol on Müller cells exposed to high glucose conditions and examined potential mechanisms...
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Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance
To identify molecules/pathways governing Venetoclax (VEN) sensitivity, we performed genome-wide CRISPR/Cas9 screens using a mouse AML line...
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Clinicopathologic and mutational profiles of primary breast diffuse large B cell lymphoma in a male patient: case report and literature review
IntroductionPrimary breast lymphoma (PBL) is rare, and most cases occur in female patients, with few reported cases in male patients. The clinical...
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Identification of a novel five ferroptosis-related gene signature as a promising prognostic model for breast cancer
BackgroundBreast cancer (BCa) is a major challenge for women’s health worldwide. Ferroptosis is closely related to tumorigenesis and cancer...
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Chidamide and orelabrutinib synergistically induce cell cycle arrest and apoptosis in diffuse large B-cell lymphoma by regulating the PI3K/AKT/mTOR pathway
ObjectiveThe initial therapeutic approach for diffuse large B-cell lymphoma (DLBCL) entails a rituximab, cyclophosphamide, doxorubicin, vincristine,...
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The usefulness of lutein/trypan blue vital dye for the staining of corneal endothelium: a pilot study on DMEK pretreated tissues
PurposeThe study aims to evaluate the usefulness of lutein/trypan blue vital dye for the staining of corneal tissues and endothelium–Descemet...
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Altered pathways and targeted therapy in double hit lymphoma
High-grade B-cell lymphoma with translocations involving MYC and BCL2 or BCL6 , usually referred to as double hit lymphoma (DHL), is an aggressive...
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Current Treatment Options in Relapsed and Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: a Review
Treatment of relapsed and refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) has changed dramatically over the past...
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Next-Generation Sequencing—Optimal Sequencing of Therapies in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL)
Purpose of ReviewThis research paper aims to provide an overview of evidence-based sequencing of therapies in relapsed/refractory chronic lymphocytic...
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JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia
Resistance to mitochondrial apoptosis predicts inferior treatment outcomes in patients with diverse tumor types, including T-cell acute lymphoblastic...
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EBV-positive follicular lymphoma and concurrent EBV-negative diffuse large B-cell lymphoma illustrating branched evolution model and “Hit and Run” hypothesis
Epstein-Barr virus (EBV) is one of the most common viruses associated with multiple malignancies including hematopoietic, epithelial, and mesenchymal...
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Hsa_circ_0003928 regulates the progression of diabetic nephropathy through miR-136-5p/PAQR3 axis
BackgroundDiabetic nephropathy (DN) is one of the complications of diabetes and has a high mortality, but its specific pathogenesis is not clear. In...
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Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation
Follicular lymphomas with plasmacytic differentiation (FL-PCD) include two major subtypes: one with predominantly interfollicular PCD that usually...
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Immunophenotypic analysis of angiomyolipoma with epithelial cysts, comparison to mixed epithelial and stromal tumors and epithelial and stromal elements of normal kidney and ovaries
Angiomyolipoma with epithelial cysts (AMLEC) is a rare variant of renal angiomyolipoma (AML). It is characterized by a conventional AML component...
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PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer
PU.1 is a key transcription factor that modulates hematopoietic cell differentiation and is involved in various physiological and pathological...
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Investigation of the Therapeutic Effect of Salbutamol on Endometriosis in a Mouse Model
Endometriosis is an immune chronic inflammatory disease, and there are currently no more effective drugs for treating endometriosis due to its...
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Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer
BackgroundPancreatic cancer is aggressive with no symptoms until the advanced stage reached. The increased resistance of pancreatic cancer to...
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Protein kinase RNA-activated controls mitotic progression and determines paclitaxel chemosensitivity through B-cell lymphoma 2 in ovarian cancer
Anti-tubulin agents, such as paclitaxel, have been used extensively for treatment of several types of cancer, including ovarian, lung, breast, and...
