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Phagocytosis model of calcium oxalate monohydrate crystals generated using human induced pluripotent stem cell-derived macrophages
Macrophages play a role in nephrolithiasis, offering the possibility of develo** macrophage-mediated preventive therapies. To establish a system...
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Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets
The prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of...
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Titin and CK2α are New Intracellular Targets in Acute Insulin Application-Associated Benefits on Electrophysiological Parameters of Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic Syndrome Rats
BackgroundPrevious studies have demonstrated that a high-carbohydrate intake could induce metabolic syndrome (MetS) in male rats with marked cardiac...
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The Contractile Response to Oxytocin in Non-pregnant Rat Uteri Is Modified After the First Pregnancy
During pregnancy, the uterus undergoes several modifications under the influence of hormonal and mechanical stimuli. We hypothesize that while most...
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Right and left ventricular blood pool T2 ratio on cardiac magnetic resonance imaging correlates with hemodynamics in patients with pulmonary hypertension
ObjectivesOur objective is to compare the right/left ventricular blood pool T1 ratio (RVT1/LVT1), and right/left ventricular blood pool T2 ratio...
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Nanoemulsion potentiates the anti-cancer activity of Myricetin by effective inhibition of PI3K/AKT/mTOR pathway in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) is a heterogeneous tumor with a poor prognosis and high metastatic potential, resulting in poor clinical...
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Novel Schiff bases of Vanillin: potent inhibitors of macrophage harbored Leishmania tropica
Due to limited chemotherapeutic options for leishmaniasis, novel synthetic compounds are gaining attention for evaluation against leishmaniasis. This...
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Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
Cisplatin, a classical platinum-based chemotherapy agent, has been a frontline treatment for various cancers for decades. However, its effectiveness...
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Immunomodulation of Proton-activated G Protein-coupled Receptors in Inflammation
Proton-activated G protein-coupled receptors (GPCRs), initially discovered by Ludwig in 2003, are widely distributed in various tissues. These...
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Protease secretions by the invading blastocyst induce calcium oscillations in endometrial epithelial cells via the protease-activated receptor 2
BackgroundEarly embryo implantation is a complex phenomenon characterized by the presence of an implantation-competent blastocyst and a receptive...
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Rapid Effects of Oestrogen on Intracellular Ca2+ in the Uterine Junctional Myometrium of Patients With and Without Adenomyosis in Different Phases of the Menstrual Cycle
We investigated the role of oestrogen receptor 1 (ESR1) in regulating the [Ca 2+ ]i concentration in the junctional zone (JZ) and its effect on...
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The role of the HERG channel in the secretion of glucagon-like peptide-1 (GLP-1) from murine intestinal L-cells
The HERG ion channel belongs to the voltage-gated potassium (Kv) channel family and is involved in potassium efflux during cellular repolarization....
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Novel SLFN14 mutation associated with macrothrombocytopenia in a patient with severe haemorrhagic syndrome
BackgroundPlatelet-type bleeding disorder 20 (BDPLT20), as known as SLFN14-related thrombocytopenia, is a rare inherited thrombocytopenia (IT)....
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Assessment of genotypes, endosymbionts and clinical characteristics of Acanthamoeba recovered from ocular infection
IntroductionAcanthamoeba is an emerging pathogen, infamous for its resilience against antiprotozoal compounds, disinfectants and harsh environments....
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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission and Ca2+ homeostasis in a murine model of HFpEF
Heart failure with preserved ejection fraction (HFpEF) displays normal or near-normal left ventricular ejection fraction, diastolic dysfunction,...
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The role of PCSK9 in glomerular lipid accumulation and renal injury in diabetic kidney disease
Aims/hypothesisGlomerular lipid accumulation is a defining feature of diabetic kidney disease (DKD); however, the precise underlying mechanism...
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Semen quality and metabolic profile in people with type 1 diabetes with and without erectile dysfunction: a cross-sectional study
PurposeThe aim of the present study is to evaluate the association of metabolic and glycemic variables with semen parameters in patients with type 1...
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Triiodo-L-thyronine (T3) downregulates Npr1 gene (coding for natriuretic peptide receptor-A) transcription in H9c2 cells: involvement of β-AR-ROS signaling
IntroductionNatriuretic peptide receptor-A (NPR-A) signaling system is considered as an intrinsic productive mechanism of the heart that opposes...
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Short term effect of intravenous treprostinil in term and preterm infants with pulmonary hypertension
BackgroundPulmonary hypertension (PH) is a life-threatening condition in newborns. We aimed to assess the clinical and echocardiographic responses of...
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Nano-calcium incorporated piscean collagen scaffolds: potential wound dressing material
BackgroundCollagen proteins extracted from piscean sources are alternatives to bovine and porcine collagen because of their abundance, low price, and...
