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Apoptotic changes in the intestinal epithelium of Cryptosporidium-infected mice after silver nanoparticles treatment versus nitazoxanide
Cryptosporidium has been identified as one of the prevalent opportunistic parasites that cause diarrhea, which may be persistent and fatal. Current...
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The comparative anti-cancer effects of krill oil and oxaliplatin in an orthotopic mouse model of colorectal cancer
BackgroundOur in vitro studies demonstrated that krill oil (KO) has anti-cancer potential. This study aimed to compare the anti-cancer effects of KO...
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Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity
PurposeStrobilurins act as antifungal agents by inhibiting the mitochondrial respiratory chain. The cytotoxic activity of strobilurins, focusing on...
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Neuroprotective effects of ammonium tetrathiomolybdate, a slow-release sulfide donor, in a rodent model of regional stroke
BackgroundSeveral therapeutic strategies to rescue the brain from ischemic injury have improved outcomes after stroke; however, there is no treatment...
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Extracellular vesicle-microRNAs mediated response of bovine ovaries to seasonal environmental changes
BackgroundAmong the various seasonal environmental changes, elevated ambient temperature during the summer season is a main cause of stress in dairy...
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Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model
BackgroundTo describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species...
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Atovaquone enhances antitumor efficacy of TCR-T therapy by augmentation of ROS-induced ferroptosis in hepatocellular carcinoma
T-cell receptor (TCR) engineered T-cell therapy has recently emerged as a promising adoptive immunotherapy approach for tumor treatment, yet hindered...
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Neuroactive steroids in the neuroendocrine control of food intake, metabolism, and reproduction
Neuroactive steroids are a type of steroid hormones produced within the nervous system or in peripheral glands and then transported to the brain to...
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Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest
BackgroundBrain injury is a leading cause of morbidity and mortality in patients resuscitated from cardiac arrest. Mitochondrial dysfunction...
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Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host...
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A new parameter in multiple myeloma: CYP3A4*1B single nucleotide polymorphism
Multiple myeloma (MM) is a disease caused by malignant plasma cells, causing free light chain release accompanying the increase in monoclonal...
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Flavonoid-Rich Extract of Oldenlandia diffusa (Willd.) Roxb. Inhibits Gastric Cancer by Activation of Caspase-Dependent Mitochondrial Apoptosis
ObjectiveTo evaluate the apoptosis and cycle arrest effects of Oldenlandia diffusa flavonoids on human gastric cancer cells, determine the action...
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Mitochondrial disorders as a mechanism for the development of obese Sarcopenia
Obese sarcopenia is a severe and prevalent disease in an aging society. Compared to sarcopenia alone, the development and advanced stage of obesity...
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Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment
PurposeAn oral docetaxel formulation boosted by the Cytochrome P450 (CYP) 3 A inhibitor ritonavir, ModraDoc006/r, is currently under clinical...
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Population Pharmacokinetics of Upadacitinib Using the Immediate-Release and Extended-Release Formulations in Healthy Subjects and Subjects with Rheumatoid Arthritis: Analyses of Phase I–III Clinical Trials
Background and ObjectivesUpadacitinib is a selective Janus kinase (JAK) 1 inhibitor being developed as an orally administered treatment for patients...
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Norwogonin attenuates hypoxia-induced oxidative stress and apoptosis in PC12 cells
BackgroundNorwogonin is a natural flavone with three phenolic hydroxyl groups in skeletal structure and has excellent antioxidant activity. However,...
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Case report of congenital methemoglobinemia: an uncommon cause of neonatal cyanosis
BackgroundMethemoglobinemia can be an acquired or congenital condition. The acquired form occurs from exposure to oxidative agents. Congenital...
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Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can...
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Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca 2+ release is essential to boost energy production in ventricular...
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Clinical Pharmacokinetics of Metoprolol: A Systematic Review
BackgroundMetoprolol is recommended for therapeutic use in multiple cardiovascular conditions, thyroid crisis, and circumscribed choroidal...
