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Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH
The ability of the multidrug resistance modifiers R- and R,S-verapamil (VPL), cyclosporine A (CsA) and its non-immunosuppressive derivative SDZ PSC...
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Polarisierte Monolayerkulturen zur In-vitro-Untersuchung des intestinalen P-Glykoproteinmediierten Transports
Background: Mechanisms of drug resistance both at the tumor and cellular level are mainly responsible for the observed low response rates and... -
Multidrug resistance in human cancer
Resistance to cytotoxic chemotherapy continues to be a major obstacle to more effective treatment of human cancers. A particular problem in clinical...
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P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells
The multidrug transporter, P-glycoprotein (P-gp), is expressed by CD34-positive bone marrow cells, which include hematopoietic stem cells, and in...
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The chemosensitizer cyclosporin A enhances the toxic side-effects of doxorubicin in the rat
the feasibility of using chemosensitizers in the circumvention of P-glycoprotein-mediated multidrug resistance has been shown in many studies. We...
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Clinical Pharmacokinetics of Paclitaxel
Paclitaxel is a new anticancer agent showing significant promise as therapy for solid tumours and leukaemia, given alone or in combination with other...
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Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance
A series of five potential modulators of resistance were tested for their relative ability, as compared with verapamil, to sensitize CEM...
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Pharmacokinetic Drug Interactions with Anticancer Drugs
Drug dosage is of paramount importance in the treatment of cancer, the aim being to optimise drug exposure with a view to maximising antitumour...
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Multidrug resistance in cancer chemotherapy
Resistance to chemotherapy is the single most important reason for treatment failure in cancer patients. Over the past 15 years, we have gained...
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In vitro and in vivo chemosensitizing effect of cyclosporin A on an intrinsic multidrug-resistant rat colon tumour
Colon tumours are intrinsically resistant to chemotherapy and most of them express the multidrug transporter P glycoprotein (Pgp). Whether this Pgp...
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Modulation of drug cytotoxicity in wild-type and multidrug-resistant tumor cells by stereoisomeric series of C-20′-vinblastine congeners that lack antimicrotubule activity
Seven binary vinca alkaloid congeners were newly synthesized as the C14′ or C16′(20′) or C14′16′(20′) stereoisomers of C20′-modified VBL. These...
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Reversal of typical multidrug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing themdr1 phenotype
The new non-immunosuppressive cyclosporin derivative SDZ PSC 833 (PSC) is a potent agent used to overcome typical multidrug resistance (MDR)...
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Comparison of cyclosporin A and SDZ PSC833 as multidrug-resistance modulators in a daunorubicin-resistant Ehrlich ascites tumor
Recent studies by Boesch et al. have demonstrated that a nonimmunosuppressive cyclosporin analog, SDZ PSC 833 (an analog of cyclosporin D), is an...
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In vitro analysis of drug resistance in tumor cells from patients with acute myelocytic leukemia
A 72 hours fluorometric microculture cytotoxicity assay (FMCA) was used for the study of chemotherapeutic drug resistance in tumor cell suspensions...