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TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis
ObjectiveTransferrin receptor-1 (TfR1) plays important roles in controlling cellular iron levels, but its role in OA pathology is unknown. Herein we...
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Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy
Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead...
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Circ ASAP2 decreased inflammation and ferroptosis in diabetic nephropathy through SOX2/SLC7A11 by miR-770-5p
AimsDiabetes nephropathy (DN) is one of the major complications in diabetes. With the improvement of people’s living standards in China in recent...
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The Role of Ferroptosis in Placental-Related Diseases
Ferroptosis is a recently identified form of programmed cell death which is different from apoptosis, pyroptosis, necrosis, and autophagy. It is...
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Dual PI3K/HDAC Inhibitor BEBT-908 Exhibits Potent Efficacy as Monotherapy for Primary Central Nervous System Lymphoma
BackgroundThe efficacy of systemic treatment for primary central nervous system lymphoma (PCNSL) is limited because of the blood–brain barrier (BBB)...
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Targeting BMAL1 reverses drug resistance of acute myeloid leukemia cells and promotes ferroptosis through HMGB1-GPX4 signaling pathway
PurposeAcute myeloid leukemia (AML) is a refractory hematologic malignancy that poses a serious threat to human health. Exploring alternative...
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Bronchopulmonary dysplasia: analysis and validation of ferroptosis-related diagnostic biomarkers and immune cell infiltration features
BackgroundEarly and precise diagnosis of bronchopulmonary dysplasia (BPD) is essential to improve the prognosis of preterm infants with BPD. Studying...
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Insight into Cardioprotective Effects and Mechanisms of Dexmedetomidine
PurposeCardiovascular disease remains the leading cause of death worldwide. Dexmedetomidine is a highly selective α2 adrenergic receptor agonist with...
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Vimentin is required for tumor progression and metastasis in a mouse model of non–small cell lung cancer
Vimentin is highly expressed in metastatic cancers, and its expression correlates with poor patient prognoses. However, no causal in vivo studies...
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Apatinib combined with olaparib induces ferroptosis via a p53-dependent manner in ovarian cancer
ObjectivePARP inhibitors combined with antiangiogenic drugs have been reported to improve outcomes in BRCA wild-type ovarian cancer patients, the...
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Long noncoding RNA CASC11 suppresses sorafenib-triggered ferroptosis via stabilizing SLC7A11 mRNA in hepatocellular carcinoma cells
As a frontline treatment for patients with advanced hepatocellular carcinoma (HCC), sorafenib is an effective drug approved by the Food and Drug...
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CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis
Previous studies have demonstrated that circST6GALNAC6 is a tumor suppressor in bladder cancer. However, the role of circST6GALNAC6 in ferroptosis...
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Pharmacological inhibition of the LIF/LIFR autocrine loop reveals vulnerability of ovarian cancer cells to ferroptosis
Of all gynecologic cancers, epithelial-ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who...
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Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
Cisplatin, a classical platinum-based chemotherapy agent, has been a frontline treatment for various cancers for decades. However, its effectiveness...
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Research advances in the understanding of how exosomes regulate ferroptosis in cancer
Exosomes are extracellular vesicles that can release different bioactive substances to affect tumor cells and cell death pathways. As an important...
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Quercetin inhibits the progression of endometrial HEC-1-A cells by regulating ferroptosis—a preliminary study
BackgroundEndometrial carcinoma (EC) is one of the most common female reproductive system tumors, which seriously threatens women's health. This...
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RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis
Medulloblastoma (MB) is a prevalent malignant brain tumor among children, which can be classified into four primary molecular subgroups. Group 3 MB...
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Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-dependent, lipid peroxidation-driven membrane destruction that can...
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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia
Resistance to apoptosis in acute myeloid leukemia (AML) cells causes refractory or relapsed disease, associated with dismal clinical outcomes....
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Hsp90α and cell death in cancers: a review
Heat shock protein 90α (Hsp90α), an important molecular chaperone, plays a crucial role in regulating the activity of various intracellular signaling...
