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The power of three-dimensional printing technology in functional restoration of rare maxillomandibular deformity due to genetic disorder: a case report
BackgroundThalassemia is an inherited autosomal recessive blood disorder causing abnormal formation of hemoglobin, known as a syndrome of anemia with...
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Cardiorenal syndrome in thalassemia patients
BackgroundCardiorenal syndrome (CRS), a serious condition with high morbidity and mortality, is characterized by the coexistence of cardiac...
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Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice
Iron overload (IOL) is hypothesized to contribute to dysplastic erythropoiesis. Several conditions, including myelodysplastic syndrome, thalassemia...
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Recent advances in hematopoietic cell transplantation for inherited bone marrow failure syndromes
Inherited bone marrow failure syndromes (IBMFSs) are a group of rare genetic disorders characterized by bone marrow failure with unique phenotypes...
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Inhibition of ERK1/2 signaling prevents bone marrow fibrosis by reducing osteopontin plasma levels in a myelofibrosis mouse model
Clonal myeloproliferation and development of bone marrow (BM) fibrosis are the major pathogenetic events in myelofibrosis (MF). The identification of...
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Stable colony-stimulating factor 1 fusion protein treatment increases hematopoietic stem cell pool and enhances their mobilisation in mice
BackgroundPrior chemotherapy and/or underlying morbidity commonly leads to poor mobilisation of hematopoietic stem cells (HSC) for transplantation in...
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Contributions of bone marrow monocytes/macrophages in myeloproliferative neoplasms with JAK2V617F mutation
The classic BCR-ABL1-negative myeloproliferative neoplasm (MPN) is a highly heterogeneous hematologic tumor that includes three subtypes, namely...
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Macrophage depletion using clodronate liposomes reveals latent dysfunction of the hematopoietic microenvironment associated with persistently imbalanced M1/M2 macrophage polarization in a mouse model of hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH), a hyperinflammatory syndrome, is caused by the incessant activation of lymphocytes and macrophages,...
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Hemangioblastoma with late leptomeningeal metastasis: a case report
BackgroundHemangioblastoma of the central nervous system is an uncommon benign neoplasm, with about 25% of cases in patients with von Hippel–Lindau...
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Management and outcome of patients with chronic myeloid leukemia in blast phase in the tyrosine kinase inhibitor era – analysis of the European LeukemiaNet Blast Phase Registry
Blast phase (BP) of chronic myeloid leukemia (CML) still represents an unmet clinical need with a dismal prognosis. Due to the rarity of the...
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A case of congenital capillary proliferation of the kidney (CCPK)
We report a case of congenital capillary proliferation of the kidney (CCPK) along with the multimodality imaging findings. Four-day-old boy who had...
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Postmortem findings in Magellanic penguins (Spheniscus magellanicus) caught in a drift gillnet
BackgroundPenguin interaction with gillnets has been extensively reported in the Atlantic and Pacific Oceans, and is considered a major conservation...
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Läsionen des paravertebralen Mediastinums
BackgroundLesions of the paravertebral mediastinum are rare, and knowledge of possible differential diagnoses is essential for clinical practice.
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Graft-versus-host disease and impact on relapse in myelofibrosis undergoing hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only curative treatment for myelofibrosis (MF). Relapse occurs in 10–30%...
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Unusual Presentation of Concurrent Cutaneous Plasmablastic Lymphoma and Acute Myeloid Leukemia: a Case Report and a Comprehensive Review
Plasmablastic lymphoma (PBL) is a rare type of non-Hodgkin’s lymphoma, primarily seen in patients with immunosuppression, particularly HIV. It...
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Exome sequencing analysis of gastric primary myeloid sarcoma with monocytic differentiation with altered immunophenotype after chemotherapy: case report
BackgroundMyeloid Sarcoma with monocytic differentiation is rare and quite likely is missed by surgical pathologists. However it is frequently...
