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Benefits of Trimodality Therapy Compared with Systemic Therapy Alone in Male Patients with Stage IV Breast Cancer
BackgroundMale breast cancer (MBC) represents <1% of all breast cancer (BC) diagnoses. Recent publications in female stage IV BC have shown that...
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Photobiomodulation Therapy: A New Light in the Treatment of Systemic Sclerosis Skin Ulcers
IntroductionSkin ulcers (SU) represent one of the most frequent manifestations of systemic sclerosis (SSc), occurring in almost 50% of scleroderma...
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The preoperative systemic immune-inflammation index is associated with an unfavorable prognosis for patients undergoing curative resection of esophageal squamous cell carcinoma after neoadjuvant therapy
PurposesSystemic inflammation and immune status play a critical role in the development and progression of cancers. We evaluated the clinical...
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Association of systemic inflammation with shock severity, 30-day mortality, and therapy response in patients with cardiogenic shock
BackgroundMortality in cardiogenic shock (CS) remains high even when mechanical circulatory support (MCS) restores adequate circulation. To detect a...
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Outcome of patients with biochemical recurrence of prostate cancer after PSMA PET/CT-directed radiotherapy or surgery without systemic therapy
BackgroundRadiotherapy (RT) and surgery are potential treatment options in patients with biochemical recurrence (BCR) following primary prostate...
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Systemic therapy for early-stage breast cancer: learning from the past to build the future
The treatment of breast cancer has improved dramatically over the past century, from a strictly surgical approach to a coordinated one, including...
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Real-World Effectiveness of Newly Initiated Systemic Therapy for Atopic Dermatitis in the United States: A Claims Database Analysis
IntroductionAtopic dermatitis (AD) is associated with significant quality-of-life and economic burdens. Real-world evidence is needed to identify...
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The therapeutic effect of radiotherapy combined with systemic therapy compared to radiotherapy alone in patients with simple brain metastasis after first-line treatment of limited-stage small cell lung cancer: a retrospective study
PurposeWe aimed to compare the therapeutic effect of radiotherapy (RT) plus systemic therapy (ST) with RT alone in patients with simple brain...
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Ceftazidime-avibactam combination therapy versus monotherapy for treating carbapenem-resistant gram-negative infection: a systemic review and meta-analysis
BackgroundThis meta-analysis was conducted to compare the efficacy of ceftazidime-avibactam combination therapy with that of monotherapy in the...
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TIPS plus sequential systemic therapy of advanced HCC patients with tumour thrombus-related symptomatic portal hypertension
ObjectivesPortal vein tumour thrombus (PVTT)–related symptomatic portal hypertension (SPH) leads to a poor prognosis in hepatocellular carcinoma...
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Clinical features and response to systemic therapy in NRAS-mutant Chinese melanoma patients
PurposeThe prognosis of patients with NRAS-mutant melanoma is rather poor. Immunotherapy and targeted therapy have revolutionized anti-tumor therapy,...
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[177Lu]Lu-PSMA-617 as first-line systemic therapy in patients with metastatic castration-resistant prostate cancer: a real-world study
PurposeThe use of [ 177 Lu]Lu-PSMA-617 radioligand therapy has become increasingly recognized as a viable therapeutic approach for patients in the...
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Real-world systemic sequential therapy with regorafenib for recurrent hepatocellular carcinoma: analysis of 93 cases from a single center
BackgroundRegorafenib is an oral multikinase inhibitor and became the first second-line systemic treatment for hepatocellular carcinoma (HCC)...
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Systemic immune-inflammation index predicts the clinical outcomes in patients with acute uncomplicated type-B aortic dissection undergoing optimal medical therapy
BackgroundOptimal medical therapy (OMT) for uncomplicated type B aortic dissection (uTBAD) provides excellent short-term outcomes during follow up;...
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Effect and safety profile of belimumab and tacrolimus combination therapy in thirty-three patients with systemic lupus erythematosus
Introduction/objectivesBelimumab combined with mycophenolate mofetil has been proven to be effective for treating systemic lupus erythematosus (SLE)...
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A Preliminary Examination of the Effects and Mechanisms of Cognitive Behavioral Therapy for Insomnia on Systemic Inflammation Among Patients with Knee Osteoarthritis
BackgroundSystemic inflammation, particularly the elevation of interleukin-6 (IL-6), plays an important role in the maintenance and progression of...
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Pregnancy outcomes in patients receiving assisted reproductive therapy with systemic lupus erythematosus: a multi-center retrospective study
ObjectivesTo evaluate the safety, efficacy, and maternal and fetal outcomes of assisted reproductive therapy (ART) in systemic lupus erythematosus...
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Validation of prognostic and predictive value of total tumoral load after primary systemic therapy in breast cancer using OSNA assay
PurposeThis study aimed to validate the classification of breast cancer (BC) patients in progression risk groups based on total tumor load (TTL)...
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Tocilizumab Therapy for Treatment-Resistant Systemic Lupus Erythematosus with Elevated IL-6 and CRP Levels: a Case Report
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with variable clinical manifestations and treatment responses. Different cytokines...
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Trends and drivers of pharmaceutical expenditures from systemic anti-cancer therapy
Expenditures on medicine for systemic anti-cancer therapy (SACT) have seen large increases in recent years. The characterization of patients with...
