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Corneal densitometry in Chinese adults with healthy corneas: associations with sex, age, ocular metrics, and optical characteristics
BackgroundStandardized corneal densitometry (CD) values in large samples of healthy Chinese individuals are scarce. Therefore, we aimed to determine...
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Calf circumference predicts frailty in older adults: the Chinese longitudinal healthy longevity survey
BackgroundAlthough frailty is a common geriatric syndrome in old adults, a simple method to assess the degree of frailty in a person has not yet been...
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Cone-driven strong flash electroretinograms in healthy adults: Prevalence of negative waveforms
PurposeBoth rod and cone-driven signals contribute to the electroretinogram (ERG) elicited by a standard strong flash in the dark. Negative ERGs...
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Safety, tolerability, pharmacokinetics, and immunogenicity of JMB2002–an antibody against COVID-19: a phase 1 clinical trial in healthy Chinese adults
BackgroundThe emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and subsequent Coronavirus Disease 2019 (COVID-19) pandemic...
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Implementing multicomponent, eHealth-based behaviour change support within a dietary intervention trial improves adherence to study-related behaviours in healthy young adults
BackgroundBehaviour change science is proposed to improve participant retention and enhance the validity of trials. However, researchers seldom...
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Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry
BackgroundDuring biological aging, significant metabolic dysregulation in the central nervous system may lead to cognitive decline and...
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Safety, Tolerability and Pharmacokinetics of Icapamespib, a Selective Epichaperome Inhibitor, in Healthy Adults
BackgroundNeurodegenerative diseases are devastating conditions that most commonly affect individuals 65 years and older. Currently there are no...
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Comparison of resistance training vs static stretching on flexibility and maximal strength in healthy physically active adults, a randomized controlled trial
BackgroundThe aim of the present study was to compare the effects of resistance training through full range of motion and static stretching (SS) of...
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Associations of serum 25-hydroxyvitamin D with serum folate, cobalanin, and homocysteine concentrations and methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in healthy adults
AimThe aim of this study was to investigate the associations of serum 25-hydroxyvitamin D [25(OH)D] with various demographic, anthropometric, and...
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Cross-platform comparison of precision and time effectiveness of automated versus semi-automated brain volumetric measurements in healthy Egyptian adults
BackgroundThe primary goal of this study is to evaluate the precision, time effectiveness and reproducibility of open source automated magnetic...
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Roles of Baseline Intrinsic Capacity and its Subdomains on the Overall Efficacy of Multidomain Intervention in Promoting Healthy Aging among Community-Dwelling Older Adults: Analysis from a Nationwide Cluster-Randomized Controlled Trial
BackgroundImpaired intrinsic capacity (IC), which affects approximately 90% of older adults, is associated with a significantly heightened risk of...
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Impact of Varying Transcutaneous Electrical Stimulation Pulse Frequency on Swallow Timing Measures in Healthy Adults
The impaired swallow timing subsequent to dysphagia or aging can potentially endanger swallowing safety and efficiency. Preliminary evidence has...
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Anterior cruciate ligament femoral footprint is oblong-ovate, triangular, or two-tears shaped in healthy young adults: three-dimensional MRI analysis
PurposeThis study aimed to evaluate the morphology of the anterior cruciate ligament (ACL) femoral footprint with three-dimensional magnetic...
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Relative Bioavailability Study of Midazolam Intramuscularly Administered with the Needle-Free Auto-Injector ZENEO® in Healthy Adults
IntroductionIntramuscular (IM) midazolam is indicated for the treatment of status epilepticus. Administration must be efficient to rapidly terminate...
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US Adults’ Likelihood to Participate in Dementia Prevention Drug Trials: Results from the National Poll on Healthy Aging
BackgroundRecruitment to dementia prevention clinical trials is challenging, and participants are not representative of US adults at risk. A better...
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Comparison of low-dose maximal-intent versus controlled-tempo resistance training on quality-of-life, functional capacity, and strength in untrained healthy adults: a comparative effectiveness study
Lack of physical activity is a global issue for adults that can lead to sedentary behaviour and a higher prevalence of health complications and...
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Psychometric properties of a standardized protocol of muscle strength assessment by hand-held dynamometry in healthy adults: a reliability study
BackgroundMaximal isometric muscle strength (MIMS) assessment is a key component of physiotherapists’ work. Hand-held dynamometry (HHD) is a simple...
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Transitioning from having no metabolic abnormality nor obesity to metabolic impairment in a cohort of apparently healthy adults
IntroductionThe global prevalence of metabolic syndrome and its association with increased morbidity and mortality has been rigorously studied....
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Sedentary behavior is associated with reduced cardiovagal baroreflex sensitivity in healthy adults
Sedentary behavior is an established risk factor for cardiovascular disease; however, it remains unclear whether sedentary behavior is associated...
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The relationship between low-carbohydrate diet score, dietary insulin index and load with obesity in healthy adults
PurposeCarbohydrate intake and insulinemic potential of diet are suggested to be correlated with the development of different chronic diseases....