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Modified DEP regimen as induction therapy for lymphoma-associated hemophagocytic lymphohistiocytosis: a prospective, multicenter study
PurposeHemophagocytic lymphohistiocytosis (HLH), especially lymphoma-associated HLH (LA-HLH), is a refractory immune disorder with high mortality....
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EZH2 expression is associated with inferior overall survival in mantle cell lymphoma
Enhancer of zeste homolog 2 (EZH2) is a catalytic component of the polycomb repressive complex 2 (PRC2) which reduces gene expression via...
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Early Progressing Follicular Lymphoma
Purpose of ReviewFollicular lymphoma is an indolent lymphoma which does not limit life expectancy in most patients; however, approximately 20% of...
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Important Considerations in the Diagnosis and Management of Post-transplant Lymphoproliferative Disorder
Purpose of ReviewA relative lack of molecular and clinical studies compared to other lymphoid cancers has historically made it difficult to determine...
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Diagnostic and prognostic molecular pathology of lymphoid malignancies
With the explosion in knowledge about the molecular landscape of lymphoid malignancies and the increasing availability of high throughput techniques,...
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Hematopoietic Cell Transplantation and Adoptive Cell Therapy in Peripheral T Cell Lymphoma
Purpose of ReviewPeripheral T cell lymphomas (PTCLs) are a heterogeneous group of diseases and represent approximately 10–15% of all non-Hodgkin...
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Estimating the global burden of Epstein–Barr virus-related cancers
BackgroundMore than 90% of the adult population globally is chronically infected by the Epstein–Barr virus (EBV). It is well established that EBV is...
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Central nervous system ALK-negative anaplastic large cell lymphoma with IRF4/DUSP22 rearrangement
Anaplastic large cell lymphomas (ALCL) are mature T-cell neoplasms, approximately half of which harbor rearrangements of the ALK gene that confer a...
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Targeted based therapy in nodal T-cell lymphomas
T-cell lymphomas (TCL) are a group of biologically and clinically heterogenous neoplasms derived from mature T lymphocytes. Recent findings in...
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The Short-Term Efficacy and Safety of Brentuximab Vedotin Plus Cyclophosphamide, Epirubicin and Prednisone in Untreated PTCL: A Real-World, Retrospective Study
IntroductionBrentuximab vedotin (BV) showed high overall remission rates in refractory/relapsed classical Hodgkin’s lymphoma (HL) and systemic...
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Non-Hodgkin lymphoma after pediatric kidney transplantation
Non-Hodgkin lymphoma (NHL) that develops after kidney transplantation belongs to post-transplant lymphoproliferative disorders (PTLD) occurring with...
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Combined gemcitabine, cisplatin, dexamethasone, methotrexate, and pegaspargase (GDP-ML) for patients with newly diagnosed extranodal natural killer/T cell lymphoma, nasal type: a single arm, single center, prospective phase 2 study
Extranodal natural killer/T cell lymphoma, nasal type (ENKL) is a highly aggressive tumor with relatively poor prognosis. In this prospective study,...
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Novel Therapies for Follicular Lymphoma and Other Indolent Non-Hodgkin Lymphomas
When selecting therapy for patients with indolent non-Hodgkin lymphoma (iNHL) including follicular (FL), marginal zone (MZL), small lymphocytic...
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Current Role of Functional Imaging in the Management of Lymphoma
Purpose of ReviewFunctional imaging with 18FDG-PET-CT has transformed the staging and response assessment of patients with Hodgkin (HL) and...
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PD-1/PD-L1 Pathway and Its Blockade in Patients with Classic Hodgkin Lymphoma and Non-Hodgkin Large-Cell Lymphomas
Purpose of ReviewProgrammed cell death protein-1 (PD-1) is currently the most extensively studied inhibitory checkpoint molecule. Many malignant...
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Cellular Immunotherapy in Lymphoma: Beyond CART Cells
Cellular immunotherapy has been rapidly evolving and increasingly utilized in the management of relapsed and refractory lymphoma. CD19-specific...
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Evaluation of prognosis following early disease progression in peripheral T-cell lymphoma
Recently, progression of disease within 24 months (POD24) has been demonstrated as a strong prognostic indicator in various types of malignant...
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Busulfan, etoposide, cytarabine, and melphalan as a high-dose regimen for autologous stem cell transplantation in peripheral T-cell lymphomas
Given the unsatisfactory survival in patients who received high-dose chemotherapy followed by autologous stem cell transplantation (ASCT) for...
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Nitrosourea, etoposide and cyclophosphamide followed by autologous stem cell transplantation for pediatric lymphoma patients
Treatment outcomes in pediatric lymphoma have improved substantially over the past 2 decades; however, the prognosis for patients with high risk or...
