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Pathogenic Mechanisms in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is the most common form of leukemia in adults, leading to the highest number of annual leukemia-associated deaths in the...
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Menin is necessary for long term maintenance of meningioma-1 driven leukemia
Translocations of Meningioma-1 (MN1) occur in a subset of acute myeloid leukemias (AML) and result in high expression of MN1, either as a full-length...
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Phase separations in oncogenesis, tumor progressions and metastasis: a glance from hallmarks of cancer
Liquid–liquid phase separation (LLPS) is a novel principle for interpreting precise spatiotemporal coordination in living cells through biomolecular...
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Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns
BackgroundThe receptor tyrosine kinase FLT3 with internal tandem duplications within the juxtamembrane domain ( FLT3 -ITD) is a poor prognostic...
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Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins
Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It...
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ASXL1 mutations with serum EPO levels predict poor response to darbepoetin alfa in lower-risk MDS: W-JHS MDS01 trial
Darbepoetin alfa (DA) is used to treat anemia in lower-risk (IPSS low or int-1) myelodysplastic syndromes (MDS). However, whether mutations can...
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Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target
Progression of chronic lymphocytic leukemia (CLL) results from the expansion of a small fraction of proliferating leukemic B cells. When comparing...
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Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis
The Switch/Sugar Non-Fermenting (SWI/SNF) nucleosome remodeling complexes play important roles in normal development and in the development of...
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The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2V617F mutated cells
The transcription factor NFE2 is overexpressed in most patients with myeloproliferative neoplasms (MPN). Moreover, mutations in NFE2, found in a...
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Biomarkers of disease recurrence in stage I testicular germ cell tumours
Stage I testicular cancer is a disease restricted to the testicle. After orchiectomy, patients are considered to be without disease; however, the...
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Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis
ObjectiveAcute myeloid leukemia (AML) is an aggressive hematological malignancy characterized by abnormal myeloid blast expansion. Recent studies...
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Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML
Acute myeloid leukemia (AML) is driven by mutations that occur in numerous combinations. A better understanding of how mutations interact with one...
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Targeting RNA-binding proteins in acute and chronic leukemia
RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP...
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Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias
Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated...
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A primary hierarchically organized patient-derived model enables in depth interrogation of stemness driven by the coding and non-coding genome
Many cancers are organized as cellular hierarchies sustained by cancer stem cells (CSC), whose eradication is crucial for achieving long-term...
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Aberrant Expression of IncRNA (HOXAII-ASI) and Homeobox A (HOXA9, HOXA10, HOXA11, and HOXA13) Genes in Infertile Women with Endometriosis
This study aimed to study the expression of homeobox (HOX)A11-ASI ( HOXA11 antisense RNA) long noncoding RNA (IncRNA) and the expression of homeobox A...
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Targeting PARP proteins in acute leukemia: DNA damage response inhibition and therapeutic strategies
The members of the Poly(ADP‐ribose) polymerase (PARP) superfamily are involved in several biological processes and, in particular, in the DNA damage...
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Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia
ObjectiveTo describe the features of ETV6::ABL1 AML as well as the clinical treatment and outcomes.
MethodsClinical data were collected from three...
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microRNA signatures associated with fetal growth restriction: a systematic review
Placental-origin microRNA (miRNA) profiles can be useful toward early diagnosis and management of fetal growth restriction (FGR) and associated...
