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Caring for the hypertensive newborn: a prospective evaluation of risk factors, clinical profile, management, and predictors of outcome of neonatal hypertension
With the advancement of neonatal care and routine blood pressure monitoring, neonatal hypertension (NHT) has been increasingly recognised over the...
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Two single lung transplantations from one donor: lung twinning in the LAS era
ObjectivesThe implementation of the Lung Allocation Score (LAS) in the Eurotransplant international collaborative framework decreased waiting list...
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In vivo genome-wide CRISPR screening identifies CITED2 as a driver of prostate cancer bone metastasis
Most cancer deaths are due to metastatic dissemination to distant organs. Bone is the most frequently affected organ in metastatic prostate cancer...
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The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
Breast cancer is the most common cancer worldwide, with an estimated 2.3 million new cases diagnosed every year. Effective measures for cancer...
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Venoarterial extracorporeal membrane oxygenation in immunocompromised patients with cardiogenic shock: a cohort study and propensity-weighted analysis
PurposeThe outcomes of immunocompromised patients with cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation (VA-ECMO) are...
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ECMO as a bridge to cardiac surgery: stabilizing unstable patients for a definitive procedure
IntroductionExtracorporeal membrane oxygenation (ECMO) in adults has been used in post-cardiotomy patients who decline hemodynamically. Cardiogenic...
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Donation after circulatory death (DCD)—lung procurement
The number of lungs available for lung transplantation is far lower than the number of patients awaiting them. Consequently, there is a significant...
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Joint report on terminology for surgical procedures to treat pelvic organ prolapse
Surgeries for pelvic organ prolapse (POP) are common, but standardization of surgical terms is needed to improve the quality of investigation and...
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Identification of Pregnancy Adverse Drug Reactions in Pharmacovigilance Reporting Systems: A Novel Algorithm Developed in EudraVigilance
IntroductionThere is a need to strengthen the evidence base regarding medication use during pregnancy and to facilitate the early detection of safety...
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3.0 T diffusion tensor imaging and fiber tractography of the testes in nonobstructive azoospermia
PurposeTo assess the role of 3.0 T Diffusion Tensor Imaging (DTI) and Fiber Tractography (FT) of the testes in the work-up of nonobstructive...
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Transvaginal versus transabdominal specimen extraction in minimally invasive surgery: a systematic review and meta-analysis
AimNatural orifice specimen extraction (NOSE) is an alternative to conventional transabdominal retrieval. We aimed to compare outcomes following...
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Normothermic Regional Perfusion in Donation After Circulatory Death for Liver Transplantation: A Narrative Review
Purpose of ReviewNormothermic regional perfusion (NRP) is an emerging procurement technique intended to increase the quantity and quality of...
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EXCHANGE-2: investigating the efficacy of add-on plasma exchange as an adjunctive strategy against septic shock—a study protocol for a randomized, prospective, multicenter, open-label, controlled, parallel-group trial
BackgroundSepsis is as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. The mortality of sepsis and...
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Comparative safety of immune checkpoint inhibitors in recurrent or metastatic head and neck squamous cell carcinoma: a systematic review and network meta-analysis
BackgroundTo indirectly compare the safety of immune checkpoint inhibitors (ICIs) in the treatment of recurrent or metastatic head and neck squamous...
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Tumor heterogeneity and clinically invisible micrometastases in metastatic breast cancer—a call for enhanced surveillance strategies
The biology of metastatic breast cancer (MBC) is understudied, primarily due to the difficulty of procuring multiple samples from patients with...
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The Alexis® system for laparoscopic splenectomy in pediatric patients
The laparoscopic splenectomy in pediatric patients is performed worldwide but often the disproportion between size of patients and size of organs...
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The Fenice project to evaluate and improve the quality of healthcare in high-dependency care units: results after the first year
High-Dependency care Units (HDUs) have been introduced worldwide as intermediate wards between Intensive Care Units (ICUs) and general wards....
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Laparoscopic segmental colectomy with extensive D3 lymph node dissection: a good choice for right transverse colon cancer
BackgroundPrevious research was yet to establish a definite operation for transverse colon cancer (TCC); surgical procedure was often dictated by the...
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PCSK9 Inhibitors and Infection-Related Adverse Events: A Pharmacovigilance Study Using the World Health Organization VigiBase
AimsProtein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are novel lipid-lowering agents used in patients with cardiovascular disease....
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Post-induction hypotension and intraoperative hypotension as potential separate risk factors for the adverse outcome: a cohort study
PurposeIntraoperative hypotension (IOH) is associated with organ hypoperfusion. There are different underlying causes of IOH depending on the phase...