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Maribavir: First Approval
Maribavir (LIVTENCITY TM ), a cytomegalovirus (CMV) enzyme pUL97 kinase inhibitor, is being developed by Takeda Pharmaceuticals for the treatment of...
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Oteseconazole: First Approval
Oteseconazole (VIVJOA™) is an orally administered azole antifungal agent developed by Mycovia Pharmaceuticals for the treatment of fungal infections....
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Vutrisiran: First Approval
Vutrisiran (AMVUTTRA™) is a subcutaneously administered transthyretin-directed small interfering ribonucleic acid (siRNA) therapeutic (also called...
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Healthcare costs of patients with chronic obstructive pulmonary disease in Denmark – specialist care versus GP care only
BackgroundMany patients with chronic obstructive pulmonary disease (COPD) are treated in general practice only and have never received specialist...
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Intraoperatives Floppy-Iris-Syndrom – Gibt es Neuigkeiten zur systemischen Medikation?
BackgroundIntraoperative floppy iris syndrome (IFIS) is known to be a potential cause of serious complications during cataract surgery. Multiple...
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Why is There Discordance between the Reimbursement of High-Cost ‘Life-Extending’ Pharmaceuticals and Medical Devices? The Funding of Ventricular Assist Devices in Australia
New health technologies often yield health benefits, but often at a high cost. In Australia, the processes for public reimbursement of high-cost...
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Daridorexant: First Approval
Daridorexant (Quviviq™; Idorsia Pharmaceuticals Ltd.) is an orally administered dual orexin type 1 and type 2 (OX 1 and OX 2 ) receptor antagonist...
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Ganaxolone: First Approval
Ganaxolone (ZTALMY ® ; Marinus Pharmaceuticals) is a synthetic neuroactive steroid that acts as a positive allosteric modulator of the...
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Okuläre Nebenwirkungen von Dupilumab – Übersichtsarbeit und Therapieempfehlung der „Kommission für Trockenes Auge und Oberflächenerkrankungen“ der Österreichischen Ophthalmologischen Gesellschaft (ÖOG)
Dupilumab (Dupixent®, Sanofi and Regeneron Pharmaceuticals) is a human monoclonal antibody against the interleukin (IL)-4 receptor alpha subunit of...
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PrAna: an R package to calculate and visualize England NHS primary care prescribing data
BackgroundThe objective of this work to calculate prescribed quantity of an active pharmaceutical ingredient (API) in prescription medications for...
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How to Predict Drug Expenditure: A Markov Model Approach with Risk Classes
BackgroundAlthough pharmaceutical expenditures have been rising for decades, the question of their drivers remains unclear, and long-term projections...
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Towards Improving the Efficacy of PSMA-Targeting Radionuclide Therapy for Late-Stage Prostate Cancer—Combination Strategies
Purpose of Review[ 177 Lu]Lu-PSMA-617 is a radiopharmaceutical that emits beta-minus radiation and targets prostate-specific membrane antigen...
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Healthcare provider and medical cannabis patient communication regarding referral and medication substitution: the Canadian context
BackgroundPatients use medical cannabis for a wide array of illnesses and symptoms, and many substitute cannabis for pharmaceuticals. This...
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Carboxymethylcellulose excipient allergy: a case report
BackgroundExcipients are widely used in pharmaceuticals, detergents, food, and drink because of their properties of low toxicity and...
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Case of a 6-year-old boy with anaphylaxis induced by erythritol with positive skin prick test and negative basophil activation test
Erythritol is widely used as an additive in foods and pharmaceuticals. We present the case of a 6-year-old boy who developed an allergy to...
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Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
AbstractNon-targeted analysis (NTA) and suspect screening analysis (SSA) are powerful techniques that rely on high-resolution mass spectrometry...
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Sugemalimab: First Approval
Sugemalimab (Cejemly ® in China) is a fully human, full length, anti-programmed death ligand 1 (PD-L1) immunoglobulin G4 (IgG4) monoclonal antibody...
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Maralixibat: First Approval
Maralixibat (Livmarli™) is an orally-administered, small-molecule ileal bile acid transporter (IBAT) inhibitor being developed by Mirum...
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Direct and indirect savings from parallel imports in Sweden
BackgroundThe aim was: i) to quantify the direct and indirect savings from parallel imports in Sweden during a period when sellers were forbidden...