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MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma
Tubo-ovarian high-grade serous carcinomas (HGSC) are highly proliferative neoplasms that generally respond well to platinum/taxane chemotherapy. We...
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Exploring a multiparameter MRI–based radiomics approach to predict tumor proliferation status of serous ovarian carcinoma
ObjectivesTo develop a multiparameter magnetic resonance imaging (MRI)-based radiomics approach that can accurately predict the tumor cell...
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Ovarian cancer management in an ESGO ovarian cancer center of excellence: a systematic case study of the interprofessional and interdisciplinary interaction
PurposeWith growing knowledge about ovarian cancer over the last decades, diagnosis, evaluation and treatment of ovarian cancer patients have become...
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Wip1 suppresses angiogenesis through the STAT3-VEGF signalling pathway in serous ovarian cancer
Multifaceted functions of the so-called “oncogene” Wip1 have been reported in a previous study, while its actual role remains to be explored in...
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Deep learning-based segmentation of multisite disease in ovarian cancer
PurposeTo determine if pelvic/ovarian and omental lesions of ovarian cancer can be reliably segmented on computed tomography (CT) using fully...
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Low Grade Serous Ovarian Cancer: Is disturbed Receptor Ratio (ER: PgR) an Etiogenic Factor?
IntroductionSerous ovarian carcinomas (SOCs) are the commonest epithelial ovarian carcinomas (EOCs). EOCs are subdivided into low-grade serous...
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C/EBPβ promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer
PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However,...
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Rare Case of Metachronous Gastric Metastasis from Primary Ovarian Carcinoma
Metastasis of ovarian cancer to the stomach is extremely rare. The tumors most commonly metastasizing to the stomach include melanoma, breast, lung,...
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High-throughput approaches for precision medicine in high-grade serous ovarian cancer
High-grade serous carcinoma (HGSC) is the most prevalent and aggressive subtype of ovarian cancer. The large degree of clinical heterogeneity within...
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Immune microenvironment composition in high-grade serous ovarian cancers based on BRCA mutational status
PurposeAn in-depth analysis of the tumor microenvironment of ovarian cancer is needed. The purpose of this study was to elucidate the architecture of...
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SPON1 is an independent prognostic biomarker for ovarian cancer
BackgroundOvarian cancer has the worst outcome among gynecological malignancies; therefore, biomarkers that could contribute to the early diagnosis...
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Histologic Subtypes in Endometriosis-Associated Ovarian Cancer and Ovarian Cancer Arising in Endometriosis: A Systematic Review and Meta-Analysis
The definition of the association between ovarian cancer and endometriosis was first reported by Sampson in 1925. He identified the following...
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Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer
BackgroundHigh-grade serous ovarian cancer (HGSOC) is the most common and lethal subtype of ovarian cancer. A growing body of evidence suggests...
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Molecular predictors of the outcome of paclitaxel plus carboplatin neoadjuvant therapy in high-grade serous ovarian cancer patients
BackgroundPatients with advanced high-grade serous ovarian cancer (HGSOC) are usually treated with paclitaxel and carboplatin; however, predictive...
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Functional analysis and validation of oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing
BackgroundHigh-grade serous ovarian carcinoma (HGSOC) is the most aggressive and prevalent subtype of ovarian cancer and accounts for a significant...
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Programmed death ligand-1 and CD8 tumor-infiltrating lymphocytes (TILs) as prognostic predictors in ovarian high-grade serous carcinoma (HGSC)
BackgroundP D-L1 is expressed in tumor cells and plays a crucial role in tumor immune escape. Tumor-infiltrating lymphocytes (TILs) as CD8 T cells...
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Low-grade serous epithelial ovarian cancer: a comprehensive review and update for radiologists
Low-grade serous carcinoma (LGSC) is an infrequent subtype of ovarian cancer, corresponding to 5% of epithelial neoplasms. This subtype of ovarian...
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Molecular characterization of low-grade serous ovarian carcinoma identifies genomic aberrations according to hormone receptor expression
Hormone receptor expression is a characteristic of low-grade serous ovarian carcinoma (LGSOC). Studies investigating estrogen receptor (ER) and...
