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Meta-regression of genome-wide association studies to estimate age-varying genetic effects
Fixed-effect meta-analysis has been used to summarize genetic effects on a phenotype across multiple Genome-Wide Association Studies (GWAS) assuming...
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Detecting failure modes in image reconstructions with interval neural network uncertainty
PurposeThe quantitative detection of failure modes is important for making deep neural networks reliable and usable at scale. We consider three...
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LASSO type penalized spline regression for binary data
BackgroundGeneralized linear mixed models (GLMMs), typically used for analyzing correlated data, can also be used for smoothing by considering the...
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Absorbed dose simulation of meta-211At-astato-benzylguanidine using pharmacokinetics of 131I-MIBG and a novel dose conversion method, RAP
ObjectiveWe aimed to estimate in vivo 211 At-labeled meta -benzylguanidine ( 211 At-MABG) absorbed doses by the two dose conversion methods, using 131 I-M...
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Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression
Identifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease...
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Evaluation of the prophylactic and therapeutic efficacies of mucus and tissue nucleoproteins extracted from Biomphalaria alexandrina snails on schistosomiasis mansoni
Schistosomiasis is a neglected tropical disease with considerable morbidity. The lone effective drug, praziquantel (PZQ), is showing emergence of...
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Dementia death rates prediction
BackgroundPrevalence of dementia illness, causing certain morbidity and mortality globally, places burden on global public health. This study primary...
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How to perform prespecified subgroup analyses when using propensity score methods in the case of imbalanced subgroups
BackgroundLooking for treatment-by-subset interaction on a right-censored outcome based on observational data using propensity-score (PS) modeling is...
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Triglyceride-glucose index, renal function and cardiovascular disease: a national cohort study
BackgroundThe triglyceride-glucose (TyG) index is a predictor of cardiovascular diseases; however, to what extent the TyG index is associated with...
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Ascertaining asthma status in epidemiologic studies: a comparison between administrative health data and self-report
BackgroundStudies have suggested that agreement between administrative health data and self-report for asthma status ranges from fair to good, but...
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Economic Evaluations Comparing Deep Brain Stimulation to Best Medical Therapy for Movement Disorders: A Meta-Analysis
BackgroundMovement disorders (Parkinson’s disease, essential tremor, primary dystonia) are a debilitating group of conditions that are progressive in...
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Planning a method for covariate adjustment in individually randomised trials: a practical guide
BackgroundIt has long been advised to account for baseline covariates in the analysis of confirmatory randomised trials, with the main statistical...
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Disease progression model anchored around clinical diagnosis in longitudinal cohorts: example of Alzheimer’s disease and related dementia
BackgroundAlzheimer’s disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including...
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Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting
The aberration in cortical gyrification seen in schizophrenia likely originates in the earliest phase of life, as gyrification begins in utero and...
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Modeling Cash Plus Other Psychosocial and Structural Interventions to Prevent HIV Among Adolescent Girls and Young Women in South Africa (HPTN 068)
Poverty alleviation programs can reduce HIV incidence but may have greater impacts when combined with other psychosocial interventions. We modeled...
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Estimating sensitivity and specificity of diagnostic tests using latent class models that account for conditional dependence between tests: a simulation study
BackgroundLatent class models are increasingly used to estimate the sensitivity and specificity of diagnostic tests in the absence of a gold...
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Quasi-rerandomization for observational studies
BackgroundIn the causal analysis of observational studies, covariates should be carefully balanced to approximate a randomized experiment. Numerous...
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Model selection for component network meta-analysis in connected and disconnected networks: a simulation study
BackgroundNetwork meta-analysis (NMA) allows estimating and ranking the effects of several interventions for a clinical condition. Component network...
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High-dimensional mediation analysis for continuous outcome with confounders using overlap weighting method in observational epigenetic study
BackgroundMediation analysis is a powerful tool to identify factors mediating the causal pathway of exposure to health outcomes. Mediation analysis...
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Safety and Effectiveness of Direct Oral Anticoagulants Versus Warfarin for Treating Left Ventricular Thrombus
BackgroundPatients with left ventricular thrombus are at high risk for ischemic stroke and systemic embolization. The mainstay of treatment is...
