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Cellular and Molecular Mechanisms of Mast Cells in Atherosclerotic Plaque Progression and Destabilization
Mast cells (MCs) are commonly recognized for their crucial involvement in the pathogenesis of allergic diseases, but over time, it has come to light...
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HDL functionality in type 1 diabetes: enhancement of cholesterol efflux capacity in relationship with decreased HDL carbamylation after improvement of glycemic control
BackgroundReduced cholesterol efflux capacity (CEC) of HDLs is likely to increase cardiovascular risk in type 1 diabetes (T1D). We aimed to assess...
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mRNA-based therapeutics: powerful and versatile tools to combat diseases
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide range of incurable diseases. Recent rapid advances in...
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Optimizing Dyslipidemia Management for the Prevention of Cardiovascular Disease: a Focus on Risk Assessment and Therapeutic Options
AbstractPrimary prevention of incident atherosclerotic cardiovascular disease (ASCVD) as well as decreasing the risk of future events in those with...
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Hepatic expression of cholesterol regulating genes favour increased circulating low-density lipoprotein in HIV infected patients with gallstone disease: a preliminary study
BackgroundHIV endemic populations are displaying higher incidence of metabolic disorders. HIV and the standard treatment are both associated with...
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The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk
Purpose of ReviewNonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are strongly associated. Both also associate with an...
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Alzheimer’s Disease: Novel Targets and Investigational Drugs for Disease Modification
Novel agents addressing non-amyloid, non-tau targets in Alzheimer’s Disease (AD) comprise 70% of the AD drug development pipeline of agents currently...
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Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in lipid metabolism and a revolutionary therapeutic target for...
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High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank
ObjectiveHigh-density lipoproteins (HDL) comprise particles of different size, density and composition and their vasoprotective functions may differ....
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New Drug Delivery Systems Developed for Brain Targeting
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (B CSF ) are two of the most complex and sophisticated concierges that defend...
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Nucleic acid drug vectors for diagnosis and treatment of brain diseases
Nucleic acid drugs have the advantages of rich target selection, simple in design, good and enduring effect. They have been demonstrated to have...
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RSSDI consensus recommendations for dyslipidemia management in diabetes mellitus
Diabetic dyslipidemia is characterised by low HDL-C and high triglyceride levels. Unlike the Caucasian population, though LDL-C levels are not very...
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Non-linear relationship between high-density lipoprotein cholesterol and incident diabetes mellitus: a secondary retrospective analysis based on a Japanese cohort study
Background and objectiveHigh-density lipoprotein cholesterol (HDL-C) may be directly involved in glucose metabolism by enhancing insulin sensitivity...
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Effect of thyroid function on pre-β1 high-density lipoprotein levels in patients with Graves’ disease undergoing radioiodine treatment
ContextThe metabolism of HDL is altered in thyroid dysfunctions. Preβ-1 HDL is a very small discoidal precursor HDL and promotes cholesterol efflux...
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Small molecules in the treatment of COVID-19
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies and economies. Until now, effective therapeutics...
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Relationship between lipoprotein concentrations and short-term and 1-year mortality in intensive care unit septic patients: results from the HIGHSEPS study
BackgroundHigh-density lipoproteins (HDLs), particles characterized by their reverse cholesterol transport function, display pleiotropic properties,...
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Novel treatments for congenital adrenal hyperplasia
Patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) need life-long medical treatment to replace the lacking...
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Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined...
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Current Approach to the Diagnosis and Treatment of Heterozygote and Homozygous FH Children and Adolescents
Purpose of ReviewTo elucidate the current approach of care in pediatric patients with familial hypercholesterolemia (FH). We sought an answer to the...
