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Ketamine in the Past, Present, and Future: Mechanisms, Metabolites, and Toxicity
Purpose of ReviewWhile ketamine’s analgesia has mostly been attributed to antagonism of N-methyl- d -aspartate receptors, evidence suggests multiple...
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Distinctive alterations in the functional anatomy of the cerebral cortex in pain-sensitized osteoarthritis and fibromyalgia patients
BackgroundPain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common...
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MRI grading of spinal stenosis is not associated with the severity of low back pain in patients with lumbar spinal stenosis
BackgroundAlthough lumbar spinal stenosis (LSS) often coexists with other degenerative conditions, few studies have fully assessed possible...
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Magnetic resonance spectroscopy (MRS) identification of chemically painful lumbar discs leads to improved 6-, 12-, and 24-month outcomes for discogenic low back pain surgeries
PurposeMRS was shown to reliably quantify relative levels of degenerative pain biomarkers, differentiating painful versus non-painful discs in...
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Systematic Review and Meta-analysis Seem to Indicate that Cannabinoids for Chronic Primary Pain Treatment Have Limited Benefit
IntroductionThe IASP ICD-11 chronic primary pain (CPP) definition includes 19 different painful conditions. In recent years, interest in the...
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Management of Musculoskeletal Pain: An Update with Emphasis on Chronic Musculoskeletal Pain
Musculoskeletal pain is a challenging condition for both patients and physicians. Many adults have experienced one or more episodes of...
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Neuropathic pain in knee osteoarthritis
BackgroundThis study aimed to investigate the relationship between the neuropathic pain in knee osteoarthritis with the body composition,...
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Complex Regional Pain Syndrome: Evidence-Based Advances in Concepts and Treatments
Purpose of ReviewThis review presents the most current information about the epidemiology of complex regional pain syndrome (CRPS), classification...
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Consensus recommendations on dosing and administration of medical cannabis to treat chronic pain: results of a modified Delphi process
BackgroundGlobally, medical cannabis legalization has increased in recent years and medical cannabis is commonly used to treat chronic pain. However,...
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Discomfort, pain and stiffness: what do these terms mean to patients? A cross-sectional survey with lexical and qualitative analyses
BackgroundWhile pain is often the focus of clinical interventions, other clinical outcomes (e.g., discomfort, stiffness) might also contribute to...
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Noziplastischer Schmerz in Forschung und Praxis
Traditionally, two mechanistic pain categories were distinguished: nociceptive and neuropathic pain. After the definitions of these two mechanistic...
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A drug free solution for improving the quality of life of fibromyalgia patients (Fibrepik): study protocol of a multicenter, randomized, controlled effectiveness trial
BackgroundFibromyalgia is a form of chronic widespread pain that is defined as a syndrome of chronic symptoms of moderate to severe intensity,...
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Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study
BackgroundPain and fatigue are persistent problems in people with rheumatoid arthritis. Central sensitisation (CS) may contribute to pain and...
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Fibromyalgia in Older Individuals
Fibromyalgia (FM) is a condition of chronic widespread pain (CWP) that can occur throughout the life cycle and is likely underrecognized in older...
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Early post-immobilization pain at rest, movement evoked pain, and their ratio as potential predictors of pain and disability at six- and 12-months after distal radius fracture
BackgroundRemoval of immobilization is a critical phase of distal radius fracture (DRF) rehabilitation, typically occurring by 2 months post injury....
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Tapering of prescribed opioids in patients with long-term non-malignant pain (TOPIO)—efficacy and effects on pain, pain cognitions, and quality of life: a study protocol for a randomized controlled clinical trial with a 12-month follow-up
BackgroundOpioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor...
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(Neuro)Inflammatory Component May Be a Common Factor in Chronic Widespread Pain and Restless Legs Syndrome
Purpose of ReviewRecent studies have linked fibromyalgia (nociplastic pain) and depression to neuroinflammation. Restless legs syndrome (RLS) is...
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Conservative Management of Occipital Neuralgia Supported by Physical Therapy: A Review of Available Research and Mechanistic Rationale to Guide Treatment
Purpose of ReviewConservative management is consistently recommended as a first line intervention for occipital neuralgia (ON); however, there is...
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Psychometric validation of the Polish version of the Central Sensitization Inventory in subjects with chronic spinal pain
BackgroundCentral sensitization is an amplification of neuronal signaling within the central nervous system. The Central Sensitization Inventory was...
